Impact of coronavirus disease 2019 pandemic-related community quarantine on overall and cause-specific mortality in Jiangsu Province, China

Yu, Hao; Luo, Pengfei; Tao, Ran; Han, Renqiang; Zhou, Jinyi; Wu, Ming

doi:10.2471/blt.20.269381

Cited by 1 publication

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“…The incidence rate of cervical cancer in developing countries is about 10 times that in developed countries. In China, the incidence rate of cervical cancer ranks first among those of all gynecological malignancies 5 , and the mortality rate of cervical cancer in rural areas is 48% higher than that in urban areas 6 . In clinical practice, cervical cancer is mainly treated by surgery, radiotherapy, chemotherapy and their combination.…”

Section: Discussionmentioning

confidence: 99%

Expression of miR-152 in cervical cancer and its influence on cisplatin resistance

Wu,

Chi,

Yang

et al. 2023

Afr H. Sci.

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Background: Cervical cancer has a high mortality rate. Aim: We aimed to study the expression of micro ribonucleic acid 152 (miR-152) in cervical cancer and its influence on cisplatin(DDP) resistance. Methodology: Cervical cancer Hela cells were divided into control, DDP, DDP + mimic nc and DDP + miR-152 mimic groups. Results: DDP, DDP + mimic nc and DDP + miR-152 mimic groups had lower cell survival rate, smaller number of single clones and cells penetrating the membrane, and higher apoptosis rate and miR-152 expression than those of the control group (P<0.05). Compared with DDP and DDP + mimic nc groups, the cell survival rate, number of single clones and number of cells penetrating the membrane significantly decreased, while the apoptosis rate and miR-152 expression increased in the DDP + miR-152 mimic group (P<0.05). ERBB3 was a downstream target gene of miR-152. Hela cells transfected with miR-152 mimic had lower protein expressions of Snail, ERBB3, Akt2, p-Akt and c-myc than those of NC cells (P<0.05). Conclusion: MiR-152 suppresses the proliferation, migration and infiltration of cervical cancer cells and reduces their resistanceto DDP chemotherapy by inhibiting the expressions of proteins in the ERBB3/Akt/c-myc and ERBB3/Akt/Snail pathways. Keywords: miR-152; cervical cancer; cisplatin; drug resistance.

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Section: Discussionmentioning

confidence: 99%

Expression of miR-152 in cervical cancer and its influence on cisplatin resistance

Wu,

Chi,

Yang

et al. 2023

Afr H. Sci.

View full text Add to dashboard Cite

show abstract

Impact of coronavirus disease 2019 pandemic-related community quarantine on overall and cause-specific mortality in Jiangsu Province, China

Abstract: DISCLAIMER This paper was submitted to the Bulletin of the World Health Organization and was posted to the COVID-19 open site, according to the protocol for public health emergencies for international concern as described in Vasee Moorthy et al.

Cited by 1 publication

References 20 publications

Expression of miR-152 in cervical cancer and its influence on cisplatin resistance

Expression of miR-152 in cervical cancer and its influence on cisplatin resistance

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