There is no doubt that the coronavirus disease 2019 pandemic has changed the world in unprecedented ways. Among its turbulent effects, it has impacted many aspects of the lives of individuals, ranging from their mental health to finances. As such, it is essential to determine the psychosocial factors at play and examine how they have impacted the lives of people around the world. This chapter examines psychosocial factors, such as depression, anxiety, and stress, which have been on the rise. Furthermore, the interplay of mental health factors and other stressors brought on by the pandemic has led to the concern that cases of suicidal ideation are also increasing. In response to the stay-at-home orders, family members spent unprecedented amounts of time in close contact with one another, which has had mental health repercussions. In addition, changes in the format of lesson delivery have been stress-inducing and have robbed many students of proper education. Another factor is unemployment, which has been on the rise since the start of the pandemic. Finally, rates of sexual and domestic violence have also increased, significantly impacting women. Exercise, limiting media exposure, counseling, and maintaining social networks are the strategies that have been identified to mitigate the effects of the psychosocial factors discussed in this chapter.