The education sector in Pakistan has been the adversely hit because of the COVID-19 pandemic. The ensuing situation brought with it numerous challenges for academia, teachers, and students coupled with unique opportunities for stakeholders involved in the teaching-learning process. This chapter captures the impact of COVID-19 on higher education in Pakistan with special reference to the policy framework for online education at HEIs provided by the federal regulatory body (i.e., higher education commission) and its implementation at a large-scale, public, professional university in Karachi as a case. Using the case-based method, empirical evidence about the policy adoption, pedagogical design, and implementation with monitoring and evaluation are presented along with all three main stakeholders' (management, teachers, and learners) perspectives and experiences.