Impact of COVID-19 control measures on Legionella pneumophila infections in children in Henan, China

Zhou, Yang; Yan, Hui; Zhang, Qiang; Feng, Ruoqiang; Zhai, Bo

doi:10.1016/j.jinf.2023.04.020

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…All of these are known to be opportunities pathogens. Of these, L. pneumophila is a major causative agent of severe pneumonia (lung infection) and community-acquired pneumonia (CAP) and has also been reported to cause the co-infection with COVID-19 and can be potentially fatal [ 43 , 44 ]. Streptomyces and P. caribensis are associated with pathogenic agents in multiple respiratory infections [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…This difference in abundance was also reflected in the unclassified portion of samples when they were later characterized using POSMM. Conversely, we identified an overabundance of certain opportunistic pathogens, including L. pneumophila , Streptomyces , and P. distasonis , in COVID-19 patients, implicating them in disease pathogenesis [ 34 , 43 , 44 , 45 ]. The observed dysregulation of microbial communities, particularly in the gut, aligns with prior studies linking alterations in the microbiome to inflammatory conditions and immune dysfunction, thus providing valuable insights into the pathophysiology of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

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Deciphering Microbial Shifts in the Gut and Lung Microbiomes of COVID-19 Patients

Pusadkar,

Mazumder,

Azad

et al. 2024

Microorganisms

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COVID-19, caused by SARS-CoV-2, results in respiratory and cardiopulmonary infections. There is an urgent need to understand not just the pathogenic mechanisms of this disease but also its impact on the physiology of different organs and microbiomes. Multiple studies have reported the effects of COVID-19 on the gastrointestinal microbiota, such as promoting dysbiosis (imbalances in the microbiome) following the disease’s progression. Deconstructing the dynamic changes in microbiome composition that are specifically correlated with COVID-19 patients remains a challenge. Motivated by this problem, we implemented a biomarker discovery pipeline to identify candidate microbes specific to COVID-19. This involved a meta-analysis of large-scale COVID-19 metagenomic data to decipher the impact of COVID-19 on the human gut and respiratory microbiomes. Metagenomic studies of the gut and respiratory microbiomes of COVID-19 patients and of microbiomes from other respiratory diseases with symptoms similar to or overlapping with COVID-19 revealed 1169 and 131 differentially abundant microbes in the human gut and respiratory microbiomes, respectively, that uniquely associate with COVID-19. Furthermore, by utilizing machine learning models (LASSO and XGBoost), we demonstrated the power of microbial features in separating COVID-19 samples from metagenomic samples representing other respiratory diseases and controls (healthy individuals), achieving an overall accuracy of over 80%. Overall, our study provides insights into the microbiome shifts occurring in COVID-19 patients, shining a new light on the compositional changes.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Deciphering Microbial Shifts in the Gut and Lung Microbiomes of COVID-19 Patients

Pusadkar,

Mazumder,

Azad

et al. 2024

Microorganisms

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show abstract

“…A group of researchers from China found a decrease in childhood Legionella infections in Henan province during and after the COVID-19 pandemic, from January 2020 to October 2022. 27 This led to a counterargument about the effect of the COVID-19 pandemic on LD. The decrease in cases could be attributed to limited access to public places equipped with air conditioning, reduced exposure to the external environment with sewage, blockage of aerosols in household pipes, and the widespread use of masks.…”

Section: Legionnaires' Diseasementioning

confidence: 99%

Section: Clinical Impact Of Covid-19 On Legionnaires’ Diseasementioning

confidence: 99%

Resurgence of Legionella: A Post-COVID-19 Concern

Das,

Chaudhry

2024

ACS EST Water

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The COVID-19 pandemic has dealt a heavy blow to every continent globally. Most fatalities during the pandemic were due to subsequent bacterial infections; however, Legionella and SARS-CoV-2 co-infections were relatively rare yet significant. COVID-19 pandemic countermeasures (e.g., social distancing, mask wearing, etc.) appeared to be effective at reducing the occurrence of infections that were transmitted from person to person (e.g., pneumococcal disease). Conversely, these nonpharmaceutical interventions might marginally impact environmentally transmitted pathogens, such as Legionella pneumophila. In addition, it is suggested that COVID-19-associated stagnation may increase the incidence of legionellosis. Herein, we addressed the significant concern of whether Legionella is making a post-COVID-19 comeback. Few post-COVID Legionella studies collectively indicate a spike in Legionella activity associated with extended water stagnations due to the COVID-19 lockdown. In addition, surveillance data from a few countries (e.g., European Union countries) depicted a significant upward trend in the incidence of legionellosis especially after the pandemic restrictions had been eased. In the future, well-planned environmental surveys and global disease surveillance are required to monitor this respiratory pathogen in the post-COVID-19 landscape. Facility managers may develop robust water management programs and continue to adhere to them to detect and remediate Legionella within building water systems.

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Research Progress on the Epidemiological Trend of Pathogenic Spectrum of Community-Acquired Pneumonia in Children

赵

2024

JCPM

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Impact of COVID-19 control measures on Legionella pneumophila infections in children in Henan, China

Cited by 3 publications

References 9 publications

Deciphering Microbial Shifts in the Gut and Lung Microbiomes of COVID-19 Patients

Deciphering Microbial Shifts in the Gut and Lung Microbiomes of COVID-19 Patients

Resurgence of Legionella: A Post-COVID-19 Concern

Research Progress on the Epidemiological Trend of Pathogenic Spectrum of Community-Acquired Pneumonia in Children

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