Impact of COVID-19 in Children with Chronic Lung Diseases

Ferraro, Valentina; Zanconato, Stefania; Carraro, Silvia

doi:10.3390/ijerph191811483

Cited by 5 publications

(6 citation statements)

References 51 publications

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“…In the current study, the spirometry values at the third and sixth months after COVID-19 infection were similar to those measured before the infection and could be due to the patients having had a mild infection. Although COVID-19 infection has a mild course in children, 20 21 patients with ongoing respiratory symptoms after the infection should be followed up with respiratory function tests.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of the Risk Factors and Respiratory Function Test Change of Children with Cystic Fibrosis Who Contracted COVID-19 Infection

Özaslan

Şenol

Barlık

et al. 2023

J Pediatr Infect Dis

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Objective Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a global pandemic in March 2020, with millions of infected cases worldwide. Although the course is usually mild in the pediatric age group, there are unknown factors in patients with chronic lung diseases. The aim of this study was to determine the demographic characteristics and the clinical course of patients with cystic fibrosis who contracted COVID-19 infection. Methods A total of 128 patients with cystic fibrosis who were under follow-up in our clinic were separated into two groups: those who had been infected with COVID-19 and those who had not. The COVID-19-positive patients were then grouped as those who were hospitalized and those treated as outpatients. In the COVID-19 group, the spirometry values of the patients before the infection were compared with those measured at 3 and 6 months after the infection. Results The COVID-19 group comprised 34 (25.6%) cystic fibrosis patients with a mean age of 108.2 ± 60.8 months who contracted COVID-19 between April 2020 and October 2022. The rates of chronic bacterial colonization and allergic bronchopulmonary aspergillosis were significantly higher in the COVID-19 group (p = 0.001 and 0.005). Eight of the 34 patients were hospitalized, and 26 were isolated at home. Five patients required oxygen, and the forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) values were lower. Conclusion A severe course of COVID-19 was not seen in any of the cystic fibrosis patients. A greater number of patients with chronic respiratory tract bacterial colonization and allergic bronchopulmonary aspergillosis were hospitalized.

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Section: Discussionmentioning

confidence: 99%

An Evaluation of the Risk Factors and Respiratory Function Test Change of Children with Cystic Fibrosis Who Contracted COVID-19 Infection

Özaslan

Şenol

Barlık

et al. 2023

J Pediatr Infect Dis

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“…[12][13][14] Ferraro et al published a 2022 scoping review that mainly looked at the effect of healthcare delivery on children's disease status. 15 Hence, we aimed to conduct a systematic review and meta-analyses to determine the prevalence of SARS-CoV-2 infection, factors affected by severe COVID-19, and associated complications of COVID-19 in children with CLD.…”

Section: Coronavirus Disease 2019 (Covid-19mentioning

confidence: 99%

“…They found that 3.4% of the pediatric population had COVID-19 infection, with only one child requiring hospitalization. 15…”

Section: Completeness Of Evidencementioning

confidence: 99%

“…A recent scoping review found one study, in early 2021, which included 640 patients with PCD. They found that 3.4% of the pediatric population had COVID‐19 infection, with only one child requiring hospitalization 15 …”

Section: Completeness Of Evidencementioning

confidence: 99%

“…Many reviews on COVID‐19 in children with asthma were published in the early waves of the pandemic before COVID‐19 infection peaked in the pediatric population and their findings were inconclusive 12–14 . Ferraro et al published a 2022 scoping review that mainly looked at the effect of healthcare delivery on children's disease status 15 . Hence, we aimed to conduct a systematic review and meta‐analyses to determine the prevalence of SARS‐CoV‐2 infection, factors affected by severe COVID‐19, and associated complications of COVID‐19 in children with CLD.…”

Section: Introductionmentioning

confidence: 99%

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The outcome of COVID‐19 in children with chronic lung disease: Systematic review and meta‐analyses

Sallih

Wee

Zaki

et al. 2023

Pediatric Pulmonology

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Background: Few studies have examined the impact of Coronavirus disease (COVID-19) infection on children with chronic lung disease (CLD).Objective: To perform a systematic review and meta-analysis to determine the prevalence, risk factors for contracting COVID-19, and complications of COVID-19, in children with CLD. Methods: This systematic review was based on articles published between January 1, 2020 and July 25, 2022. Children under 18 years old, with any CLD and infected with COVID-19 were included. Results: Ten articles involving children with asthma and four involving children with cystic fibrosis (CF) were included in the analyses. The prevalence of COVID-19 in children with asthma varied between 0.14% and 19.1%. The use of inhaled corticosteroids (ICS) was associated with reduced risk for COVID-19 (risk ratio [RR]: 0.60, 95% confidence interval [CI]: 0.40-0.90). Uncontrolled asthma, younger age, AND moderate-severe asthma were not significant risk factors for contracting COVID-19. Children with asthma had an increased risk for hospitalization (RR: 1.62, 95% CI: 1.07-2.45) but were not more likely to require assisted ventilation (RR: 0.51, 95% CI: 0.14-1.90). The risk of COVID-19 infection among children with CF was <1%. Posttransplant and cystic fibrosisrelated diabetes mellitus (CFRDM) patients were at an increased risk for hospitalization and intensive care treatment. Conclusion: Hospitalizations were higher in children with asthma with COVID-19 infection. However, using ICS reduced the risk of COVID-19 infection. As for CF, postlung transplantation and CFRDM were risk factors for severe disease.

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