Impact of COVID-19 on Acute Invasive Fungal Rhinosinusitis:  A Comparative Study

Ebeid, Kamal; Gamea, Mohamed; Allam, Abdallah El Sayed; Shehata, Emad M.

doi:10.21608/ejentas.2021.76357.1369

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…Chronic kidneys and liver diseases, multiple organ dysfunction syndrome are also significant risk factors for bacterial-fungal chronic rhinosinusitis development [43]. In our study, chronic hepatitis was detected in 1 case (9.1%), chronic glomerulonephritis -in 1 case (9.1%), chronic pyelonephritis -in 1 case (9.1%).…”

Section: Discussionsupporting

confidence: 47%

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Myroshnychenko

Kalashnyk-Vakulenko

Kapustnyk³

et al. 2022

Wiad Lek

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The aim is to identify the etiology, clinical and morphological features of rhinosinusitis in patients in post-COVID-19 period. Materials and methods: In the present study, it was carried out the analysis of 11 cases of rhinosinusitis, which developed after COVID-19 infection. The diagnosis of rhi¬nosinusitis was established on the basis of anamnesis, clinical and laboratory examination, specialized instrumental examination (rhinoendoscopy, X-ray, magnetic resonance imaging, spiral and 3D computed tomography). All patients underwent endoscopic sanitation of the nasal cavity, expansion of the maxillary anastomosis, maxillary sinusotomy, sanitation of the maxillary sinuses and removal of pathologically altered tissues. Microbiological examination of the swab from the nasal cavity was carried out in all patients. Histological and morphometric research methods were used during the morphological study of surgical material. The nonparametric Mann-Whitney U test was used to compare the means in the groups. Results: The conducted comprehensive study made it possible to identify chronic atrophic rhinosinusitis at the stage of exacerbation caused by associations of bacteria and fungi in patients in post-COVID-19 period. Among bacteria, the authors most often noted Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumonia, Streptococcus pneumonia and Enterococcus faecalis. Among fungi, there were Aspergillus, Candida, Mucor and Coccidioides. Fungal infection was characterized by invasion into the mucous membrane of the nose and paranasal sinuses. In patients in post-COVID-19 period the invasive bacterial-fungal chronic atrophic rhinosinusitis at the stage of exacerbation was predominantly bilateral, characterized by the involvement of several or all paranasal sinuses in the process. Patients with such pathology complained of periodic fever, headaches and malaise; nasal congestion and constant difficulty in nasal breathing; yellowish-greenish-reddish discharge from the nasal cavity, sometimes with a fetid odor; discomfort and pain in the area of paranasal sinuses; immobility of the eyeball, hyposmia or anosmia; reduction or complete loss of vision. Frequent risk factors for the development of invasive bacterial-fungal chronic atrophic rhinosinusitis at the stage of exacerbation in patients in post-COVID-19 period were the information about moderate or severe course of this infection in anamnesis; comorbidities (predominantly diabetes mellitus, hypertensive disease and ischemic heart disease). Conclusions: The study conducted by the authors made it possible to identify the etiological, clinical and morphological features, as well as risk factors of rhinosinusitis in patients in post-COVID-19 period. This information will contribute to a better understanding of such pathology by the doctors and improve the diagnostic and treatment process.

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Section: Discussionsupporting

confidence: 47%

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Myroshnychenko

Kalashnyk-Vakulenko

Kapustnyk³

et al. 2022

Wiad Lek

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“…Ebeid et al [ 58 ] reported a dramatic increase in the rate of incidence of AIFR in patients with recent COVID-19 infection in comparison with pre-COVID-19 pandemic numbers. For 6-month period between July and December 2020, Tanta university hospitals (Egypt) admitted 28 AIFR patients.…”

Section: Discussionmentioning

confidence: 99%

Rhino-orbito-cerebral mucormycosis during the COVID-19 third wave in 2021: an Egyptian preliminary report from a single tertiary hospital

et al. 2021

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“…The exact pathophysiological mechanisms of this co-infection are unknown. It has been suggested that the incidence of IFRS is higher in post-COVID-19 patients than in non-COVID-19 patients [3,4], notably, in immunocompetent patients. Research on SARS-CoV and SARS-CoV-2 showed remarkable similarities in their mechanisms, both increasing the incidence of fungal invasion.…”

Section: Discussionmentioning

confidence: 99%

Invasive Fungal Rhinosinusitis in the Era of COVID-19: Is It an Emerging Association?

Chatzisouleiman¹,

Lialiaris²,

Zisoglou³

et al. 2022

Cureus

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Invasive fungal rhinosinusitis (IFRS) typically affects immunocompromised patients. The coronavirus disease 2019 (COVID-19) pandemic may be associated with rare opportunistic fungal infections, probably as a result of immune dysregulation. The COVID-19 infection is characterized by low levels of CD4+T and CD8+T cells which could increase the risk of co-infections from Mucor or Aspergillus species. An invasive fungal infection should be suspected in patients who have recently recovered from COVID-19 pneumonia and present with acute destructive rhinosinusitis. There are few cases of IFRS reported in Europe during the pandemic of COVID-19. We describe the case of a 67-year-old patient with diabetes who received corticosteroids during the treatment for COVID-19 infection and was readmitted a few days later for radiologically and clinically suggested IFRS. Aspergillus niger was identified, and the patient received pharmacological and surgical treatment.

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Impact of COVID-19 on Acute Invasive Fungal Rhinosinusitis: A Comparative Study

Cited by 5 publications

References 10 publications

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Rhino-orbito-cerebral mucormycosis during the COVID-19 third wave in 2021: an Egyptian preliminary report from a single tertiary hospital

Invasive Fungal Rhinosinusitis in the Era of COVID-19: Is It an Emerging Association?

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