Impact of COVID-19 on disease progression and postoperative complications in patients with head and neck cancer

Nadarajan, Abinaya R.; George, Nebu Abraham; Thomas, Shaji; Varghese, Bipin T.; Iype, Elizabeth Mathew; Krishna, Jagathnath

doi:10.1016/j.ejso.2022.11.183

Cited by 2 publications

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“…Retrospective review using a large database found that patients positive within 7 days before or after surgery were at significantly higher risk for multiple medical and surgical complications in the perioperative period. While a recent observational study conducted at a single institution in South India showed similar results, this is the largest retrospective multi‐institutional study demonstrating increased risk of perioperative complication due to COVID‐19 infection to the author's best knowledge 5 …”

Section: Discussionsupporting

confidence: 61%

“…While a recent observational study conducted at a single institution in South India showed similar results, this is the largest retrospective multi-institutional study demonstrating increased risk of perioperative complication due to COVID-19 infection to the author's best knowledge. 5 COVID-19 complications and mortality have largely been associated with pulmonary and cardiovascular pathologies. Interestingly, the pulmonary complications associated with the COVID-19 infection deviate from the typical pathophysiology seen in acute respiratory distress syndrome (ARDS).…”

Section: Discussionmentioning

confidence: 99%

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Perioperative complications among head and neck surgery patients with COVID‐19

Martin,

Elliott,

Chisolm

et al. 2023

Head & Neck

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BackgroundPatients undergoing surgery for head and neck cancer (HNC) have potentially high perioperative complication rates. Recent studies indicate that preoperative COVID‐19 infection poses increased risk for postoperative complications in other fields. However, to date, there has not been data showing the effect of COVID‐19 on complication rates for HNC. Here, a large database was employed to assess if perioperative COVID‐19 increased the risk of perioperative complications among those undergoing HNC surgery.MethodsA retrospective investigation was conducted using a multi‐institutional research database. Subjects who underwent HNC surgery from January 2020 to September 2022 were identified using the International Classification of Diseases and Current Procedure Terminology codes. Thirty‐day surgical and medical complications were assessed for those diagnosed with COVID‐19 infection from 7 days before or after surgery compared to those who were COVID‐19 negative. Cohorts were propensity scores matched by age, sex, and race.ResultsPerioperative COVID‐19 was present in n = 208 and absent in n = 15 158 subjects that underwent HNC surgery. For unmatched analyses, there was a statistically significant increased risk in the 30‐day postoperative period in COVID‐19‐positive patients for the following surgical complications: surgical site fistula, free tissue transfer (FTT) complication, FTT failure, and death. Additionally, there was a statistically significant increased risk in the 30‐day postoperative period in COVID‐19‐positive patients for the following medical complications: ventilator support, pneumonia, vasopressor, acute renal failure, and myocardial infarction.ConclusionThis large, retrospective populational study suggests HNC patients are at increased risk for death and several perioperative complications. This investigation is the first to address this clinical question.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Perioperative complications among head and neck surgery patients with COVID‐19

Martin,

Elliott,

Chisolm

et al. 2023

Head & Neck

View full text Add to dashboard Cite

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“…In the head and neck region, there may be a risk of upper respiratory tract symptoms due to COVID-19 infection and associated deterioration of the general condition. In addition to the early reports of the COVID-19 pandemic [ 13 ], Koizumi et al [ 14 ] reported on the impact of the COVID-19 pandemic on the number of otolaryngological surgeries, and Nadarajan et al [ 15 ] reported on the association between surgical complications and COVID-19. Nevertheless, to the best of our knowledge, there are no reports documenting the influence of COVID-19 on managing head and neck malignancies in the inpatient setting (as per a PubMed title search employing the query “COVID-19 head and neck cancer hospitalization”).…”

Section: Introductionmentioning

confidence: 99%

Impact of the COVID-19 Infection on Head and Neck Cancer Treatment During Hospitalization

Kawaura,

Shibata,

Okuda

et al. 2024

Cureus

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Objective The after-effects of coronavirus disease 2019 (COVID-19) infection are still unknown; therefore, we investigate the possibility that COVID-19 may interrupt cancer treatment and impact prognosis. Methods We examined the characteristics, prognosis, and changes in treatment options before and after COVID-19 in 11 head and neck cancer patients who were infected with COVID-19 after admission for cancer treatment at Gifu University Hospital. These patients were compared to 110 patients unaffected by COVID-19 during the same period. To identify the effects of COVID-19 on the cancer treatment sequence, we examined the rates of overall survival, progression-free survival, and completion, as well as radiation dosage in radiotherapy and cisplatin dosage in chemoradiotherapy. Results All 11 patients with COVID-19 had their planned cancer treatment postponed or interrupted. There was no significant difference in overall or progression-free survival compared to patients without COVID-19. Notably, only 3/6 of the COVID-19-affected patients completed radiotherapy compared to 42/46 unaffected patients. The ratio of actual radiation dose to planned dose was significantly impaired in COVID-19 affected patients group (98.3% vs. 88.6%). Cisplatin dosage in chemoradiation was not significantly different in either the radical (100 mg/m 2 , every three weeks) or adjuvant (40 mg/m 2 , every one week) treatment groups. Conclusion COVID-19 infection in head and neck cancer patients had no apparent impact on cancer prognosis. However, when restricted to irradiation, the treatment completion rate and the ratio of planned to actual dose decreased significantly, underscoring the impact of COVID-19 infection on cancer treatment. The difference in irradiation may affect the success of patients’ treatment going forward, and it should be explored whether irradiation can be continued without delay.

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Impact of COVID-19 on disease progression and postoperative complications in patients with head and neck cancer

Cited by 2 publications

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Perioperative complications among head and neck surgery patients with COVID‐19

Perioperative complications among head and neck surgery patients with COVID‐19

Impact of the COVID-19 Infection on Head and Neck Cancer Treatment During Hospitalization

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