The current investigation examines the asymmetric influence of pandemic uncertainty on drug-related crimes in the top 10 countries with a highest prevalence of such offenses (Mexico, Colombia, Philippines, Brazil, USA, Venezuela, Peru, Nigeria, Russia, and South Africa). Previous research used panel data methods to explore this connection without considering the specific variations among different countries. Conversely, this study uses Quantile-on-Quantile approach by providing worldwide yet country-specific insights for every economy individually. The findings demonstrate that pandemic uncertainty decreases drug-related crimes in the Philippines, Venezuela, Peru, and Russia. Conversely, it showcases an increase in such crimes in Colombia, the USA, Nigeria, and South Africa. It is recommended to formulate effective strategies to address changes in pandemic uncertainty and drug-related crimes.