The impacts of COVID-19 have been felt globally, especially in the delivery of healthcare services such as dental care, although the incidence in Africa is comparatively low. This review article aims to explore the COVID-19 pandemic lockdown and its impact on dental care for children in Ghana. Some dental facilities in Ghana have been experiencing multiple challenges in service delivery, and the ongoing COVID-19 pandemic has aggravated the situation. The COVID-19 pandemic has interrupted all dental care in many parts of Ghana due to its impact on food insecurity, economic breakdown, depression, shortage of essential instrument supplies, inadequate health workers, and poor infection control practices, which present the main risks to dental care. Furthermore, the shutting of dental departments due to the COVID-19 lockdown has restricted the accessibility and utilization of dental services, especially for children. Hence, to avoid further and future pandemics and their impacts on dental care, there is a need to address the implications identified and prepare for the delivery of suitable dental healthcare in Ghana.