Impact of COVID-19 Pandemic on Psychophysical Stress in Patients with Adrenal Insufficiency: The CORTI-COVID Study

Martino, Marianna; Aboud, Nairus; Cola, Marco Fabio; Giancola, Giulia; Ciarloni, Alessandro; Salvio, Gianmaria; Arnaldi, Giorgio

doi:10.2139/ssrn.3668368

Cited by 4 publications

(9 citation statements)

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“…As a comparison, at the time of survey completion, the overall prevalence of COVID-19 infection in the United States was 7.9% and the positivity rate was 8.4% ( 2 ). Lower than national rate of COVID-19 infection was also reported by Martino et al, where the prevalence of COVID-19 in patients with AI was 0.8%, as compared to 2.5% in Italy at the time of that study ( 17 ). Previous studies reported a higher susceptibility to infections and a higher likelihood to be hospitalized due to infections in both patients with PAI and SAI ( 5 , 6 ).…”

Section: Discussionsupporting

confidence: 46%

“…All 3 subscales are considered to have excellent temporal stability and internal consistency in clinical samples. Cronbach’s alpha for the depression, anxiety, and stress subscales in clinical samples have been reported at 0.96, 0.89, and 0.93, respectively ( 17 ). The total depression subscale score was divided into normal (0-9), mild depression (10-13), moderate depression (14-20), severe depression (21-27), and extremely severe depression (28-42).…”

Section: Methodsmentioning

confidence: 99%

“…However, only a small proportion of the patients (4%) underwent COVID-19 confirmatory testing. Another cross-sectional survey study of 121 patients focusing on psychological stress, also in Italy from February to April 2020, reported a prevalence of COVID-19 infection as 0.8%, with patients’ concerns on personal health, finances, and quality of life ( 17 ). Both of the studies were limited by a small sample size, monocentric design within a single European country, assessment during the early stage of the pandemic, and lack of comparison to the prepandemic care.…”

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confidence: 99%

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The Impact of the COVID-19 Pandemic on Self-Reported Outcomes in Patients With Adrenal Insufficiency

Suresh

Abbondanza

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context The COVID-19 pandemic has impacted healthcare environment. Objective To determine the impact of the pandemic on self-reported outcomes in patients with adrenal insufficiency (AI). Design and setting Prospective longitudinal survey study at 2 tertiary centers. Participants Patients with AI. Intervention Patient-centered questionnaire. Main outcome measures Depression Anxiety Stress Scales-21, Short Form-36, and AI self-management. Results Of 342 patients, 157 (46%) had primary AI, 109 (32%) had secondary AI, and 76 (22%) had glucocorticoid-induced AI. When compared to prepandemic, daily glucocorticoid dose and number of adrenal crises did not change. However, patients reported a higher financial impact from AI (34% vs 23%, P = 0.006) and difficulty accessing medical care (31% vs 7%, P < 0.0001) during the pandemic. A third of patients reported difficulty managing AI during the pandemic. After adjusting for duration and subtypes of AI, younger patients [odds ratio (OR) 2.3, CI 95% 1.3-4.1], women (OR 3.7, CI 95% 1.9-7.1), poor healthcare access(OR 4.2, CI 95% 2.3-7.7), lack of good insurance support (OR 2.8, CI 95% 1.3-5.9), and those with a higher financial impact (OR 2.3, CI 95% 1.3-4.3) reported greater difficulties managing AI. Patients were more likely to report a higher anxiety score (≥8) if they found managing AI challenging during the pandemic (OR 3.0, CI 95% 1.3-6.9), and had lower Physical Component Summary (OR 4.9, CI 95% 2.2-11.0) and Mental Component Summary (OR 4.1, CI 95% 1.8-9.5) scores prior to the pandemic. Conclusions A third of patients with AI reported difficulties with management of AI during the pandemic, particularly in younger patients, women, and those with poor healthcare access.

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Section: Discussionsupporting

confidence: 46%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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The Impact of the COVID-19 Pandemic on Self-Reported Outcomes in Patients With Adrenal Insufficiency

Suresh

Abbondanza

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Questo, diventando quantificabile per l'endocrinologo, permette un adeguamento della terapia sostitutiva tempestivo e consapevole così da prevenire sia crisi surrenaliche estremamente pericolose, sia eventuali trattamenti eccessivi fai-da-te. Non si può escludere, infatti, che i risultati dello studio [13] siano anche frutto dell'influenza positiva che tale indagine osservazionale ha avuto sul paziente, in virtù della percezione di "intervento" resa rispetto alla condizione di isolamento e abbandono relativa alla pandemia.…”

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Impatto della pandemia da COVID-19 sullo stress psicofisico nei pazienti con insufficienza surrenalica

Spagnolo¹,

Trimarchi

2021

L'Endocrinologo

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“…In one Italian survey of 121 patients with AI (n = 40 with primary AI, and n = 81 with secondary AI), COVID-19 was reported in one patient with primary AI, that is, 0.8% prevalence. [3] The main purpose of this manuscript is to review all pertinent studies that evaluated AI among patients with COVID-19. These studies included case reports, imaging, and autopsy investigations.…”

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confidence: 99%

Assessment of Adrenal Function in COVID-19

Mikhail¹,

Wali²

2020

J Pathol Infect Dis

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A drenal insufficiency (AI) is a treatable disorder that can be life-threatening if its diagnosis is missed. [1] Many symptoms and signs of AI may overlap with those of coronavirus disease 2019 (COVID-19) such as hypotension, diarrhea, vomiting, and hyponatremia. [1,2] Unfortunately, the status of adrenal function is unclear in COVID-19. In turn, in patients who already have AI, the prevalence of COVID-19 is unknown. In one Italian survey of 121 patients with AI (n = 40 with primary AI, and n = 81 with secondary AI), COVID-19 was reported in one patient with primary AI, that is, 0.8% prevalence. [3] The main purpose of this manuscript is to review all pertinent studies that evaluated AI among patients with COVID-19. These studies included case reports, imaging, and autopsy investigations. CASE REPORTSOnly 4 case reports were found in the literature that described new-onset AI in patients with COVID-19. [4][5][6][7] Overview of these reports is summarized in Table 1. In the first case Frankel et al. [4] from Israel reported a 66-yearold woman with a history of primary antiphospholipid syndrome (APLS) who was hospitalized for COVID-19. Her main symptoms included diffuse abdominal tenderness due to bilateral adrenal hemorrhage. [4] AI was confirmed by undetectable serum cortisol levels that failed to respond to stimulation by a synthetic adrenocorticotrophic hormone (ACTH). [4] The authors attributed this case of primary AI to adrenal hemorrhage due to thrombosis of adrenal veins caused both by APLS and COVID-19. [4] In the second report from France, Maria et al. [5] described another patient with primary APLS who also presented with abdominal pain in addition to diffuse thrombosis in the lower extremity. However, the MINI-REVIEW

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Impact of COVID-19 Pandemic on Psychophysical Stress in Patients with Adrenal Insufficiency: The CORTI-COVID Study

Cited by 4 publications

References 0 publications

The Impact of the COVID-19 Pandemic on Self-Reported Outcomes in Patients With Adrenal Insufficiency

The Impact of the COVID-19 Pandemic on Self-Reported Outcomes in Patients With Adrenal Insufficiency

Impatto della pandemia da COVID-19 sullo stress psicofisico nei pazienti con insufficienza surrenalica

Assessment of Adrenal Function in COVID-19

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