Impact of crystalline domains on long‐term stability and mechanical performance of anisotropic silk fibroin sponges
Elizabeth L. Aikman,
Asha P. Rao,
Yinhao Jia
et al.
Abstract:Sponge‐like materials made from regenerated silk fibroin biopolymers are a tunable and advantageous platform for in vitro engineered tissue culture and in vivo tissue regeneration. Anisotropic, three‐dimensional (3D) silk fibroin sponge‐like scaffolds can mimic the architecture of contractile muscle. Herein, we use silk fibroin solution isolated from the cocoons of Bombyx mori silkworms to form aligned sponges via directional ice templating in a custom mold with a slurry of dry ice and ethanol. Hydrated tensil… Show more
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