Impact of curcumin nanoformulation on its antimicrobial activity

Silva, Anderson Clayton da; Santos, Priscila Dayane de Freitas; Silva, Jéssica Thaís do Prado; Leimann, Fernanda Vitória; Bracht, Lívia; Gonçalves, Odinei Hess

doi:10.1016/j.tifs.2017.12.004

Cited by 123 publications

(61 citation statements)

References 75 publications

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“…Furthermore, it has been published that curcumin can induce some physical and mechanical changes of the S. Typhimurium agellar lament, causing a decrease in motility, adherence, and invasion of the host cells, which results in a reduction or elimination of its virulence [49]. Likewise, curcumin has been reported to decrease bacterial cell division processes since it interacts with the FtsZ protein, a cytoskeleton protein essential for this process [50]. Meanwhile, the treatment containing the mixture of CA and CR (CA-CR) was slightly more effective in reducing the S. Typhimurium concentration compared to the group treated with CR and the PC group (2% and 37%, respectively).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Curcumin and Copper Acetate Against Salmonella Typhimurium Infection, Intestinal Permeability, and Cecal Microbiota Composition in Broiler Chickens

Leyva-Diaz

Hernández-Patlán

Solís-Cruz

et al. 2020

Preprint

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Background: Interest in the use of natural feed additives as an alternative to antimicrobials in the poultry industry has increased in recent years because of the risk of bacterial resistance. One of the most studied groups are polyphenolic compounds, given their advantages over other types of additives and their easy potentiation of effects when complexes are formed with metal ions. Therefore, the objective of the present study was to evaluate the impact of dietary supplementation of Copper Acetate (CA), Curcumin (CR), and their combination (CA-CR) against Salmonella Typhimurium colonization, intestinal permeability, and cecal microbiota composition in broiler chickens.Results: The obtained results showed that in two independent studies, all experimental treatments were able to significantly reduce the S. Typhimurium colonization in cecal tonsils (CT, p < 0.05) compared to the positive control (PC) group. However, CR and CA-CR were the best treatments reducing S. Typhimurium counts. Furthermore, the serum fluorescein isothiocyanate dextran (FITC-d) concentration in chickens treated with CR was significantly lower when compared to PC (p < 0.05). The effect of dietary treatments in reducing S. Typhimurium colonization was further supported by the Linear discriminant analysis effect size (LEfSe) analysis of microbiome data, where Salmonella was significantly enriched in PC group (LDA score > 2.0 and p<0.05). In addition, Coprobacillus, Eubacterium, and Clostridium were significantly higher in the PC group compared to other treatment groups. On the contrary, Fecalibacterium and Enterococcus at CR, unknown genus of Erysipelotrichaceae at CA-CR, and unknown genus of Lachnospiraceae at CA were significantly abundant respectively.Conclusions: CR treatment was the most effective treatment to reduce S. Typhimurium intestinal colonization and intestinal permeability associated with variations in the cecae microbiota structure in broiler chickens.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Curcumin and Copper Acetate Against Salmonella Typhimurium Infection, Intestinal Permeability, and Cecal Microbiota Composition in Broiler Chickens

Leyva-Diaz

Hernández-Patlán

Solís-Cruz

et al. 2020

Preprint

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“…1). In addition, as it occurs with citral, linalool is active against a fluconazole-resistant fungus strain, Trychophyton rubrum (14).…”

Section: Terpenoids and Essential Oilsmentioning

confidence: 99%

“…This antifungal activity could reside in the induction of alterations of membrane-associated ATPases, ergosterol biosynthesis inhibition, and reduction in the levels of proteinase secretion, an important virulence factor (60,95). However, curcumin is insoluble in water, so it must be microencapsulated to be used as a preservative in food, thereby increasing the solubility and antifungal effect of curcumin (14,31).…”

Section: Polyphenolsmentioning

confidence: 99%

Plant Phytochemicals in Food Preservation: Antifungal Bioactivity: A Review

Redondo-Blanco

Fernández

López-Ibáñez

et al. 2020

Journal of Food Protection

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Synthetic food additives generate a negative perception in consumers. This fact generates an important pressure on food manufacturers, searching for safer natural alternatives. Phytochemicals (such as polyphenols and thiols) and plant essential oils (terpenoids) possess antimicrobial activities that are able to prevent food spoilage due to fungi (e.g., Aspergillus, Penicillium) and intoxications (due to mycotoxins), both of which are important economic and health problems worldwide. This review summarizes industrially interesting antifungal bioactivities from the three main types of plant nutraceuticals: terpenoids (as thymol), polyphenols (as resveratrol) and thiols (as allicin) as well as some of the mechanisms of action. These phytochemicals are widely distributed in fruits and vegetables and are very useful in food preservation as they inhibit growth of important spoilage and pathogenic fungi, affecting especially mycelial growth and germination. Terpenoids and essential oils are the most abundant group of secondary metabolites found in plant extracts, especially in common aromatic plants, but polyphenols are a more remarkable group of bioactive compounds as they show a broad array of bioactivities. HIGHLIGHTS

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“…Curcumin has shown antimicrobial activity in vitro against a wide range of microbes, including several pathogenic gram‐positive bacteria such as Bacillus cereus , Bacillus subtilis , Staphylococcus aureus , Streptococcus mutans , Staphylococcus epidermidis, and gram‐negative bacteria such as Escherichia coli , Pseudomonas aeruginosa , Yersinia enterocolitica, and Shigella dysenteriae , as well as funguses such as Aspergillus níger , Candida albicans, and Penicillium notatum and molds . Gram‐positive bacteria show a significantly higher sensitivity to curcumin than the gram‐negative bacteria.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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Impact of curcumin nanoformulation on its antimicrobial activity

Cited by 123 publications

References 75 publications

Evaluation of Curcumin and Copper Acetate Against Salmonella Typhimurium Infection, Intestinal Permeability, and Cecal Microbiota Composition in Broiler Chickens

Evaluation of Curcumin and Copper Acetate Against Salmonella Typhimurium Infection, Intestinal Permeability, and Cecal Microbiota Composition in Broiler Chickens

Plant Phytochemicals in Food Preservation: Antifungal Bioactivity: A Review

Biological properties of metal complexes of curcumin

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