Impact of dairy consumption on essential hypertension: a clinical study

Drouin‐Chartier, Jean‐Philippe; Gigleux, Iris; Tremblay, André; Poirier, Luc; Lamarche, Benoı̂t; Couture, Patrick

doi:10.1186/1475-2891-13-83

Cited by 37 publications

(29 citation statements)

References 33 publications

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“…The study cohort included 221 men covering a wide range of adiposity and glucose homeostasis values. Participants were recruited through the Institute of Nutrition and Functional Food (INAF) clinical unit (Laval University) in the context of several research projects [23][24][25][26][27][28][29][30][31][32][33][34]. Exclusion criteria included smoking, cardiovascular disease, cancer history, monogenic lipid disorder, altered endocrine or hepatic function, gastrointestinal disease, HIV infection, alcoholism and severe dyslipidemia.…”

Section: Study Populationmentioning

confidence: 99%

Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations

Lalande

Drouin‐Chartier

Tremblay

et al. 2020

Diabetol Metab Syndr

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Background: Evidence suggests that pathophysiological conditions such as obesity and type 2 diabetes (T2D) are associated with morphologic and metabolic alterations in the small intestinal mucosa. Exploring these alterations generally requires invasive methods, limiting data acquisition to subjects with enteropathies or undergoing bariatric surgery. We aimed to evaluate small intestine epithelial cell homeostasis in a cohort of men covering a wide range of adiposity and glucose homoeostasis statuses. Methods: Plasma levels of citrulline, a biomarker of enterocyte mass, and I-FABP, a biomarker of enterocyte death, were measured by UHPLC-MS and ELISA in 154 nondiabetic men and 67 men with a T2D diagnosis. Results: Plasma citrulline was significantly reduced in men with insulin resistance and T2D compared to insulin sensitive men. Decreased citrulline levels were, however, not observed in men with uncontrolled metabolic parameters during T2D. Plasma I-FABP was significantly higher in men with T2D, especially in presence of uncontrolled glycemic and lipid profile parameters. Integration of both parameters, which estimate enterocyte turnover, was associated with glucose homeostasis as well as with T2D diagnosis. Differences in biomarkers levels were independent of age and BMI and glucose filtration rates. Conclusions: Our study supports a decreased functional enterocyte mass and an increased enterocyte death rate in presence of metabolic alterations but emphasizes that epithelial cell homeostasis is especially altered in presence of severe insulin resistance and T2D. The marked changes in small intestine cellularity observed in obesity and diabetes are thus suggested to be part of gut dysfunctions, mainly at an advanced stage of the disease.

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Section: Study Populationmentioning

confidence: 99%

Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations

Lalande

Drouin‐Chartier

Tremblay

et al. 2020

Diabetol Metab Syndr

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“…In their meta-analysis, Benatar et al (14) reported no significant effect of total dairy intake on systolic and diastolic BP. Additional RCTs in hypertensive subjects provided mixed results regarding the impact of high dairy intake compared with low or no dairy over periods of 4–5 wk on BP outcomes (57–59). Two studies saw no effect of dairy intake on systolic and diastolic BP (57, 58), whereas we reported that consumption of 3 daily servings of regular-fat dairy (30 g regular-fat cheddar cheese/d, 175 g 1.5%-fat yogurt/d, and 375 mL 1% fat milk/d) significantly reduced mean daytime systolic BP compared with a dairy-free control diet in men (mean ± SD: 142 ± 10 compared with 144 ± 10 mm Hg, P = 0.05) (59).…”

Section: Dairy and Cardiometabolic Disease Risk Factorsmentioning

confidence: 99%

“…Additional RCTs in hypertensive subjects provided mixed results regarding the impact of high dairy intake compared with low or no dairy over periods of 4–5 wk on BP outcomes (57–59). Two studies saw no effect of dairy intake on systolic and diastolic BP (57, 58), whereas we reported that consumption of 3 daily servings of regular-fat dairy (30 g regular-fat cheddar cheese/d, 175 g 1.5%-fat yogurt/d, and 375 mL 1% fat milk/d) significantly reduced mean daytime systolic BP compared with a dairy-free control diet in men (mean ± SD: 142 ± 10 compared with 144 ± 10 mm Hg, P = 0.05) (59). Unexpectedly, mean daytime diastolic BP was higher after the dairy diet than after the control phase in women (mean ± SD: 85 ± 9 compared with 84 ± 8 mm Hg, P = 0.05), but not in men (59).…”

Section: Dairy and Cardiometabolic Disease Risk Factorsmentioning

confidence: 99%

Comprehensive Review of the Impact of Dairy Foods and Dairy Fat on Cardiometabolic Risk

Drouin‐Chartier¹,

Côté

Labonté

et al. 2016

Advances in Nutrition

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120

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Because regular-fat dairy products are a major source of cholesterol-raising saturated fatty acids (SFAs), current US and Canadian dietary guidelines for cardiovascular health recommend the consumption of low-fat dairy products. Yet, numerous randomized controlled trials (RCTs) have reported rather mixed effects of reduced- and regular-fat dairy consumption on blood lipid concentrations and on many other cardiometabolic disease risk factors, such as blood pressure and inflammation markers. Thus, the focus on low-fat dairy in current dietary guidelines is being challenged, creating confusion within health professional circles and the public. This narrative review provides perspective on the research pertaining to the impact of dairy consumption and dairy fat on traditional and emerging cardiometabolic disease risk factors. This comprehensive assessment of evidence from RCTs suggests that there is no apparent risk of potential harmful effects of dairy consumption, irrespective of the content of dairy fat, on a large array of cardiometabolic variables, including lipid-related risk factors, blood pressure, inflammation, insulin resistance, and vascular function. This suggests that the purported detrimental effects of SFAs on cardiometabolic health may in fact be nullified when they are consumed as part of complex food matrices such as those in cheese and other dairy foods. Thus, the focus on low-fat dairy products in current guidelines apparently is not entirely supported by the existing literature and may need to be revisited on the basis of this evidence. Future studies addressing key research gaps in this area will be extremely informative to better appreciate the impact of dairy food matrices, as well as dairy fat specifically, on cardiometabolic health.

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“…Commercial packaging was added in addition to the serving plate, when relevant. To help determining the range of portion sizes, we consulted the most frequently chosen portion-size images of 91 food items by 966 adult participants from studies conducted at our research center [28,29,30,31,32,33,34,35,36,37], in which a web-based food-frequency questionnaire (FFQ) was completed [38]. In the FFQ, in addition to portion-size images, there was an option to select an amount that was less than the smallest portion size (“−“ option) or more than the biggest portion size (“+” option).…”

Section: Methodsmentioning

confidence: 99%

Development of a Web-Based 24-h Dietary Recall for a French-Canadian Population

et al. 2016

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Twenty-four-hour dietary recalls can provide high-quality dietary intake data, but are considered expensive, as they rely on trained professionals for both their administration and coding. The objective of this study was to develop an automated, self-administered web-based 24-h recall (R24W) for a French-Canadian population. The development of R24W was inspired by the United States Department of Agriculture (USDA) Automated Multiple-Pass Method. Questions about the context of meals/snacks were included. Toppings, sauces and spices frequently added to each food/dish were suggested systematically. A list of frequently forgotten food was also suggested. An interactive summary allows the respondent to track the progress of the questionnaire and to modify or remove food as needed. The R24W prototype was pre-tested for usability and functionality in a convenience sample of 29 subjects between the ages of 23 and 65 years, who had to complete one recall, as well as a satisfaction questionnaire. R24W includes a list of 2865 food items, distributed into 16 categories and 98 subcategories. A total of 687 recipes were created for mixed dishes, including 336 ethnic recipes. Pictures of food items illustrate up to eight servings per food item. The pre-test demonstrated that R24W is easy to complete and to understand. This new dietary assessment tool is a simple and inexpensive tool that will facilitate diet assessment of individuals in large-scale studies, but validation studies are needed prior to the utilization of the R24W.

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Impact of dairy consumption on essential hypertension: a clinical study

Cited by 37 publications

References 33 publications

Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations

Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations

Comprehensive Review of the Impact of Dairy Foods and Dairy Fat on Cardiometabolic Risk

Development of a Web-Based 24-h Dietary Recall for a French-Canadian Population

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