Impact of data-driven cardiac respiratory motion correction on the extent and severity of myocardial perfusion defects with free-breathing CZT SPECT

Daou, Doumit; Sabbah, R.; Coaguila, Carlos; Boulahdour, Hatem

doi:10.1007/s12350-017-0806-2

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…Then a motion corrected image was generated by combining all the registered images. Similar as the findings for respiratory motion in (Daou et al 2018), body motion >10 mm with >60 s in duration introduced significant artifacts on perfusion images. The proposed motion correction method effectively removed the artifacts in most of the cases, using the total perfusion deficit as the figure of merit.…”

Section: Data-driven Motion Estimationsupporting

confidence: 80%

“…Clinical studies using such data-driven approaches showed that the respiratory motion amplitude of the heart is larger than 10 mm in 55% of patients. All motion compensation showed a frequent impact on the extent and severity of perfusion defects based on the evaluation using a 5-level scoring system on the 17-segment LV model, particularly for patients with >10 mm motion amplitude (Daou et al 2018). In addition to tracking respiratory motion, similar data-driven approaches with centroid determination from rebinned frames can also be used to track body motion.…”

Section: Data-driven Motion Estimationmentioning

confidence: 99%

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Recent advances in cardiac SPECT instrumentation and imaging methods

Liu

2019

Phys. Med. Biol.

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Cardiac SPECT continues to play a critical role in detecting and managing cardiovascular disease, in particularly coronary artery disease (CAD) (Jaarsma et al 2012 J. Am. Coll. Cardiol. 59 1719–28), (Agostini et al 2016 Eur. J. Nucl. Med. Mol. Imaging 43 2423–32). While conventional dual-head SPECT scanners using parallel-hole collimators and scintillation crystals with photomultiplier tubes are still the workhorse of cardiac SPECT, they have the limitations of low photon sensitivity (~130 count s−1 MBq−1), poor image resolution (~15 mm) (Imbert et al 2012 J. Nucl. Med. 53 1897–903), relatively long acquisition time, inefficient use of the detector, high radiation dose, etc. Recently our field observed an exciting growth of new developments of dedicated cardiac scanners and collimators, as well as novel imaging algorithms for quantitative cardiac SPECT. These developments have opened doors to new applications with potential clinical impact, including ultra-low-dose imaging, absolute quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR), multi-radionuclide imaging, and improved image quality as a result of attenuation, scatter, motion, and partial volume corrections (PVCs). In this article, we review the recent advances in cardiac SPECT instrumentation and imaging methods. This review mainly focuses on the most recent developments published since 2012 and points to the future of cardiac SPECT from an imaging physics perspective.

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Section: Data-driven Motion Estimationsupporting

confidence: 80%

Section: Data-driven Motion Estimationmentioning

confidence: 99%

Recent advances in cardiac SPECT instrumentation and imaging methods

Liu

2019

Phys. Med. Biol.

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“…RM correction is thus desirable in order to fully benefit from the high spatial resolution of CZT systems. In this context, Daou et al proposed an innovative data-driven method for RM correction and studied its impact on the extent and severity of myocardial perfusion defects observed with free-breathing CZT SPECT (3)(4)(5).…”

Section: Respiratory Motion Correction In Mpimentioning

confidence: 99%

One Year of Nuclear Cardiology in France

Bouallègue

Denis

2017

Annals of Nuclear Cardiology

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The present paper provides an overview of selected articles published by French research teams that are representative of recent advances in the field of nuclear cardiology, particularly in connection with the advent of new dedicated cardiac CZT cameras. The topics discussed here cover the impact of respiratory motion correction in myocardial perfusion imaging, global and regional LV function assessment using CZT cameras, innovative approaches in MIBG imaging, and RV function analysis by means of gated blood pool SPECT. Keywords Respiratory motion correction in MPIRecently, a new generation of dedicated cardiac CZT SPECT gamma cameras has been commercialized. These cameras offer higher count sensitivity and spatial resolution with comparison to classical Anger cameras, allowing faster myocardial perfusion imaging protocols and significant reduction in injected activities (1, 2) (see Fig. 1). In addition, data are acquired dynamically in list-mode synchronized to ECG, opening the way to easier handling of patient motion.Respiratory motion (RM) of the thoraco-abdominal organs may introduce blurring and artefacts into the images and impact MPI performances. RM correction is thus desirable in order to fully benefit from the high spatial resolution of CZT systems. In this context, Daou et al. proposed an innovative data-driven method for RM correction and studied its impact on the extent and severity of myocardial perfusion defects observed with free-breathing CZT SPECT (3-5).The proposed method relied on the rebinning of list-mode data to generate a dynamic SPECT acquisition consisting of 500 ms time frames over 5 minutes. Dynamic images were post-processed to produce a data-driven RM curve using a statistical method adapted to low signal-to-noise ratio data.RM gated images were then reconstructed and summed after rigid realignment based on normalized cross-correlation (3).The technique was validated in 25 patients with known or suspected CAD having a 1-day 99m Tc-tetrofosmin stress/rest MPI using a Discovery NM 530c camera (5). Tracer uptake was rated using both visual and semi-quantitative analyses and RM correction was considered as having an impact if at least one myocardial segment presented a severity score changing by at least one level. Cardiac RM was significant in most of the MPI studies, especially in male patients and in stress acquisitions, and predominated along the anterior-inferior axis. RM correction had an impact on qualitative and

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“…The impact on myocardial perfusion defect appears when . When , myocardial perfusion defects concern 14% of the CZT-SPECT [14,15]. A study on motion correction concluded that RM have an in uence on the diagnostic result, but not PM [16].…”

Section: Introductionmentioning

confidence: 99%

Improving multi-pinhole CZT myocardial perfusion imaging specificity without changing sensibility by using adapted prefilter parameters

Vauchot,

Dubois,

Bourdon

2023

Preprint

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Background Meta-analysis show the diagnostic performance of cardiac dedicated multi-pinhole CZT (cadmium-zinc-telluride) myocardial perfusion imaging (MPI) with a sensibility around 0.9 and a specificity around 0.7. The aim of the present study is to explore a simple method to generate less artefact on MPI using single photon emission computed tomography (SPECT) and to enhance specificity without changing sensibility. Results From October 2018 to March 2019, 200 patients who underwent SPECT with [99mTc]Tc-tetrofosmin were prospectively recruited: 100 patients with ischemia or necrosis diagnosis (first arm), and 100 patients with myocardial reversible SPECT artefact (second arm). Each SPECT was explored using two image process based on a Butterworth prefilter: the original image processing (treatment A) with a cut-off frequency equals to 37% of the Nyquist frequency and order equals to 7, and a second image processing (treatment B) with a cut-off frequency equals to 25% of the Nyquist frequency and order equals to 5. For each patient, sum stress or rest score with and without septum (SSRS and SSRSws) were calculated with the two treatments. No significant statistical difference between SSRSa and SSRSb was identified for the first arm (P=0.54) and the relative difference ∆r was -0.5 ± 11.1 % (CI95 -2.6–1.8). We found a significant statistical difference between SSRSa and SSRSb for the second arm (p < 0.0001). Conclusion In conclusion, using a prefilter cut-off frequency equal to 25% of the Nyquist frequency before iterative reconstruction generates less artefact and improves myocardial SPECT specificity without affecting sensibility compared with the original treatment.

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Impact of data-driven cardiac respiratory motion correction on the extent and severity of myocardial perfusion defects with free-breathing CZT SPECT

Abstract: A substantial number of MPI studies presented significant cardiac RM. Cardiac RM compensation showed a frequent impact on the extent/severity of MPD.

Cited by 10 publications

References 30 publications

Recent advances in cardiac SPECT instrumentation and imaging methods

Recent advances in cardiac SPECT instrumentation and imaging methods

One Year of Nuclear Cardiology in France

Improving multi-pinhole CZT myocardial perfusion imaging specificity without changing sensibility by using adapted prefilter parameters

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