This study presented the blast behavior of flood-defense structures subjected to high-intensity loadings such as blast shock waves. In order to understand the blast behavior of weir structures, PHAST program was used to predict blast loadings in consideration of material reactivity and congestion levels. Environment factors such as weather data and atmospheric parameters were also considered in this study. Then, nonlinear dynamic analyses were performed using the ABAQUS platform to evaluate structural responses and blast vibration of concrete weir structures subjected to various types of blast loadings, due to uncertainties of the magnitude and durations of blast loads as a function of distance from the explosion. It was shown that the blast damage to concrete weir structure was significantly influenced by congestion levels or material reactivity. Also, the stress concentration under blast loading was observed at the connection area between the concrete weir body and stilling basin.