Impact of Decentralized Pharmacokinetics Consultation Service

Winter, Michael E.; Herfindal, Eric T.; Bernstein, Linda R.

doi:10.1093/ajhp/43.9.2178

Cited by 10 publications

(13 citation statements)

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“…The benefits of pharmacists and clinical pharmacy services in individual practice sites have been well documented, as have the benefits of pharmacists' involvement in the management of patients receiving aminoglycoside or vancomycin, including therapeutic outcomes; decreased costs, hospitalizations, and complications; and other outcomes. [39][40][41][42][43][44][45][46] However, no studies have been published evaluating the effect of pharmacist-managed aminoglycoside or vancomycin across multiple hospitals or large patient populations. Studies involving large numbers of patients are critical for several reasons.…”

Section: Reportsmentioning

confidence: 99%

Clinical and economic outcomes of pharmacist-managed aminoglycoside or vancomycin therapy

Bond¹,

Raehl

2005

American Journal of Health-System Pharmacy

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Section: Reportsmentioning

confidence: 99%

Clinical and economic outcomes of pharmacist-managed aminoglycoside or vancomycin therapy

Bond¹,

Raehl

2005

American Journal of Health-System Pharmacy

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“…Several other recent evaluations (Bailie & Mathews 1988b;Hoffa 1989;Quebbeman et al 1985;Winter et al 1986) have also documented similar improvements in the quality of serum concentration monitoring and dosage adjustments of aminoglycoside antibiotics.…”

Section: Cost-effectiveness Of Serum Concentration Feedbackmentioning

confidence: 65%

An Updated Comparison of Drug Dosing Methods

Erdman

Rodvold

Pryka

1991

Clinical Pharmacokinetics

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Aminoglycoside antibiotics continue to be useful for the treatment of Gram-negative infections. Available dosing methods include predictive algorithms and nomograms, pharmacokinetics-based dosing methods, and methods that incorporate Bayesian forecasting. The individualised Sawchuk-Zaske and Bayesian methods have been extensively evaluated since the previous review in the Journal. Both methods continue to be rapid and accurate means of individualising dosage requirements for patients with diverse pharmacokinetic profiles. The predictive performance of the Bayesian method can be further enhanced when population-based parameters reflect the patient population being monitored. There are now several cost-effectiveness studies that demonstrate that pharmacokinetic dosing services for aminoglycosides result in cost savings, better therapeutic concentrations, fewer toxic serum concentrations, and shorter mean durations of hospital stay and aminoglycoside therapy. Further studies are needed for cost-effectiveness and comparison of various dosing methods in paediatric and neonatal patients.

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“…A study by Winter et al (1986) evaluated the effects of pharmacokinetic consultations on the quality of drug therapy in patients receiving either an aminoglycoside or theophylline. Data were collected retrospectively for 3 periods: 3 months before, 4 months during and 3 months after a period of intervention by a pharmacist.…”

Section: Cost-effectiveness Of Using Feedbackmentioning

confidence: 99%

An Updated Comparison of Drug Dosing Methods

Erdman

Rodvold

Pryka

1991

Clinical Pharmacokinetics

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This article updates the previous review in the Journal regarding theophylline dosing methods. Among the predictive algorithms evaluated, the dose-titration scheme of Weinberger and Hendeles was extensively tested in 1073 asthmatic patients. When the scheme was followed appropriately, 78% of initial serum concentrations and 66% of repeat serum concentrations were within the therapeutic range of 10 to 20 mg/L. Several authors have also demonstrated that the 'condition correction factor' method for estimating theophylline clearance is of limited value. The individualised methods of Chiou, Koup and Vozeh have been evaluated in over 300 patients. In addition, numerous authors have reported the relative predictive performance of Bayesian dosing programs for theophylline. All methods continue to be a rapid and accurate means of individualizing dosing requirements for patients with a diverse range of theophylline disposition characteristics. Overall, the Bayesian predictions have been less biased and slightly more precise than the pharmacokinetics-based dosing methods. The most recent cost-effectiveness data has shown that a pharmacokinetic dosing program resulted in fewer toxic serum concentrations (18.9% vs 37.8%), a shorter mean duration of hospital stay (6.3 vs 8.7 days) and more therapeutic concentrations with subsequent oral therapy (71.1% vs 44.4%) than among control patients receiving dosages prescribed by physicians.

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Impact of Decentralized Pharmacokinetics Consultation Service

Cited by 10 publications

References 0 publications

Clinical and economic outcomes of pharmacist-managed aminoglycoside or vancomycin therapy

Clinical and economic outcomes of pharmacist-managed aminoglycoside or vancomycin therapy

An Updated Comparison of Drug Dosing Methods

An Updated Comparison of Drug Dosing Methods

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