The aim of the presented paper is to examine the specific situation in the institutional provision of tourism in Slovakia with special regard to the most important and in the crisis period the most vulnerable tourism regions, their identification is a partial goal of the paper. With regard to the current crisis period, the survey is supplemented by identifying factors of employment change, focusing mainly on the region’s competitiveness in tourism. The importance of regions is assessed in the article on the basis of potential for tourism development, further in terms of their importance for tourism in Slovakia based on tourism performance expressed by the number of overnight stays and on the basis of industry concentration of tourism measured by employment in tourism. We consider the most vulnerable regions to be those that reach the level of specialization in tourism (based on the localization coefficient) and it has a growing tendency. The research results show that the importance of regional competitiveness in tourism for employment change (which is a regional component) is very different despite the established destination management, it is even negative, and in the case of positive figures, it is without an obvious advantage over other factors analyzed in the shift-share analysis. Also, it is possible that the current crisis period caused by measures in connection with the COVID-19 pandemic will help to find endogenous solutions to fragmented destination management in the most important and vulnerable tourism regions, or legislative solutions related to the amendment to the Tourism Promotion Act.