Impact of Deep Brain Stimulation on Gait in Parkinson Disease: A Kinematic Study

A Data-driven Exploration and Prediction of Deep Brain Stimulation Effects on Gait in Parkinson's Disease

“…However, some studies [33], [35], [49] have found an opposite trend, suggesting that these changes may primarily manifest during short follow-up periods (e.g., three months), then may diminish over longer observation windows. The main explanation for such behaviour could be the natural progression of the disease [18], [33], [41].…”

“…This change is regarded overall as a positive response to STN-DBS and appears to be even more evident when electrical stimulation is coupled with Levodopa [45], [47], [48]. However, some studies [33], [35], [49] have found an opposite trend, suggesting that these changes may primarily manifest during short follow-up periods (e.g., three months), then may diminish over longer observation windows. The main explanation for such behaviour could be the natural progression of the disease [18], [33], [41].…”

“…A plethora of works have investigated the effects of STN-DBS on walking patterns before and after surgery, by exploiting motion capture systems [29], [33]- [39]. However, these studies often present mixed and contradictory results.…”