Acute delirium is very common among hospital patients, particularly older patients. Nurses have a major role in the care of these patients, yet there are no evidence-based nursing care guidelines to help nurses detect patients who are experiencing acute delirium, safeguard them, and assist their recovery. This study sought to identify and prioritize nursing practices for detecting these patients, safeguarding them, and assisting their recovery from acute delirium. A two-stage voluntary paper Delphi survey was used for this purpose. This study targeted all nurses who worked on adult medical/surgical units at two full-service acute care hospitals in Western Canada Global Journal of Health Science www.ccsenet.org/gjhs 82 who had cared for a patient diagnosed with acute delirium in the past 12 months. The first survey revealed many nursing practices exist to detect, safeguard, and assist recovery. The second revealed one preferred practice and four others for each of the following: Detecting acute delirium, safeguarding patients, and helping patients recover. Research is now needed to establish if these constitute "best practice" nursing care for enhanced patient outcomes.Keywords: Acute delirium, Confusion, Delphi technique, Hospital care, Nursing practice, Survey Acute delirium is common among hospital patients, although it is often unrecognized or misdiagnosed (Morandi et al., 2009). Acute delirium is therefore typically under reported (Kales, Kamholz, Visnic & Blow, 2003, Minden et al., 2005. Regardless, acute delirium is clearly understood as a serious health condition. It is associated with prolonged hospital stays, long-standing (if not permanent) cognitive impairment, high risk of nursing home admission, and death (Gonzalez et al., 2009;MacLullich, Beaglehole, Hall & Meagher, 2009). Many studies have sought to identify the incidence or prevalence of acute delirium, its many causes, and its medical management. Few studies have focused on the nursing perspective, yet nurses are the most likely healthcare professional to detect patients who are experiencing acute delirium. Nurses are also responsible for planning and managing the day-to-day care of these patients with a need to be kept safe and a need for nursing care that will help them recover.No studies were found through a systematic review of acute delirium research that reveal how nurses identify patients who are experiencing acute delirium, what they do to safeguard these patients, and what they do to help them recover. This research gap lends credence to the assertion of Rapp, Mentes, and Titler (2001) that over half of all nursing care that is considered "appropriate" practice is not evidence based. The need for nurse researchers to focus on acute delirium was pointed out many years ago. In 1996, Meagher, O'Hanlon, O'Mahony, and Casey emphasized the importance of early nursing identification of patients who are confused, as well as the need for best-practice nursing care for patients who are suffering from acute delirium. This lack of nursing r...