Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience

Abstract

In comparison with published ONJ rates and those extrapolated from the retrospective analysis, the observed ONJ rate in the prospective group was lower, suggesting that implementation of a preventive dental program may reduce the risk of ONJ in metastatic patients treated with i.v. BP therapy.

Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

“…tooth extraction to dental/periodontal diseases and dental/periodontal diseases) is unquestionable, also when BP should be prescribed for non-cancer indications. Recently, other Italian authors [2] have underlined the necessity of increasing the knowledge and adequate reporting of the BRONJ phenomena by health professionals, and of improving the elaboration of effective BRONJ preventive protocols [52], in order to minimize as far as possible the severe adverse effects of such an efficacious medical treatment.…”

Preventive Strategies for Patients at Risk of Medication-related Osteonecrosis of the Jaw

“…It is the investigators' opinion that patients unable to undertake preventive dental measures before bisphosphonate treatment still benefit from reaching and maintaining a stable oral condition during therapy because good oral health seems to minimize the risk of developing ONJ. 17 In the same year, Saad and colleagues 18 published a multicenter prospective trial involving 5723 patients, assessing ONJ incidence, risk factors, and outcomes in patients receiving bisphosphonates for metastatic bone disease. Tooth extraction (61.8%) was the predominant oral factor associated with the development of ONJ (1.6% of all patients).…”

Denosumab: un fármaco contra la osteoporosis puede complicar el tratamiento dental

“…El inicio del cuidado de la salud oral disminuirá la necesidad de tratamiento dental, y con ello, la incidencia de la ONM. Vandone et al, (2012), determinó que la disminución del riesgo era del 50%. Por tanto, se debe realizar un examen clínico y radiográfico, motivar y educar al paciente en materia de salud oral, realizar 214 Martínez Ferrero, M., Fernández-Tresguerres , I. Revista Complutense de Ciencias Veterinarias 11 (especial) 2017: 210-215 aplicaciones de flúor, pautar enjuagues de clorhexidina, realizar tratamiento periodontal básico si lo necesita, diagnosticar presencia de restos radiculares, caries, patología periapical, estabilidad oclusal etc.…”