Impact of Depression and Antidepressant Treatment on Heart Rate Variability: A Review and Meta-Analysis

Kemp, Andrew H.; Quintana, Daniel; Gray, Marcus A.; Felmingham, Kim L.; Brown, Kerri J.; Gatt, Justine M.

doi:10.1016/j.biopsych.2009.12.012

Cited by 1,071 publications

(1,049 citation statements)

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“…However, association of reduced HRV measures and severity of depression has been noted by Kemp et al in a meta-analysis. [19] Although sample size was limited, strength of the study was well diagnosed long-standing major depression in the study group with removal of the confounding factors like drugs with effect on HRV and finding out association of HRV derangement with the severity of depression in view of previous conflicting results.…”

Section: Discussionmentioning

confidence: 99%

Cardiac autonomic dysfunction assessed by heart rate variability in major depression

Dubey¹,

Sawane²

2017

Int J Med Sci Public Health

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Section: Discussionmentioning

confidence: 99%

Cardiac autonomic dysfunction assessed by heart rate variability in major depression

Dubey¹,

Sawane²

2017

Int J Med Sci Public Health

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“…Long term antidepressants are associated with diminished heart rate variability (Dawood et al,Antidepressants 14 2007; Kemp et al, 2010;Licht et al, 2008), another predictor of cardiovascular disease and heart attacks.…”

Section: Adverse Effects Long Termmentioning

confidence: 99%

The Controversy Over Antidepressant Drugs in an Era of Evidence-Based Practice

Littrell

Lacasse

2012

Social Work in Mental Health

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“…3 well as sympathovagal balance which represents interaction between cardiac sympathetic and parasympathetic activity 6 .…”

Section: Introductionmentioning

confidence: 99%

Autonomic Dysfunction in Major Depressive Disorder

Jahan

Begum

Ferdousi

et al. 2015

J Bangladesh Soc Physiol

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Background: Cardiovascular (CV) morbidity is a major problem in patients suffering from depression as greater CV mortality is found in cardiac patients with depression. Objective: To assess cardiac autonomic nerve activity by power spectral analysis of heart rate variability in patients with Major Depressive disorder. Methods: This case control study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka during 2011. Sixty patients of both sexes with Major Depressive disorder (MDD) aged 20-50 years were enrolled. The patients were selected from the Department of Psychiatry in Bangabandhu Sheik Mujib Medical University (BSMMU). Thirty drug naive MDD patients and thirty medicated MDD patients were compared with 30 healthy control and also between them. The HRV parameters were recorded by 4 active channels, RMS Polyrite-D. For statistical analysis independent sample t-test test was used. Results: LF norm and LF/HF were significantly higher and Total power, HF power, HF norm were significantly lower in both drug naive and medicated MDD patients in comparison with those of healthy control. Conclusion: Autonomic nerve dysfunction involved both the drug naive and medicated MDD patients which was associated with higher sympathetic activity and reduced vagal modulation of the heart and sympathovagal imbalance. Antidepressent drug treatment did not have any effect on autonomic dysfunction.

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Impact of Depression and Antidepressant Treatment on Heart Rate Variability: A Review and Meta-Analysis

Cited by 1,071 publications

References 69 publications

Cardiac autonomic dysfunction assessed by heart rate variability in major depression

Cardiac autonomic dysfunction assessed by heart rate variability in major depression

The Controversy Over Antidepressant Drugs in an Era of Evidence-Based Practice

Autonomic Dysfunction in Major Depressive Disorder

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