Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)

Onyeaka, Henry; Queeneth, Uwandu; Rashid, Wahida; Ahmad, Naveed; Rajan, Shanthini Kuduva; Jaladi, Paul Rahul; Patel, Rikinkumar S

doi:10.3390/medicina55070385

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…Our study may be underestimating the real number of patients with depression due to the underdiagnose and lack of registry of depression in the context of an acute hospitalization. These constraints have also been identified in previous studies using similar methodologies and settings 19‐21 …”

Section: Discussionsupporting

confidence: 63%

“…These constraints have also been identified in previous studies using similar methodologies and settings. [19][20][21] Moreover, an increase of registered depression was found throughout the study period. The increased quality of hospital-coded data in Portugal throughout the years may explain this results.…”

Section: Discussionmentioning

confidence: 75%

“…We observed a longer LoS in depressive patients subgroup (aOR = 1.01; 95% CI = 1.01-1.02), which is congruent with the findings of other studies, 16 including one study conducted with a sample of depressive inpatients with sickle cell disease. 19 Additionally, there is evidence that depressed MM patients present a higher number of hospitalizations and a higher mean cost of care of each hospitalization.…”

Section: Hospitalization Outcomesmentioning

confidence: 99%

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Trend of depression and its association with sociodemographic and clinical factors among multiple myeloma hospitalizations: A Portuguese nationwide study from 2000 to 2015

et al. 2020

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Objective: Patients hospitalized with multiple myeloma (MM) are particularly vulnerable to depression. The present study aims to determine the frequency of depression among MM hospitalized patients, in order to assess the possible differences between those with and without depression in relation to sociodemographic and clinical variables and to measure the impact of depression on hospitalization outcomes. Methods: An observational retrospective study was performed using an administrative data set of all hospitalizations with a primary diagnosis of MM between 2000 and 2015 in Portuguese mainland public hospitals. Codes related to depressive disorders were grouped to generate the dichotomous variable of depression (yes/no). A multivariate analysis was conducted and adjusted odd ratios (aOR) calculated between different variables and depression. Results: Of a total of 14.575 MM hospitalizations studied, a concurrent code of depression was registered in 666 patients (4.6%). A greater odds of depression was observed in female patients (aOR = 2.26; 95%CI = 1.91-2.66), transplanted patients (aOR = 1.78; 95%CI = 1.44-2.20), patients with plasma cell leukemia (aOR = 1.79; 95%CI = 1.22-2.64) and patients with a higher Charlson Comorbidity Index (CCI) (aOR = 1.10; 95%CI = 1.05-1.15). Length of stay was longer in patients with a registered diagnosis of depression (aOR = 1.01; 95%CI = 1.01-1.02) while the odds of inhospital mortality were lower in these patients (aOR = 0.53; 95%CI = 0.41-0.68). Conclusions: These results may help identify MM inpatients at higher risk of presenting depression (female gender, younger age, high CCI, plasma cell leukemia, transplant procedure). This will enable timely psychological assessment and treatment to prevent worse outcomes and higher healthcare costs associated with depression.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 75%

Section: Hospitalization Outcomesmentioning

confidence: 99%

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Trend of depression and its association with sociodemographic and clinical factors among multiple myeloma hospitalizations: A Portuguese nationwide study from 2000 to 2015

et al. 2020

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“…This study aimed to determine the prevalence and identify the relationship of sociodemographics with depression and anxiety of SCD patients at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Other researches found that depressed patients will have significantly higher health care utilization and inpatient costs than nondepressed patients [17][18][19]. So determining the risk factors that increase a psychological disorder in SCD patients will be a chance to decrease the cost and provide much better medical care to these patients.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

Al-Marzouki¹,

Alrefaie²,

Aljohani³

et al. 2021

Cureus

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Background Sickle cell disease (SCD) is a recessive hereditary condition. The physical changes caused by SCD affect the quality of life (QoL) by negatively impacting psychological aspects. Objective This study aimed to assess the prevalence of depression and anxiety in SCD patients based on different sociodemographic characteristics in Jeddah, Saudi Arabia. Method A cross-sectional study was conducted at King Abdulaziz University Hospital (KAUH) in Jeddah from 13 July to 30 August 2021. The included patients were 18 years of age and above and affected with sickle cell disease. Medical staff interviewed the patients and filled the Patient Health Questionnaire (PHQ)-9 and General Anxiety Disorder (GAD)-7. Result One hundred nineteen (119) patients were included in this study. The median age of participants was 32 and mostly male (n=72, 60.5%). The rate of depression was 45.4%. On the other hand, the rate of anxiety was 22.7%. The median of the PHQ-9 score was 8±8 while the median of the GAD-7 score was 5±8. Moreover, the study showed that anxiety and depression in relation to sociodemographics were higher in the patient age groups of 30-34 years old, male, single, unemployed, and with higher education. There was a significant association between depression rate and the two variables: patient employment status (49.3%; p=0.047) and a family history of SCD (51%). Conclusion Depression in patients with sickle cell disease is prevalent and correlated to demographic and social factors.

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“…Despite the significant differences in socioeconomic status between disease groups, poverty, education, and employment status were not associated with odds of mood disorders. Another study of adults with SCD also found that income and other socioeconomic factors did not have an impact on mental health 62 . More data confirming this finding are needed, but for Black Americans, future studies may find that chronic illness and related biological and psychosocial risk factors are greater contributors to mental health than socioeconomic factors.…”

Section: Discussionmentioning

confidence: 93%

Differences in the prevalence of mental health disorders among Black American adults with sickle cell disease compared to those with non‐heritable medical conditions or no medical conditions

et al. 2021

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Our aim was to determine differences in the prevalence of mental health disorders between Black Americans living with sickle cell disease (SCD) and Black Americans with other, non-heritable medical conditions, or no medical conditions. We examined the prevalence of mental health disorders among a non-institutionalized, community sample of Black adults in the US from the National Survey of American Life. We compared the odds of mental health disorders between Black American adults with SCD and those with other medical conditions, or no medical condition. Among the SCD group, 38Á8% reported at least one mental health disorder: 17Á6% endorsed a mood disorder, 24Á7% an anxiety disorder, 2Á4% an eating disorder, and 11Á8% a childhood disorder. Compared to those with other medical conditions, Black Americans with SCD had greater poverty, more children in the household, and were less likely to be married/cohabitating (all P < 0Á05). Yet, Black Americans with SCD were not at greater odds of having a mental health disorder compared to those with other medical conditions. When compared to the group with no conditions, however, individuals with SCD had 2Á57 greater odds of mood disorder (95% confidence interval: 1Á43-4Á65; P = 0Á002). The effect remained when controlling for socioeconomic status, marital status, and perceived physical health. In this study, almost 40% of Black American adults with SCD presented with a mental health disorder. Prevalence of mental health disorders was similar among those with non-heritable medical conditions, but those without a medical condition had a lower prevalence than in SCD. Among Black Americans, there appear to be unmeasured factors, common across medical conditions, that are linked to mental health disorders.

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Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)

Cited by 9 publications

References 29 publications

Trend of depression and its association with sociodemographic and clinical factors among multiple myeloma hospitalizations: A Portuguese nationwide study from 2000 to 2015

Trend of depression and its association with sociodemographic and clinical factors among multiple myeloma hospitalizations: A Portuguese nationwide study from 2000 to 2015

The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

Differences in the prevalence of mental health disorders among Black American adults with sickle cell disease compared to those with non‐heritable medical conditions or no medical conditions

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