Impact of Depressive Mood on Relapse in Patients With Inflammatory Bowel Disease: A Prospective 18-Month Follow-Up Study

Mittermaier, Christian; Dejaco, Clemens; Waldhoer, Thomas; Oefferlbauer-Ernst, Anna; Miehsler, Wolfgang; Beier, Markus; Tillinger, Wolfgang; Gangl, Alfred; Moser, Gabriele

doi:10.1097/01.psy.0000106907.24881.f2

Cited by 479 publications

(394 citation statements)

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“…It has previously been shown that depressed mood can impact negatively on the course of inflammatory bowel disorder (IBD) (Mittermaier et al 2004). Patients with IBD and co-morbid depression have been found to require higher doses of steroids than those with IBD alone (Szigethy et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression

et al. 2005

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Background. There is evidence to indicate that peripheral glucocorticoid receptor (GR) function is reduced in major depression, and a possible molecular explanation for this is the impact of raised pro-inflammatory cytokines. The topical steroid vasoconstriction assay provides a convenient probe of peripheral GR function. The present study sought to assess the sensitivity of peripheral GRs in antidepressant-resistant major depressives and investigate the association between GR sensitivity and circulating plasma cytokines.

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Section: Discussionmentioning

confidence: 99%

Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression

et al. 2005

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“…Depression, anxiety and stress are related to low QoL in IBD patients, which affects the frequency of relapses and thus course of IBD [15,37]. However, one study found that depression and anxiety at baseline were not related to number of relapses over a 12 month period in IBD patients compared to controls [38].…”

Section: Mood Disordersmentioning

confidence: 99%

“…Thus these guidelines include the recommendation of screening patients with IBD for mental disorders and distress, to offer appropriate psychosocial care when needed, and to communicate with mental health specialists during this process. Furthermore, many authors recommend the use of psychotherapy in IBD patients with mood disorders [13,23,37]. Including psychosocial factors in the treatment of pediatric patients with IBD has also been recommended [35,46].…”

Section: Psychological Interventionsmentioning

confidence: 99%

"Role of Psychosocial Factors on the Course of Inflammatory Bowel Disease and Associated Psychotherapeutic Approaches. A Fresh Perspective and Review"

Banan¹

2015

GHOA

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In this review article we seek to provide a fresh prospective on the role of psychosocial factors such as stress, anxiety, and depression, in the course of Inflammatory Bowel Diseases (IBD). IBD patients suffer from depression and anxiety at higher rates than the general population. Psychological stressors adversely affect the course of IBD through activation and possible dysfunction of the Brain-Gut-Axis. The mechanisms by which psychological factors increase mucosal inflammation, disrupt the intestinal barrier, and thereby worsen IBD symptoms are not well understood. This is a new and upcoming area of research that needs more attention because of its importance in managing and treating patients with IBD while also reducing costs associated with these disorders. Therefore, in this article we also seek to explore treatment options that target these psychological factors. Interventions include both pharmacological and nonpharmacological psychotherapeutic approaches. Whereas some of these therapies improve IBD symptoms, many also improve depression, anxiety, stress symptoms, fatigue, relapse rate, and Quality of Life (QOL) in both adults and children with IBD. These psychological factors are important determinants of health related quality of life (HRQOL) and therefore are important symptoms to treat alongside the IBD symptoms.

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“…심지어 증상이 완화되는 관해기 동안에도 재발에 대한 두려움으로 여전 히 삶의 활기나 활력이 저하되고 직장이나 사회생활에 어려움을 느끼고 있었다 (Graff, Walker, & Bernstein, 2009;Tanaka & Kazuma, 2005). 심리사회적 요인 중에는 우울 수준이 높을 때 삶의 질이 현저히 저하되었는데, 우울증상은 첫 발병 후부터 재발까지의 기간이 짧을 때 심했다 (Mittermaier et al, 2004). (Irvine, 2008).…”

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“…국외에서는 궤양성 대장염 환자의 우울이나 삶의 질을 파악 하고 (Lix et al, 2008;Mittermaier et al, 2004;Tanaka & Kazuma, 2005) 삶의 질에 영향을 미치는 요인을 다룬 연구 (Irvine, 2008;Van der Eijk et al, 2004) '심한 우울(severe depression)'로 분류하였다 (Beck et al, 1996). 도구의 신뢰도 Cronbach's ⍺값은 Kim 등 (2007) (Table 4).…”

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Factors related to Quality of Life of Patients with Ulcerative Colitis

Yoo

Chung

Cho

2014

Korean J Adult Nurs

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Purpose:The purpose of this study was to identify factors related to the quality of life of patients with ulcerative colitis. Methods: A total 116 patients with ulcerative colitis were asked on general characteristics, illness-related characteristics, depression, and quality of life. The collected data were analyzed by t-test, ANOVA, and stepwise multiple regression. Results: As for depression the 81.03% were normal, the 8.62% were mild depression, the 6.90% were moderated depression, and the 3.45% were severe. As for quality of life, the social functions was highest, followed by intestine-related symptoms, systemic symptoms, and emotional functions. Quality of life was positively correlated to subjective health status, age, and body mass index, and negatively to depression. Main factors affecting the quality of life included depression, subjective health status, physician's global assessment, age, days of loss in social life, and present abdominal pain. Conclusion: Physical and psychosocial health problems related to ulcerative colitis affected the quality of life of the patients. Further research is warranted for developing educational programs and psychosocial strategies in order to efficiently handle the illness. -64-754-3887, Fax: +82-64-702-2686, E-mail: ohcho@jejunu.ac.kr Received: Jul 11, 2013 / Revised: Mar 19, 2014 / Accepted: Mar 26, 2014 This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Impact of Depressive Mood on Relapse in Patients With Inflammatory Bowel Disease: A Prospective 18-Month Follow-Up Study

Abstract: Psychological factors such as a depressive mood associated with anxiety and impaired HRQOL may exert a negative influence on the course of IBD. Therefore, assessment and management of psychological distress should be included in clinical treatment of patients with IBD.

Cited by 479 publications

References 32 publications

Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression

Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression

"Role of Psychosocial Factors on the Course of Inflammatory Bowel Disease and Associated Psychotherapeutic Approaches. A Fresh Perspective and Review"

Factors related to Quality of Life of Patients with Ulcerative Colitis

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