Impact of Depressive Symptoms on All-Cause Mortality in Patients with Congestive Heart Failure After Cardiac Resynchronization Therapy

Pushkarev, G.; Кузнецов, В. А.; Fisher, Y A; Солдатова, А. М.; Sapozhnikova, Anna; Enina, T. N.

doi:10.18087/cardio.2019.1.10211

Cited by 9 publications

(2 citation statements)

References 25 publications

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“…A meta-analysis on the global prevalence of depression in adults with HF also found a higher prevalence of depression among women compared to men [ 12 ]. Females are more susceptible to stressors related to caregiving and family responsibilities, which could contribute to higher rates of depression [ 53 ]. Hormonal differences between men and women may also play a role in the development and severity of depression [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Comorbid depression among adults with heart failure in Ethiopia: a hospital-based cross-sectional study

Mulugeta,

Sinclair,

Wilson

2024

BMC Psychiatry

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Background Depression is a common comorbidity in adults with heart failure. It is associated with poor clinical outcomes, including decreased health-related quality of life and increased morbidity and mortality. There is a lack of data concerning the extent of this issue in Ethiopia. Consequently, this study aimed to assess the prevalence of comorbid depression and associated factors among adults living with heart failure in Ethiopia. Methods A hospital-based cross-sectional study was conducted at the cardiac outpatient clinics of two selected specialist public hospitals in Addis Ababa, Ethiopia: St. Paul’s Hospital Millennium Medical College and St. Peter Specialized Hospital. An interviewer-administered questionnaire was used to collect data from 383 adults with heart failure who attended the clinics and met the inclusion criteria. Depression was measured using the Patient Health Questionnaire (PHQ-9). A binary logistic regression model was fitted to identify factors associated with depression. All statistical analyses were conducted using STATA version 17 software. Results The mean age of the participants was 55 years. On average, participants had moderate depression, as indicated by the mean PHQ-9 score of 11.02 ± 6.14, and 217 (56.6%, 95%CI 51.53–61.68) had comorbid depression. Significant associations with depression were observed among participants who were female (AOR: 2.31, 95%CI:1.30–4.08), had comorbid diabetes mellitus (AOR: 3.16, 95%CI: 1.47–6.82), were classified as New York Heart Association (NYHA) class IV (AOR: 3.59, 95%CI: 1.05–12.30), reported poor levels of social support (AOR: 6.04, 95%CI: 2.97–12.32), and took more than five medications per day (AOR: 5.26, 95%CI: 2.72–10.18). Conclusions This study indicates that over half of all adults with heart failure in Ethiopia have comorbid depression, influenced by several factors. The findings have significant implications in terms of treatment outcomes and quality of life. More research in the area, including interventional and qualitative studies, and consideration of multifaceted approaches, such as psychosocial interventions, are needed to reduce the burden of comorbid depression in this population.

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Section: Discussionmentioning

confidence: 99%

Comorbid depression among adults with heart failure in Ethiopia: a hospital-based cross-sectional study

Mulugeta,

Sinclair,

Wilson

2024

BMC Psychiatry

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“…Доказано влияние депрессивной симптоматики на риск смерти у больных хронической сердечной недостаточностью. Как показало исследо-вание [15] (2019), в группе больных с выраженными депрессивными симптомами регистрировался более высокий относительный риск смерти (2,92), чем в группе больных без признаков депрессии (p=0,02). В другой работе [16] депрессия также ассоциировалась с повышенным риском смерти -ОШ=1,20 (95% ДИ: 1,11-1,28, р<0,001).…”

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Sex specificities of medical and social parameters in patients with coronary artery disease with different severity of depression

Нагибина

Kubareva

Князева

2021

Cardiovasc Ther Prev

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Aim. To determine the sex specificities of medical and social parameters in patients hospitalized due to coronary artery disease (CAD), class II, III, IV angina, aged 35-60 years and assess the significance of their relationship with different levels of depression.Material and methods. The study involved 312 patients aged 35-60 with documented CAD, class II, III, IV angina. Two comparison groups were identified: group I — 138 patients (men, 81; women, 57) with CAD and without depression (mean age, 47,8±4,6 years); group II — 174 patients (men, 60; women, 105) with CAD and depression (mean age, 48,3±5,3 years). Medical and social data, the severity of depression and distress tolerance, psychological status and quality of life was assessed. Statistical analysis was carried out, which are presented as the mean and standard error of the mean (M±m). The odds ratio (OR) and 95% confidence interval (CI) were calculated. Differences were considered significant at p<0,05.Results. The prevalence of depression among patients with CAD was 55,77%, while women were 1,5 times more likely to suffer it than men. Depression was significantly associated with hyperglycemia, hypercholesterolemia, and class III-IV angina, regardless of sex. Class III and IV angina prevailed in women, while class II angina — in men (OR, 2,16; 95% CI, 1,37-3,41, p<0,001)). Women were more prone to degree II-III disability (group II, 26,67%; group I 8,77%; p=0,008), compared with men (group II, 27,54%; group I, 11,11%; p=0,012). Sedentary lifestyle was also associated to a greater extent with the female sex than with the male (OR, 2,89, 95% CI, 1,46-5,70, p=0,003; OR, 2,31, 95% CI, 1,19-4,48; p=0,014, respectively). Both men and women showed a significant association of depression with atherosclerosis (p<0,001), however, sex differences did not reach significance. Indicators such as lack of job and higher education, as well as smoking and arrhythmias were characteristic of both sexes, but had a greater impact on the mental condition of men (p=0,002, p<0,001, p=0,0014 and p=0,01, respectively). For men, the relationship of depression with diabetes (8,7 vs 0%; p=0,008), obesity (42,03 vs 19,75%; p=0,004), subordinate status (82,61 vs 64,2%; p=0,016) and unmarried status (60,87 vs 40,74%; p=0,02).Conclusion. There are significant differences in factors contributing to depression in different sex groups. The association of depression with CAD has an adverse effect on the physical and psychological health of both males and females. At the same time, women are more prone to mental disorders than men. It is necessary to further study the sex characteristics of medical and social parameters in order to personalize treatment methods.

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Psychological state characteristics of patients with COVID-19-associated pneumonia in three months after hospital discharge

Guskova¹,

Yaroslavskaya²,

Prilensky³

et al. 2021

Profil. med.

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Impact of Depressive Symptoms on All-Cause Mortality in Patients with Congestive Heart Failure After Cardiac Resynchronization Therapy

Cited by 9 publications

References 25 publications

Comorbid depression among adults with heart failure in Ethiopia: a hospital-based cross-sectional study

Comorbid depression among adults with heart failure in Ethiopia: a hospital-based cross-sectional study

Sex specificities of medical and social parameters in patients with coronary artery disease with different severity of depression

Psychological state characteristics of patients with COVID-19-associated pneumonia in three months after hospital discharge

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