2022
DOI: 10.21203/rs.3.rs-1374844/v1
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Impact of Dexamethasone and Inhaled Nitric Oxide on Severe Acute Kidney Injury in Critically Ill Patients with COVID-19

Abstract: BackgroundKidney failure is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and is strongly associated with mortality. The aim of this multicentric study was to assess the impact of the specific treatments of COVID-19 and ARDS on the risk of severe acute kidney injury (AKI) in critically ill COVID-19 patients.MethodsIn this cohort study, data from consecutive patients hospitalized in 6 ICUs for COVID-19 were retrospectively col… Show more

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Cited by 3 publications
(2 citation statements)
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“…A multicenter cohort study included in this study showed that moderateto-severe ARDS in critically ill patients of COVID-19 who received inhaled NO illustrated significantly higher odds of AKI (Al Sulaiman et al, 2022). A latest study on SAEs of NO showed that inhaled NO was associated with severe AKI and renal replacement therapy in critically ill patients of COVID-19 (Bobot et al, 2022). During the pandemic, some researchers tried to use NO for pregnant women with severe to critical COVID-19, and no acute adverse events related to NO were observed (Safaee Fakhr et al, 2020;Valsecchi et al, 2022).…”
Section: Figurementioning
confidence: 80%
“…A multicenter cohort study included in this study showed that moderateto-severe ARDS in critically ill patients of COVID-19 who received inhaled NO illustrated significantly higher odds of AKI (Al Sulaiman et al, 2022). A latest study on SAEs of NO showed that inhaled NO was associated with severe AKI and renal replacement therapy in critically ill patients of COVID-19 (Bobot et al, 2022). During the pandemic, some researchers tried to use NO for pregnant women with severe to critical COVID-19, and no acute adverse events related to NO were observed (Safaee Fakhr et al, 2020;Valsecchi et al, 2022).…”
Section: Figurementioning
confidence: 80%
“…Corticosteroids are mainly used, however, there are a number of studies that suggest that early use of high-dose corticosteroids can increase the death of ALI/ARDS patients, so the use is not recommended (Mokra et al, 2019;Bobot et al, 2022).…”
Section: Anti-inflammatory Drugsmentioning
confidence: 99%