Impact of diabetes mellitus and metabolic control on bone healing around osseointegrated implants: removal torque and histomorphometric analysis in rats

Molon, Rafael Scaf de; Morais-Camilo, Juliana Aparecida Najarro Dearo; Verzola, Mário Henrique Arruda; Faeda, Rafael Silveira; Pepato, Maria Teresa; Marcantonio, Élcio

doi:10.1111/j.1600-0501.2012.02467.x

Cited by 74 publications

(67 citation statements)

References 35 publications

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“…We found that the diabetic state in animals determined a significant delay in the bone formation process throughout the trial period, as previously demonstrated in other studies 18 .…”

Section: Discussionsupporting

confidence: 91%

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Nascimento

Almeida

Cunha³

et al. 2015

Acta Cir. Bras.

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Brazil. Design of the study, histological examinations, manuscript writing, supervised all phases of the study. ABSTRACT PURPOSE:To investigate the effect of low-level laser therapy on bone healing in diabetic rats. METHODS:Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed. RESULTS:Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p<0.001), and improved bone healing at seven (p<0.01), 18 (p<0.05) and 30 (p<0.01) in diabetic animals. In addition, bone healing in irradiated diabetic group was statistically similar to control group at 30 days (p>0.05). CONCLUSION:Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxaninduced diabetic rats.

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“…We found that the diabetic state in animals determined a significant delay in the bone formation process throughout the trial period, as previously demonstrated in other studies 18 .…”

Section: Discussionsupporting

confidence: 91%

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Nascimento

Almeida

Cunha³

et al. 2015

Acta Cir. Bras.

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“…The findings of the present observational study concur with those of several earlier studies, which demonstrated that hyperglycemic state leads to alterations in bone functions. 18,19,20,21 Other retrospective studies have also recognized pathological changes in bone function related to chronic hyperglycemia. 22,23 The present study observed that PIBL was high in T2DM patients in relation to mean HbA1c levels of 8.2%.…”

Section: Discussionmentioning

confidence: 99%

Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up

Zahrani

Mutairi

2018

Braz. oral res.

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Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up Abstract: To evaluate peri-implant bone loss (PIBL) and stability around submerged and non-submerged dental implants in patients with and without type 2 diabetes mellitus (T2DM). Thirty-five T2DM and non-diabetic (NT2DM) patients were included in this study. Demographic data were recorded using a questionnaire and PIBL was measured on digital radiographs. Resonance frequency analysis (RFA) was carried out for each implant at the time of fixture placement and at 3 months in both groups. P values less than 0.05 were considered statistically significant. One hundred and eighteen dental implants with a mean height of 10 to 12 mm and 3.3 to 4.1 mm in diameter were placed. The comparison of the mean RFA values at baseline and at 3 months was statistically significant (p = 0.008) in T2DM patients. The inter-group mean RFA values at baseline and at 3 months were not significant (p > 0.05). PIBL was significantly high in T2DM as compared to NT2DM patients at each follow-up (p < 0.05). At 2, 3, and 7 years, non-submerged dental implants showed significantly high PIBL in T2DM patients as compared to NT2DM individuals (p<0.05). The results of the present clinical study demonstrate increased PIBL around non-submerged single-tooth implant-supported restorations in T2DM patients, which may be due to the immune inflammatory status.

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“…On the contrary, sequester was not formed throughout the whole period, although the alveolar crest was in close proximity with ulcer surface at the early phase. Sequester of Group DM was heavily infected with bacterial colonies, and consequently could hardly be resorbed and isolated by surrounding inflamed granulation tissue, bringing persistent inflammation, and impaired healing 12,47,48) . Subsequently experiment 2 was carried out to examine the relation between sequester formation and large amount of bacterial deposition, where the effect of disinfection to the gingival col was challenged.…”

Section: The Measurement Of Osteoclastsmentioning

confidence: 99%

Disturbance of Periodontal Tissue Caused by Mechanical Compression into the Gingival Col of Streptozotocin-induced Diabetic Rats

Tokunaga

Enoki

Okamura

et al. 2014

J. Hard Tissue Biology.

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FThe purpose of this study is to clarify the destructive processes of periodontal tissue, especially of alveolar bone, induced by food impaction. Streptozotocin-induced diabetic rat was used, gutter percha point (GP) was inserted into interdental gingival col space between upper M1 and M2, and the change of body weight, histopathological findings and 3D SEM structure of alveolar bone were compared between diabetic (Group DM) and control (Group N) animals (Experiment 1). Large amounts of bacterial deposits and sequester were observed at the alveolar crest, and subsequently experiment 2 was carried out to explore the relationship between bacterial infection and sequester formation. The combination of mechanical compression and daily twice cleaning with 3% oxydol and Periocline were carried out. As a result of experiment 1, ulceration with partial exposure of alveolar crest, inflammatory infiltrates and hyaline degeneration occurred in the col, and bone resorption was scarcely observed at 1d in Group N. Bone resorption of alveolar bone progressed at 3d and 5d, decreasing the height of alveolar crest and the width of alveolar bone. Reepithelization of ulcer surface was observed at 7d and 14d, and concurrently bone resorption regressed and new bone formation suggested reparative changes. SEM observation confirmed these changes of alveolar bone. On the contrary, massive bacterial deposits were observed, and bone resorption was scanty in the upper region and slight in the middle to lower region of alveolar bone at 1 day of Group DM. Massive bacterial deposits with partial exposure of alveolar bone were observed at 3d and 5d, and sequester was isolated owing to intense undermining bone resorption. Regeneration of epithelium was seen beneath the sequester at 14d, showing the phenomenon of foreign body exclusion. The light microscopic changes of Group DM were consistent with SEM findings. The total number of osteoclasts was fewer at 1d and larger at 3d and 5d in Group DM. Osteoclasts at the upper region of alveolar bone increased from 1d to 5d in Group N, although the number of osteoclasts did not show a significant change in Group DM. At the middle to lower portion of alveolar bone, the number of osteoclast was significantly fewer at 1d, larger at 3d and 5d in Group DM. In experiment 2, the col with ulceration and necrosis did not show bacterial deposits or sequester, suggesting the intimate relation between bacterial infection and sequestration. The present study suggests that food impaction and subsequent mechanical compression to the col could induce various damages of periodontal tissue, including sequester formation, and elaborate plaque control at the initial stage of food impaction could prevent sequester formation and protect the height of alveolar bone.

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Impact of diabetes mellitus and metabolic control on bone healing around osseointegrated implants: removal torque and histomorphometric analysis in rats

Cited by 74 publications

References 35 publications

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up

Disturbance of Periodontal Tissue Caused by Mechanical Compression into the Gingival Col of Streptozotocin-induced Diabetic Rats

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