Impact of diabetes mellitus on long-term follow-up of percutaneous coronary intervention based on clinical presentation of coronary artery disease

Ruperto, Cettina; Capodanno, Davide; Blundo, Anita; Capranzano, Piera; Sanfilippo, Alessandra; Caggegi, Anna; Bucalo, Rita; Giaimo, Valerio; Tamburino, Corrado

doi:10.2459/jcm.0b013e3283448695

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…In our study, the relatively high prevalence of diabetes in AMI patients (27.4%) is within the previously reported range of 14% to 34% (18, 24, 28). The diabetic patients also had more traditional risk factors, such as high BMI, hypertension, dyslipidemia and previous history of ischemic heart disease (24, 29).…”

Section: Discussionsupporting

confidence: 91%

Differential Prognostic Impacts of Diabetes over Time Course after Acute Myocardial Infarction

et al. 2013

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This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 patients (27.4%) had diabetes. Short-term MACEs, which occurred within 30 days of AMI onset, were observed in 1,364 patients (6.1%). Among the 30-day survivors (n = 21,604), mid-term MACEs, which occurred between 31 and 365 days after AMI onset, were observed in 1,181 patients (5.4%). After adjustment for potential confounders, diabetes was an independent predictor of mid-term MACEs (HR, 1.25; 95% CI, 1.08-1.45; P = 0.002), but not of short-term MACEs (HR: 1.16; 95% CI: 0.93-1.44; P = 0.167). Diabetes is a poor prognostic factor for mid-term clinical outcomes but not for short-term outcomes in AMI patients. Careful monitoring and intensive care should be considered in diabetic patients, especially following the acute stage of AMI.

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Section: Discussionsupporting

confidence: 91%

Differential Prognostic Impacts of Diabetes over Time Course after Acute Myocardial Infarction

et al. 2013

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“…Eleven studies [7,8,11,14,16–18,20,26,28,33] as well as our data reported TVR; the pooled analysis showed that DM patients had a higher incidence of TVR (RR = 1.40, 95% CI 1.24–1.59, I 2 = 43%) (Fig. 2).…”

Section: Resultssupporting

confidence: 59%

“…[ 12 , 13 ] However, compared with non-DM patients, DM patients still have a high risk of major adverse cardiac events (MACEs) with DES. [ 14 – 16 ] Some studies found that the incidence of cardiac death between patients with or without DM is similar. [ 17 ] But some other large sample clinical trials found that patients with DM still had a higher risk of MACE even with DES.…”

Section: Introductionmentioning

confidence: 99%

Comparison of clinical outcomes after drug-eluting stent implantation in diabetic versus nondiabetic patients in China

et al. 2017

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Diabetes mellitus (DM) has been proved to be a predictor of adverse outcomes after percutaneous coronary intervention (PCI). Drug-eluting stents (DESs) could reduce the adverse events in DM patients. In this study, we aimed to analyze the clinical outcome after DES implantation in diabetic versus nondiabetic patients in China. Totally, 200 Chinese DM patients and 400 Chinese non-DM patients were enrolled in this retrospective study. Compared with non-DM patients, DM patients were more likely to have a higher incidence of cardiac death (3.5% vs. 1.0%, P = .048), stent thrombosis (2.5% vs. 0.5%, P = .044), target lesion revascularization (6.0% vs. 1.8%, P = .005), target vessel failure (15.5% vs. 8.0%, P < .001), target lesion failure (14.0% vs. 4.3%, P < .001), myocardial infarction (4.5% vs. 1.5%, P = .030), and major adverse cardiac events (12.5% vs. 5.0%, P = .001) at 2-year follow-up. However, the incidence of target vessel revascularization (7.5% vs. 5.5%, P = .340) was similar between DB and non-DB patients. Patients with DB (hazard ratio [HR] = 2.54, P = .001), older than 80 years (HR = 1.33, P = .027) with hypercholesterolemia (HR = 1.03, P < .001), serum creatinine >177 μmol/L (HR = 3.04, P = .011), a history of cerebral vascular accident (HR = 4.29, P = .010), or a history of myocardial infarction (HR = 31.4, P < .001) were more likely to experience adverse events. In China, DM could also be served as an independent predictor of adverse outcomes after DES implantation. These patients should be reexamined more frequently.

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“…In conclusion, concerns arose in the planning of the study by Ruperto et al 1 There is a lack of data on the prognostic importance of silent ischemia in totally asymptomatic patients and, particularly, on a possible benefit of medical and interventional therapy in such patients.…”

mentioning

confidence: 93%

“…The retrospective study by Ruperto et al 1 investigates the influence of clinical presentation on 3-year follow-up of patients with and without diabetes who had undergone a percutaneous coronary intervention (PCI) with drugeluting stent (DES) implantation. The study concludes that it demonstrates that diabetes mellitus patients have a worse prognosis, not depending on their clinical presentation which could be acute coronary syndrome (ACS) or stable angina.…”

mentioning

confidence: 99%

No significant interaction between diabetes and clinical presentation in the outcome of percutaneous coronary intervention

Agushi¹

2011

Journal of Cardiovascular Medicine

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Impact of diabetes mellitus on long-term follow-up of percutaneous coronary intervention based on clinical presentation of coronary artery disease

Cited by 9 publications

References 30 publications

Differential Prognostic Impacts of Diabetes over Time Course after Acute Myocardial Infarction

Differential Prognostic Impacts of Diabetes over Time Course after Acute Myocardial Infarction

Comparison of clinical outcomes after drug-eluting stent implantation in diabetic versus nondiabetic patients in China

No significant interaction between diabetes and clinical presentation in the outcome of percutaneous coronary intervention

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