Impact of diabetes on cancer chemotherapy outcome: A retrospective analysis

Attili, Venkata Satya Suresh; Bapsy, P P; Dadhich, HemantK; Batra, U.; Lokanatha, D.; Babu, K Govind

doi:10.4103/0973-3930.38631

Cited by 10 publications

(14 citation statements)

References 20 publications

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“…The majority of the literature exploring the relationship between diabetes and cancer focuses on complications or health-related outcomes associated with cancer and its treatment. 3,4,6…”

Section: Literature Reviewmentioning

confidence: 99%

“…The majority of the literature exploring the relationship between diabetes and cancer focuses on complications or health-related outcomes associated with cancer and its treatment. 3,4,6 Diabetes is associated with an increase in mortality and poor response rates to treatment. 2,3,5,47 In a literature review, Psarakis 47 noted that individuals with diabetes and cancer have a poorer prognosis, higher infection rates, and shorter remission periods than those without diabetes.…”

Section: Cancer and Diabetesmentioning

confidence: 99%

“…Hyperglycemia in diabetes was noted to be one of the factors associated with these poorer outcomes. Attili 6 noted that individuals with cancer and diabetes with good glycemic control are at equal risk for treatment-related complications when compared with individuals without diabetes.…”

Section: Cancer and Diabetesmentioning

confidence: 99%

“…It has been hypothesized that glycemic levels may play a role in the development of complications for individuals with diabetes who are undergoing chemotherapy. 6 Self-management behaviors for diabetes can have a positive impact on glycemic control. [7][8][9] Individuals who perform fewer self-management activities for their diabetes have poorer glycemic control.…”

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confidence: 99%

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Perceived Impact of Cancer Treatment on Diabetes Self-Management

et al. 2012

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Cancer treatment and cancer-related symptoms can have a negative impact on diabetes self-management behaviors in adults with diabetes who are undergoing chemotherapy. Diabetes self-management education is targeted to improve health outcomes in patients with diabetes and cancer and addresses the "cause" not just the "source" of the problem needs to be developed. Further research needs to be done to address issues related to glycemic control and health-related outcomes in this population.

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“…The majority of the literature exploring the relationship between diabetes and cancer focuses on complications or health-related outcomes associated with cancer and its treatment. 3,4,6…”

Section: Literature Reviewmentioning

confidence: 99%

Section: Cancer and Diabetesmentioning

confidence: 99%

Section: Cancer and Diabetesmentioning

confidence: 99%

mentioning

confidence: 99%

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Perceived Impact of Cancer Treatment on Diabetes Self-Management

et al. 2012

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“…17 One retrospective series failed to identify a correlation between diabetes and increased toxicity from chemotherapy, assessed through the Common Toxicity Criteria for Adverse Events, although, as the same authors suggest, this could have been related to the good glycemic control in the diabetic group of patients, beside the small sample size (N ϭ 119). 18 On the basis of these findings, we designed a retrospective analysis to study the correlation of glycemia with the outcomes of patients undergoing chemotherapy regimens, which frequently lead to hyperglycemia.…”

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confidence: 99%

Hyperglycemia During Chemotherapy for Hematologic and Solid Tumors Is Correlated With Increased Toxicity

Brunello¹,

Kapoor²,

Extermann³

2011

American Journal of Clinical Oncology

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Chemo‐mechanistic multi‐scale model of a three‐dimensional tumor microenvironment to quantify the chemotherapy response of cancer

Nikmaneshi

Firoozabadi

Mozafari

2021

Biotech & Bioengineering

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Exploring efficient chemotherapy would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. As in vivo experimental methods are unable to isolate or control individual factors of the TME, and in vitro models often cannot include all the contributing factors, some questions are best addressed with mathematical models of systems biology. In this study, we establish a multi‐scale mathematical model of the TME to simulate three‐dimensional tumor growth and angiogenesis and then implement the model for an array of chemotherapy approaches to elucidate the effect of TME conditions and drug scheduling on controlling tumor progression. The hyperglycemic condition as the most common disorder for cancer patients is considered to evaluate its impact on cancer response to chemotherapy. We show that combining antiangiogenic and anticancer drugs improves the outcome of treatment and can decrease accumulation of the drug in normal tissue and enhance drug delivery to the tumor. Our results demonstrate that although both concurrent and neoadjuvant combination therapies can increase intratumoral drug exposure and therapeutic accuracy, neoadjuvant therapy surpasses this, especially against hyperglycemia. Our model provides mechanistic explanations for clinical observations of tumor progression and response to treatment and establishes a computational framework for exploring better treatment strategies.

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Impact of diabetes on cancer chemotherapy outcome: A retrospective analysis

Cited by 10 publications

References 20 publications

Perceived Impact of Cancer Treatment on Diabetes Self-Management

Perceived Impact of Cancer Treatment on Diabetes Self-Management

Hyperglycemia During Chemotherapy for Hematologic and Solid Tumors Is Correlated With Increased Toxicity

Chemo‐mechanistic multi‐scale model of a three‐dimensional tumor microenvironment to quantify the chemotherapy response of cancer

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