Impact of Diabetes on Five-Year Outcomes of Patients With Multivessel Coronary Artery Disease

Hueb, Whady; Gersh, Bernard J.; Costa, Fernando Ferreira; Lopes, Neuza; Soares, Paulo Rogério; Dutra, Paulo; Jatene, Fábio Biscegli; Pereira, Alexandre C.; Gois, Aecio F; Oliveira, Sérgio Almeida de; Ramires, José Antônio Franchini

doi:10.1016/j.athoracsur.2006.08.050

Cited by 46 publications

(44 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13,14,31 Although a number of factors are likely to contribute to impaired angiogenesis in diabetes, the results of our study are the first to describe alterations in the VEGFR-ligand system as a potential contributor to this process. We and others found that mice with DM have Figure 4.…”

Section: Discussionmentioning

confidence: 93%

“…12 In patients with cardiovascular disease, a defective angiogenic response to ischemia could, in part, account for poor clinical outcomes. 13,14 In preclinical models of peripheral arterial disease (PAD), diabetic animals have been shown to have attenuated perfusion recovery in response to ischemia. 15,16 Studies that have investigated the causes of the reduced angiogenic response in diabetes have focused on an impaired release of endothelial progenitor cells from the bone marrow, 17 defective function of progenitor cells, 17,18 or formation of advanced glycosylation end products.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Impaired Angiogenesis After Hindlimb Ischemia in Type 2 Diabetes Mellitus

Hazarika

Dokun

et al. 2007

Circulation Research

181

103

View full text Add to dashboard Cite

Abstract-Deficient angiogenesis after ischemia may contribute to worse outcomes of peripheral arterial disease in patients with diabetes mellitus (DM). Vascular endothelial growth factor (VEGF) and its receptors promote angiogenesis. We hypothesized that in peripheral arterial disease, maladaptive changes in VEGF ligand/receptor expression could account for impaired angiogenesis in DM. Skeletal muscle from diet-induced, type 2 diabetic (DM) and age-matched normal chow (NC)-fed mice was collected at baseline and 3 and 10 days after hindlimb ischemia and analyzed for expression of VEGF (nϭ10 per

show abstract

Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 99%

Impaired Angiogenesis After Hindlimb Ischemia in Type 2 Diabetes Mellitus

Hazarika

Dokun

et al. 2007

Circulation Research

181

103

View full text Add to dashboard Cite

show abstract

“…Recently, published data suggested that the avoidance of aortic manipulation is the most important factor in reducing the risk of neurological complications. 84,85 Patients with extensive disease of the ascending aorta pose a special challenge for on-pump CABG; for these patients, cannulation or cross-clamping of the aorta may create an unacceptably high risk of stroke. In such individuals, off-pump CABG in conjunction with avoidance of manipulation of the ascending aorta (including placement of proximal anastomoses) may be beneficial.…”

Section: Off-pump Cabg Versus Traditional On-pump Cabgmentioning

confidence: 99%

2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery

et al. 2011

View full text Add to dashboard Cite

“…The use of statins has been shown to be associated with lower risk of postoperative stroke both in early 35 and late follow-up. 36 Dual antiplatelet therapy is also not routine after CABG. 10 This can again contribute to late strokes in patients undergoing CABG.…”

Section: Discussionmentioning

confidence: 99%

Late Stroke: Comparison of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Multivessel Disease and Unprotected Left Main Disease

Athappan

Chacko

Patvardhan

et al. 2014

Stroke

View full text Add to dashboard Cite

Background and Purpose-Studies have suggested that the early excess risk of stroke in coronary artery bypass grafting (CABG) may be compensated for by a slow but progressive catch-up phenomenon in patients undergoing percutaneous coronary intervention (PCI). We therefore undertook this analysis to compare the temporal stroke risk between PCI and CABG in patients with unprotected left main stenosis and multivessel coronary artery disease. Methods-Studies of PCI versus CABG for unprotected left main stenosis and multivessel disease published between January 1994 (stent era) and July 2013 were identified using an electronic search and reviewed using meta-analytic techniques. Results-We selected 57 reports for the meta-analysis by applying the inclusion and exclusion criteria. The primary search terms used were CABG and PCI. For the Cochrane database the search terms were limited by the term clinical trial. Limiting the search parameters to the English language was applied subsequently. Citations were screened at the title and abstract level and retrieved as full reports if they were clinical studies, compared PCI with CABG, and provided information on the outcome of stroke. The full texts of all potential articles were reviewed in detail. The bibliography of retained studies was used to seek additional relevant studies. Inclusion CriteriaStudies were included if the following criteria applied: (1) comparative trials of CABG versus PCI with stent placement, (2) unprotected left main stenosis of >50% narrowing or multivessel disease, (3) a minimum of 30 patients, and (4) a minimum follow-up of 1 year. When 2 similar studies were reported from the same institution or author, the most recent publication was included in the analysis. Exclusion CriteriaStudies were excluded if any of the following criteria applied: (1) outcome of interest was not clearly reported or was impossible to extract or calculate from the published results, (2) <1-year follow-up, (3) included patients with ST-segment-elevation myocardial infarction, and (4) included patients with percutaneous transluminal coronary angioplasty without stents. Data ExtractionInformation collected included first author, year and journal of publication, study design, inclusion/exclusion criteria, definition of primary and secondary end points, number of subjects included, subjects undergoing PCI and CABG, percentage of drug-eluting stent used, study population demographics, number of diseased vessels, stenting technique, type of CABG (on pump versus off pump), left internal mammary artery graft used (single versus double), follow-up time period, rates of angiographic follow-up, antiplatelet regimen used, and primary and secondary outcomes. There was no disagreement between the 2 reviewers (G.A. and P.C.).

show abstract

Impact of Diabetes on Five-Year Outcomes of Patients With Multivessel Coronary Artery Disease

Cited by 46 publications

References 8 publications

Impaired Angiogenesis After Hindlimb Ischemia in Type 2 Diabetes Mellitus

Impaired Angiogenesis After Hindlimb Ischemia in Type 2 Diabetes Mellitus

2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery

Late Stroke: Comparison of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Multivessel Disease and Unprotected Left Main Disease

Contact Info

Product

Resources

About