Impact of diabetes on muscle mass, muscle strength, and exercise tolerance in patients after coronary artery bypass grafting

Nishitani, Miho; Shimada, Kazunori; Sunayama, Satoshi; Masaki, Yoshiyuki; Kume, Atsumi; Fujita, Kosuke; Sai, Eiryu; Yamashita, Haruyo; Ohmura, Hirotoshi; Onishi, Tomo; Shioya, Miki; Sato, Hiroyuki; Shimada, Akira; Yamamoto, Taira; Amano, Atsushi; Daida, Hiroyuki

doi:10.1016/j.jjcc.2011.05.001

Cited by 37 publications

(28 citation statements)

References 24 publications

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“…However, why the baseline use of insulin therapy predicted IADL impairment is unclear. It seems likely that the muscle strength might be lower in patients receiving insulin treatment, or that the administration of insulin therapy might affect the quality of life of the aged patients, which might cause difficulties in maintaining their instrumental independence, intellectual activity and normal social roles 40 …”

Section: Discussionmentioning

confidence: 99%

Risk factors for a 6‐year decline in physical disability and functional limitations among elderly people with type 2 diabetes in the Japanese elderly diabetes intervention trial

Sakurai

Iimuro

Sakamaki

et al. 2012

Geriatrics Gerontology Int

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Aim: Type 2 diabetes increases the risk of disability. The purpose of this study was to clarify the explanatory factors for disability in Japanese diabetic elderly. Methods:The 6-year decline in physical disability and functional limitations was investigated among 317 elderly people with type 2 diabetes recruited in a large-scale prospective study of the Japanese Elderly Diabetes Intervention Trial. Information about diabetes, blood examinations and complications was obtained, and basic activities of daily living (ADL) and instrumental ADL (IADL) were assessed by total score of the Barthel index and the Tokyo Metropolitan Institute of Gerontology Index of Competence, respectively.Results: After 6 years of follow up, 13.6% of patients had developed a new ADL disability and 38.3% had developed a new functional impairment. In the 65-74 years age group, basic ADL decreased only in males, whereas females became functionally impaired. In the 75-84 years age group, basic and IADL decreased in both males and females. Older age and metabolic syndrome were prognostic for impairment of basic ADL, whereas baseline IADL problems, lower cognitive function, physical inactivity and insulin therapy were significant predictors of a future decline in the IADL. Conclusion:This study identified several factors predicting the future decline of basic ADL and IADL in diabetic elderly patients, and provided a conceptual framework that might help to clarify the pathways leading to disability. Because the specific causes of each

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Section: Discussionmentioning

confidence: 99%

Risk factors for a 6‐year decline in physical disability and functional limitations among elderly people with type 2 diabetes in the Japanese elderly diabetes intervention trial

Sakurai

Iimuro

Sakamaki

et al. 2012

Geriatrics Gerontology Int

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“…Briefly, after the screening session, all participants visited our institute three times for baseline evaluation. At the first or second visit, each participant underwent OGTT or peak oxygen uptake test as described previously 10, 35 . The participants were instructed to quit regular exercise for 10 days before the third visit and the mean daily physical activity level was evaluated over 7 days with an accelerometer (Lifecorder; Suzuken, Nagoya, Japan).…”

Section: Methodsmentioning

confidence: 99%

Correlates of insulin clearance in apparently healthy non-obese Japanese men

Tamura

Takeno

Kakehi

et al. 2017

Sci Rep

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Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI <25 kg/m2), we studied 49 non-obese Japanese men free of cardiometabolic risk factors. Using a 2-step hyperinsulinemic euglycemic clamp, we evaluated MCRI and insulin sensitivity. We also calculated the rate of glucose disappearance (Rd) during the clamp and muscle insulin sensitivity was defined as Rd/steady state serum insulin (SSSI) at the second step. Based on the median value of MCRI, the subjects were divided into the low- and high-MCRI groups. Subjects of the low-MCRI group had significant impairment of muscle insulin sensitivity, although Rd levels were comparable between the two groups, probably due to elevated SSSI in the low-MCRI group. Subjects of the low-MCRI group had higher total body fat content and lower VO2peak and showed no deterioration of cardiometabolic risk factors. Our results suggest that low MCRI may be early change to maintain glucose uptake and metabolic status in the face of slight impairment of muscle insulin sensitivity caused by increased adiposity and lower fitness level.

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“…After a 3-min rest period, a warm-up was performed for 3 minutes at 40 W, followed by ramp loading (15–30 W/min) until the subjective exhaustion, as described previously [22]. According to the ATS/ACCP guidelines, AT was determined by V-slope method.…”

Section: Methodsmentioning

confidence: 99%

Association between Myocardial Triglyceride Content and Cardiac Function in Healthy Subjects and Endurance Athletes

et al. 2013

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Ectopic fat accumulation plays important roles in various metabolic disorders and cardiovascular diseases. Recent studies reported that myocardial triglyceride (TG) content measured by proton magnetic resonance spectroscopy (1H-MRS) is associated with aging, diabetes mellitus, and cardiac dysfunction. However, myocardial TG content in athletes has not yet been investigated. We performed 1H-MRS and cardiac magnetic resonance imaging in 10 male endurance athletes and 15 healthy male controls. Serum markers and other clinical parameters including arterial stiffness were measured. Cardiopulmonary exercise testing was also performed. There were no significant differences in clinical characteristics including age, anthropometric parameters, blood test results, or arterial stiffness between the two groups. Peak oxygen uptakes, end–diastolic volume (EDV), end–systolic volume (ESV), left ventricular (LV) mass, peak ejection rates and peak filling rates were significantly higher in the athlete group than in the control group (all P<0.02). Myocardial TG content was significantly lower in the athlete group than in the control group (0.60±0.20 vs. 0.89±0.41%, P<0.05). Myocardial TG content was negatively correlated with EDV (r = −0.47), ESV (r = −0.64), LV mass (r = −0.44), and epicardial fat volume (r = 0.47) (all P<0.05). In conclusion, lower levels of myocardial TG content were observed in endurance athletes and were associated with morphological changes related to physiological LV alteration in athletes, suggesting that metabolic imaging for measurement of myocardial TG content by 1H-MRS may be a useful technique for noninvasively assessing the “athlete’s heart”.

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Impact of diabetes on muscle mass, muscle strength, and exercise tolerance in patients after coronary artery bypass grafting

Cited by 37 publications

References 24 publications

Risk factors for a 6‐year decline in physical disability and functional limitations among elderly people with type 2 diabetes in the Japanese elderly diabetes intervention trial

Risk factors for a 6‐year decline in physical disability and functional limitations among elderly people with type 2 diabetes in the Japanese elderly diabetes intervention trial

Correlates of insulin clearance in apparently healthy non-obese Japanese men

Association between Myocardial Triglyceride Content and Cardiac Function in Healthy Subjects and Endurance Athletes

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