Impact of Diabetes on the Recurrence and Prognosis of Acute Kidney Injury in Older Male Patients: A 10-Year Retrospective Cohort Study

Shen, Xipeng; Lv, Kunming; Hou, Baicun; Ao, Qiangguo; Zhao, Jiahui; Yang, Guang

doi:10.1007/s13300-022-01309-w

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…There have been 2 retrospective analyses, both of which had conflicting findings. [10,57] Diabetic patients had less severe AKI, recovery to baseline renal function and the proportion of patients developing progressive CKD was lower in the diabetic group as shown by Johns et al [10] However, the 10-year retrospective analysis done by Xin S et al showed that the recurrence rate of AKI was higher in the diabetic group than in the nondiabetic group. [57] Between diabetes and nondiabetic groups, mortality was comparable in both retrospective analyses.…”

Section: Aki In Diabetic Versus Nondiabetic Patientsmentioning

confidence: 99%

Acute kidney injury in diabetic patients: A narrative review

Kaur

Sharma

Kumbala³

2023

Medicine

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Diabetes mellitus (DM) is the most common cause of chronic kidney disease, which leads to end-stage renal failure worldwide. Glomerular damage, renal arteriosclerosis, and atherosclerosis are the contributing factors in diabetic patients, leading to the progression of kidney damage. Diabetes is a distinct risk factor for acute kidney injury (AKI) and AKI is associated with faster advancement of renal disease in patients with diabetes. The long-term consequences of AKI include the development of end-stage renal disease, higher cardiovascular and cerebral events, poor quality of life, and high morbidity and mortality. In general, not many studies discussed extensively “AKI in DM.” Moreover, articles addressing this topic are scarce. It is also important to know the cause of AKI in diabetic patients so that timely intervention and preventive strategies can be implemented to decrease kidney injury. Aim of this review article is to address the epidemiology of AKI, its risk factors, different pathophysiological mechanisms, how AKI differs between diabetic and nondiabetic patients and its preventive and therapeutic implications in diabetics. The increasing occurrence and prevalence of AKI and DM, as well as other pertinent issues, motivated us to address this topic.

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Section: Aki In Diabetic Versus Nondiabetic Patientsmentioning

confidence: 99%

Acute kidney injury in diabetic patients: A narrative review

Kaur

Sharma

Kumbala³

2023

Medicine

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“…Diabetes is a global public health concern that is associated with high morbidity. [ 1 ] The incidence of diabetes has been rapidly increasing in China, and has the highest prevalence of approximately 12% in people aged 70 to 80 years. [ 2 , 3 ] The pathophysiological changes associated with diabetes in elderly patients include abnormal insulin secretion or defective insulin action, mainly characterized by chronically elevated glucose levels and extended disease duration.…”

Section: Introductionmentioning

confidence: 99%

Value of Hcy combined with Framingham score for predicting macrovascular disease in elderly patients with type 2 diabetes

Wang,

Liu

2023

Medicine

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To analyze the predictive value of homocysteine (Hcy) combined with the Framingham risk score for cardio- and cerebrovascular disease in elderly patients with type 2 diabetes mellitus (T2DM) to provide a reference for clinical treatment. We retrospectively reviewed the clinical data of 1036 elderly patients with T2DM admitted to our hospital between July 2017 and July 2022. The patients were divided into occurrence (n = 438) and control (n = 598) groups based on the incidence of cardio- or cerebrovascular disease. Univariate and multivariate logistic analyses were used to analyze the factors associated with cardio-cerebral small-vessel disease in the elderly patients with T2DM. The predictive value of Hcy combined with the Framingham score for cardio- and cerebrovascular diseases in elderly patients with T2DM was determined using receiver operating characteristic curves. Univariate analysis showed that the occurrence group had significantly higher Framingham score, systolic blood pressure (SBP), total cholesterol (TC), fasting blood glucose (FBG), 2-hour postprandial plasma glucose, Hcy, glycated hemoglobin, smoking history, and disease duration than the control group (all P < .05). Food preferences, sleep duration, physical exercise, high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were significantly lower in the occurrence group than in the control group (all P < .05). Multivariate logistic analysis showed that smoking history, duration of diabetes, Framingham score, SBP, TC, FBG, HDL-C, 2h postprandial plasma glucose, and Hcy levels were risk factors for cardio- and cerebrovascular disease in elderly patients with T2DM. The area under the curve for Hcy and Framingham scores was 0.741 (95% confidence interval [CI]: 0.635–1.871) and 0.717 (95% CI: 0.601–0.856), respectively. Hcy combined with the Framingham score demonstrated a significantly higher predictive value (0.852, 95% CI: 0.741–0.979). Long smoking history, long diabetes duration, high Framingham score, high SBP, high TC, high FBG, low HDL-C, and high Hcy levels are risk factors for cardio-cerebrovascular disease in elderly patients with T2DM. In addition, Hcy level combined with the Framingham score demonstrated superior predictive power for cardio- and cerebrovascular disease in elderly patients with T2DM.

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Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study

Xu,

Huo,

et al. 2024

Clin Exp Nephrol

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Impact of Diabetes on the Recurrence and Prognosis of Acute Kidney Injury in Older Male Patients: A 10-Year Retrospective Cohort Study

Cited by 5 publications

References 32 publications

Acute kidney injury in diabetic patients: A narrative review

Acute kidney injury in diabetic patients: A narrative review

Value of Hcy combined with Framingham score for predicting macrovascular disease in elderly patients with type 2 diabetes

Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study

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