Impact of diet on adult hippocampal neurogenesis

Stangl, Doris; Thuret, Sandrine

doi:10.1007/s12263-009-0134-5

Cited by 167 publications

(144 citation statements)

References 127 publications

(121 reference statements)

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“…Neurogenesis in the hippocampus is regulated by numerous elements, including neuropathological conditions such as ischemic episodes and diet [11,30]. Given that dietary factors have been proved to change the time course after ischemic neurodegeneration [66,77], and the same factors have been shown to modulate neurogenesis in the hippocampus [59], it is possible that the effects of diet on postischemic neurodegeneration are mediated by modulation of hippocampal neurogenesis. Additionally, dietary habits are an important component of lifestyle, which is recognized as one of the ischemic risk factors.…”

Section: The Importance Of Hippocampal Neurogenesis In Postischemic Bmentioning

confidence: 99%

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Pluta¹,

Bogucka‐Kocka²,

Ułamek-Kozioł³

et al. 2015

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Section: The Importance Of Hippocampal Neurogenesis In Postischemic Bmentioning

confidence: 99%

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Pluta¹,

Bogucka‐Kocka²,

Ułamek-Kozioł³

et al. 2015

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“…It appears that these low-molecular-weight non-nutrient components are able to impact on memory through their ability to exert effects directly on the brain's innate architecture for memory (3,47,142,143) . The concentrations of flavonoids and their metabolites that reach the brain are thought to be sufficiently high to exert pharmacological activity at receptors, kinases and transcription factors.…”

Section: Modulation Of Synaptic Plasticity and Neuro-cognitive Performentioning

confidence: 99%

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain

Spencer

2010

Proc. Nutr. Soc.

143

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The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance. Flavonoids mediate these effects via a number of routes, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation and a potential to promote memory, learning and cognitive function. Originally, it was thought that such actions were mediated by the antioxidant capacity of flavonoids. However, their limited absorption and their low bioavailability in the brain suggest that this explanation is unlikely. Instead, this multiplicity of effects appears to be underpinned by three separate processes: first, through their interactions with important neuronal and glial signalling cascades in the brain, most notably the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways that regulate prosurvival transcription factors and gene expression; second, through an ability to improve peripheral and cerebral blood flow and to trigger angiogenesis and neurogenesis in the hippocampus; third, by their capacity to directly react with and scavenge neurotoxic species and pro-inflammatory agents produced in the brain as a result of both normal and abnormal brain ageing. The present review explores the potential inhibitory or stimulatory actions of flavonoids within these three systems and describes how such interactions are likely to underlie neurological effects.

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“…The mechanisms seem to involve an indirect action on the dentate gyrus (DG) (Casadesus et al, 2004;Burke and Barnes, 2006;Rendeiro et al, 2012;Rendeiro et al, 2013). Such link between hippocampal neurogenesis, cognitive performance and ageing may represent a potential mechanism by which polyphenol-derived foods may improve memory (Stangl and Thuret, 2009). However, although epidemiological and pre-clinical studies have lent some support to the neurocognitive potential of polyphenols, human intervention results are less clear (Scholey et al, 2010;Field et al, 2011) and further work is still necessary to confirm these preliminary observations (Vauzour et al, 2016).…”

Section: Effects Of Polyphenols On Age-related Cognitive Decline and mentioning

confidence: 99%

Polyphenols and brain health

Vauzour

2017

OCL

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-Accumulating evidence suggests that diet and lifestyle can play an important role in delaying the onset or halting the progression of age-related health disorders and to improve cognitive function. A growing number of dietary intervention studies in humans and animals and in particular those using polyphenol-rich diets have been proposed to exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation and a potential to promote memory, learning, and cognitive functions. These effects appear to be underpinned by two common processes. First, they are capable of interactions with critical protein and lipid kinase signalling cascades in the brain, leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Second, they induce beneficial effects on the vascular system, leading to changes in cerebrovascular blood flow capable of causing enhance vascularisation and neurogenesis, two events important in the maintenance of cognitive performances. Together, these processes act to maintain brain homeostasis and play important roles in neuronal stress adaptation and thus polyphenols might have the potential to prevent the progression of neurodegenerative pathologies.

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Impact of diet on adult hippocampal neurogenesis

Cited by 167 publications

References 127 publications

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain

Polyphenols and brain health

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