2005
DOI: 10.1038/sj.pcan.4500825
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Impact of diet on prostate cancer: a review

Abstract: Epidemiological studies suggest that environmental factors may mediate the transformation of latent prostate cancer into clinically apparent tumors and that diet appears to influence this progression. Close correlations between average per capita fat intake and prostate cancer mortality internationally generated interest in underlying mechanisms for this link, such as through serum levels of androgens, free radicals, proinflammatory fatty acid metabolites, or insulin-like growth factor. Much interest currently… Show more

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Cited by 134 publications
(92 citation statements)
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“…The reason believed for this phenomenon is low animal fat intake together with a diet rich in fiber and soy. 1 In contrast, high-fat consumption and a low-phytochemical diet are very common in Western countries, with higher incidences of PCa (up to 4100 per 100 000 men). 2,3 Although there might be some problematic aspects with cancer registries in Far East countries, there is an additional evidence for the role of diet in migration studies.…”
Section: Introductionmentioning
confidence: 99%
“…The reason believed for this phenomenon is low animal fat intake together with a diet rich in fiber and soy. 1 In contrast, high-fat consumption and a low-phytochemical diet are very common in Western countries, with higher incidences of PCa (up to 4100 per 100 000 men). 2,3 Although there might be some problematic aspects with cancer registries in Far East countries, there is an additional evidence for the role of diet in migration studies.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, Swinnen et al [7] correlated androgen stimulation in prostate cancer cells with the accumulation of neutral lipids (triglyceride and cholesterol esters). Sonn et al [8] discovered that exogenous fat intake has also been correlated with prostate cancer mortality and serum androgen levels. Based on these studies, androgens are believed to play a significant role in lipogenesis involved in the progression to the AI phenotype but the underlying mechanisms of how this occurs remain to be elucidated.…”
Section: Introductionmentioning
confidence: 99%
“…Macro environmental influences are visible and faced in day-to-day life: lifestyle, air quality, diet and nutrition, chemical exposures, physical agents, radiation and a host of other factors. [7][8][9][10] Such factors have been instrumental in explaining variations of incidence at the global level as well as the biological behavior of a variety of cancers. 9,11,12 Macroenvironmental factors have largely influenced key biological events including cell-cycle regulation, translation and apoptosis in favor of abnormal cell growth.…”
Section: Introductionmentioning
confidence: 99%
“…A large number of studies have emphasized the role of environmental exposures and dietary nutrients, familial inheritance, aging and hormonal factors, which collectively manipulate the genetic architecture in support of excessive prostate cancer cell growth. 7,8,12,26 Race/ethnicity is also considered the second most common risk factor associated with the development of prostate cancer. 2,26 An estimated lifetime risk of prostate cancer between African-American and Caucasians is 18.1 and 16.1%, respectively.…”
Section: Introductionmentioning
confidence: 99%