Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL/6J mice

Janssen, Carola I.F.; Zerbi, Valerio; Mutsaers, Martina P. C.; Jong, Bas S.W. de; Wiesmann, Maximilian; Arnoldussen, Ilse A.C.; Geenen, Bram; Heerschap, Arend; Muskiet, Frits A. J.; Jouni, Zeina E.; Tol, Eric A.F. van; Gross, Gabriele; Homberg, Judith R.; Berg, Brian M.; Kiliaan, Amanda J.

doi:10.1016/j.jnutbio.2014.08.002

Cited by 90 publications

(63 citation statements)

References 84 publications

(136 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are previous reports describing the neurogenic potential of PUFAs in the hippocampus (54). In fact, at least part of the beneficial effects of PUFAs in age-related brain disorders have been attributed to their capacity to induce neurogenenesis in the hippocampus (55,56). However, in the current study, the inhibitions of either BDNF or GPR40 were capable of mitigating PUFA-induced neurogenesis in the hypothalamus only.…”

Section: Discussioncontrasting

confidence: 56%

n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus

et al. 2015

View full text Add to dashboard Cite

Apoptosis of hypothalamic neurons is believed to play an important role in the development and perpetuation of obesity. Similar to the hippocampus, the hypothalamus presents constitutive and stimulated neurogenesis, suggesting that obesity-associated hypothalamic dysfunction can be repaired. Here, we explored the hypothesis that n-3 polyunsaturated fatty acids (PUFAs) induce hypothalamic neurogenesis. Both in the diet and injected directly into the hypothalamus, PUFAs were capable of increasing hypothalamic neurogenesis to levels similar or superior to the effect of brain-derived neurotrophic factor (BDNF). Most of the neurogenic activity induced by PUFAs resulted in increased numbers of proopiomelanocortin but not NPY neurons and was accompanied by increased expression of BDNF and G-protein-coupled receptor 40 (GPR40). The inhibition of GPR40 was capable of reducing the neurogenic effect of a PUFA, while the inhibition of BDNF resulted in the reduction of global hypothalamic cell. Thus, PUFAs emerge as a potential dietary approach to correct obesity-associated hypothalamic neuronal loss.

show abstract

Section: Discussioncontrasting

confidence: 56%

n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Additionally, the activation and expression of key synaptic plasticity signaling effectors such as CREB, CamKII, syntaxin-3 and synapsin I, may be stimulated by omega-3 fatty acids (Bhatia et al, 2011;Chytrova et al, 2010;Vaynman et al, 2003;Vaynman et al, 2004). PUFAs have additionally been shown to stimulate synaptic plasticity at least in part by changing vesicular transport dynamics and altering neurogenesis (Cutuli et al, 2014;Gedalya et al, 2009;Janssen et al, 2015;Kodas et al, 2002;Lesa et al, 2003;Marza et al, 2008;Wurtman et al, 2006;Zimmer et al, 2000). Conversely, omega-3 fatty acid deficiency is associated with neurodevelopmental deficits, neurodegenerative disorders, and attenuated cognitive performance (Bhatia et al, 2011;Sable et al, 2013;Saugstad, 2006).…”

Section: Common Effectors? the Potential For Intersecting Mechanisms mentioning

confidence: 99%

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

2016

View full text Add to dashboard Cite

Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent studies indicate that voluntary exercise and environmental enrichment can positively influence both oligodendrogenesis and myelination, and that, in contrast, social isolation can negatively influence myelination. In this review we summarize studies addressing the influence of behavioral experiences on oligodendrocyte lineage cells and myelin, and highlight potential mechanisms including experience-dependent neuronal activity, metabolites, and stress effectors, as well as both local and systemic secreted factors. Although more study is required to better understand the underlying mechanisms by which behavioral experiences regulate oligodendrocyte lineage cells, this exciting and newly emerging field has already revealed that oligodendrocytes and their progenitors are highly responsive to behavioral experiences and suggest the existence of a complex network of reciprocal interactions among oligodendrocyte lineage development, behavioral experiences, and brain function. Achieving a better understanding of these relationships may have profound implications for human health, and in particular, for our understanding of changes in brain function that occur in response to experiences. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.

show abstract

“…The results were divided into the following categories: physiopathology of LCPUFAs [6], maternal nutrition during pregnancy and its relation to LCPUFAs, the newborn nutrition based on breast milk and infant formula and its link with LCPUFAs, LCPUFAs and its influence in the neuronal development during the first thousand days of a child's life and the consequences of lack of LCPUFAs during the first thousand days (Figure 1). …”

Section: Resultsmentioning

confidence: 99%

Optimization during the First Thousand Days of Child through Dietary Supplement with Lc-Pufas: Systematic Review of the Literature

Silva¹,

Reis²,

Sc³

et al. 2017

Matern Pediatr Nutr

View full text Add to dashboard Cite

Objective: To describe data on effects of LC-PUFAS in neuronal formation in the first thousand days of a child. Methods:A systematic review of 23 articles in the first quarter of 2015 from 2003 to 2015 in Medline, Scielo, Science Direct and Google Scholar. Languages: Portuguese, English and Spanish. Headings (MeSH): fatty acids; arachidonic acid; Omega 3; Omega-6; infant formula; child development; child nutrition; synapses and neurogenesis; child development; child nutrition; synapses and neurogenesis. Inclusion criteria: the LC-PUFAS approach, neuronal training and the first thousand days of children, isolated or associated. Results:The first thousand days of a child involving rapid growth and physical and mental development. There is no evidence that the foetus has docosahexaenoic acid omega 3 family (DHA) sufficient to meet the demand of its neuronal metabolism. Observational studies indicate that DHA intake during pregnancy promotes a variety of positive results in the development of the newborn. The postnatal supplementation with LC-PUFAs for breastfeeding or formula with LC-PUFAs, if not exclusive breastfeeding is associated with better neurological development indices.Conclusion: supplementation with LC-PUFAs is essential to improve the neurological development of children. The intake of DHA promotes better cognitive and visual results compared to no feeding of the substance.

show abstract

Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL/6J mice

Cited by 90 publications

References 84 publications

n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus

n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

Optimization during the First Thousand Days of Child through Dietary Supplement with Lc-Pufas: Systematic Review of the Literature

Contact Info

Product

Resources

About