Impact of dietary supplementation with Echinacea purpurea on growth performance, immunological, biochemical, and pathological findings in broiler chickens infected by pathogenic E. coli

Hashem, Mohamed A.; Neamat‐Allah, Ahmed N. F.; Hammza, Heba E E; Abou-Elnaga, Hala M.

doi:10.1007/s11250-019-02162-z

Cited by 38 publications

(21 citation statements)

References 30 publications

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“…Some of the modern anticancer drugs such as vincristine and vinblastine are plantbased (Wangchuk 2018). Experimental evidence in animal models revealed that plant extracts have a wide variety of beneficial effects including immunomodulation, hepatoprotection, and renoprotection (Abdallah et al 2019;Hashem et al 2019;Neamat-Allah et al 2020;El-Murr et al 2019). According to the mentioned observations, herbal extracts provide a promising tool for the treatment of some health treating diseases.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Thymus vulgaris aqueous extract has a hepato-protective and reno-protective effect in oxidized oil-induced toxicity (Abdallah et al 2019). Researchers demonstrated that some natural products have immunomodulating effects and can be used as a supplement against infection (Hashem et al 2019;Neamat-Allah et al 2020;El-Murr et al 2019). Based on the studies mentioned above, plant-based natural products are a promising candidate for pharmaceutical and nutraceutical applications.…”

Section: Introductionmentioning

confidence: 99%

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Preventive effect of Stachys lavandulifolia against gentamicin-induced oxidative stress and nephrotoxicity in rats

et al. 2020

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Gentamicin (GM) is an effective antibiotic against gram-negative bacterial infection. However, GM can produce nephrotoxicity. Stachys lavandulifolia Vahl. (SL) is extensively used in folk medicine as herbal tea and has strong antioxidative effects. The aim of this study was to investigate the protective effect of SL on GM-induced nephrotoxicity in rats. In this study, forty-two male Wistar rats were randomly divided into six equal groups (N = 7 each): control (group I), GM-treated (group II), SL200 mg/kg + GM-treated (group III), SL400 mg/kg + GM-treated (group IV), SL200 mg/kg-treated (group V), and SL400 mg/kg-treated (group VI) groups. The treatment procedures continued for 10 days. At the end of the experiment, serum and the kidneys of all groups were harvested for histological and biochemical examination. No statistical significant improvement in histological and biochemical indices was shown at 200 mg/kg of SL treatment in group III compared with group II; however, at 400 mg/kg of SL, normalized serum levels of uric acid (P < 0.001), urea (P < 0.001), creatinine (P < 0.01), and total proteins (P < 0.05) were shown in group IV. Treatment with SL400 mg/kg also corrected the increased relative kidney weight in GM-treated animals (P < 0.05). GM nephrotoxicity was shown by elevated levels of malondialdehyde (P < 0.001) and decreased amounts of catalase (P < 0.001), superoxide dismutase (P < 0.01), and glutathione (P < 0.01) in renal tissue. The oxidative injury induced by GM was prevented by SL400 mg/kg treatment. Such treatment also normalized abnormal renal histology induced by GM. These data suggest that treatment with SL extract may be helpful to reduce gentamicin-induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preventive effect of Stachys lavandulifolia against gentamicin-induced oxidative stress and nephrotoxicity in rats

et al. 2020

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“…These changes were ameliorated following treatment with Echinacea or curcumin. In consistence, Rezaieet al 2013and Hashem et al (2019) found that the infected broiler chicks supplemented with Echinacea purpurea showed slight degeneration of hepatocytes and slight inflammatory cell infiltration. El-Agamy (2010) and Kyunget al (2018) also reported that the oral administration of curcumin ameliorated aflatoxin-B1 induced liver damage in rats and counteracts oxidative stress caused by aflatoxin.…”

Section: Histopathological Findingsmentioning

confidence: 94%

Ameliorative effect of Echinacea purpurea and curcumin on dexamethasone-induced immunosuppressive rabbits

Ibrahim¹,

Saleh

Hassan³

et al. 2020

Kafrelsheikh Veterinary Medical Journal

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Objectives: This study was delineated to investigate the ameliorative effect of Echinacea purpurea and curcumin against oxidative stress and immunosuppression induced by dexamethasone in rabbits. Methods: A total of 20 healthy rabbits were used in this study and were randomly classified into 4 groups of 5 each. The 1 st group (non-treated) was served as a control, the 2 nd group intramuscularly medicated with dexamethasone (2 mg/kg) 3 times at 6 hours interval, the 3 rd group medicated with dexamethasone at the same dose then received E. purpurea (130 mg/kg) orally day after day for 21 days, and the 4 th group medicated with dexamethasone at the same dose then received curcumin (400 mg/kg) orally every day for 21 days. Blood and serum samples were collected after 1, 7, and 14 days post-dosing. Results: Dexamethasone medicated group showed a significant decrease in WBCS, lymphocytes, neutrophils, and monocytes at the 1 st , 7 th, and 14 th day, but E. purpurea and curcumin medicated groups showed significant improvement in total and differential leucocytic count. Also, both plants showed a significant increase in lysozymes and nitric oxide against the suppressive effect of dexamethasone. Here, the dexamethasone group showed a significant decrease in serum catalase (CAT) and significant elevation in serum malondialdehyde (MDA) at 1 st and 7 th-day posttreatment. E. purpurea and curcumin groups showed a significant increase in serum CAT and significant depletion in MDA levels. Injection of dexamethasone significantly decreased the serum levels of total protein, albumin, and globulin as compared to the control group. These parameters were significantly increased after treatment with E. purpurea and curcumin. Treatment with E. purpurea or curcumin ameliorated tissue damages of liver, kidney, and spleen induced by dexamethasone. Conclusion: Treatment with Echinacea purpurea or curcumin could ameliorate oxidative stress and immunosuppression induced by dexamethasone in rabbits.

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“…Recently, the use of natural ingredients as immunomodulators for enhancing resistance and immunity in various live organisms has been proposed (Abdallah, Nasr El‐Deen, Neamat‐Allah, & Abd El‐Aziz, ; Badr et al, ; Hashem, Neamat‐Allah, Hammza, & Abou‐Elnaga, ; Neamat‐Allah, El‐Murr, & Abd El‐Hakim, ; Neamat‐Allah, Mahmoud, & Abd El Hakim, ; Prasanna, Ashraf, & Essam, ). β‐glucan (βG) is known as natural immunomodulator.…”

Section: Introductionmentioning

confidence: 99%

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

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Three hundred Oreochromis niloticus were divided into five groups; the control fish (CNT) were fed a basal diet, beta glucan (βG) group was fed 0.5 g/kg−1 βG, atrazine (ATZ) group was exposed to 1/5 96‐hr LC50 (1.39 mg/L) ATZ, the (βG/ATZ) group was fed βG while being exposed to ATZ, and the (βG then ATZ) group was supplemented with βG for fifteen days before exposed to ATZ. ATZ exposure caused a decline in growth that was ameliorated by βG. ATZ reduced the levels of total and different types of leucocytes. Additionally, ATZ exposure caused reductions in total proteins, globulins, α 1‐globulin, α 2‐globulin, ɤ‐globulin, immunoglobulin M, lysozymes, superoxide dismutase, nitric oxide and catalase but increases in hepatic transaminases and malondialdehyde without any variations in albumin and β‐globulin. Exposure to ATZ also resulted in a rise in the mRNA level of IL‐8. In contrast, expression of IgM, SOD and CAT were decreased in the tilapias exposed to ATZ. Exposure to ATZ increases the susceptibility response to Aeromonas sobria challenge, as indicated by an increase in cumulative mortality post‐challenge. Supplementation with βG fifteen days before (βG then ATZ group), counteracted the adverse effects of ATZ on the immune, biochemical and antioxidants values, though only slight alleviation was observed with simultaneous treatment (βG/ATZ group). Our results established that ATZ has adverse impacts on immune responses, antioxidant equilibrium and its related genes. While, supplementation with βG before exposure to ATZ may be valuable for counteracting the possible damage caused by ATZ water pollution than its simultaneous treatment with ATZ.

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Impact of dietary supplementation with Echinacea purpurea on growth performance, immunological, biochemical, and pathological findings in broiler chickens infected by pathogenic E. coli

Cited by 38 publications

References 30 publications

Preventive effect of Stachys lavandulifolia against gentamicin-induced oxidative stress and nephrotoxicity in rats

Preventive effect of Stachys lavandulifolia against gentamicin-induced oxidative stress and nephrotoxicity in rats

Ameliorative effect of Echinacea purpurea and curcumin on dexamethasone-induced immunosuppressive rabbits

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

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