2016
DOI: 10.1371/journal.pone.0159633
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Impact of Dietary Tomato Juice on Changes in Pulmonary Oxidative Stress, Inflammation and Structure Induced by Neonatal Hyperoxia in Mice (Mus musculus)

Abstract: Many preterm infants require hyperoxic gas for survival, although it can contribute to lung injury. Experimentally, neonatal hyperoxia leads to persistent alterations in lung structure and increases leukocytes in bronchoalveolar lavage fluid (BALF). These effects of hyperoxia on the lungs are considered to be caused, at least in part, by increased oxidative stress. Our objective was to determine if dietary supplementation with a known source of antioxidants (tomato juice, TJ) could protect the developing lung … Show more

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Cited by 8 publications
(9 citation statements)
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“…Biologically significant carotenoids include α-carotene, β-carotene, and β-cryptoxanthin, which have pro-vitamin A activity. Lycopene and lutein, while not possessing pro-vitamin A activity, are effective anti-oxidants [ 12 , 13 , 14 ]. Carotenoids are found primarily in foods of plant origin, including leafy green and red, yellow, and orange fruits and vegetables [ 12 , 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…Biologically significant carotenoids include α-carotene, β-carotene, and β-cryptoxanthin, which have pro-vitamin A activity. Lycopene and lutein, while not possessing pro-vitamin A activity, are effective anti-oxidants [ 12 , 13 , 14 ]. Carotenoids are found primarily in foods of plant origin, including leafy green and red, yellow, and orange fruits and vegetables [ 12 , 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, there is a pronounced lack of standardisation of BPD mouse models, with over 41 different oxygen-exposure protocols reported in a 30-month period alone ( Silva et al, 2015 ). Although initially very high (90-100%) oxygen concentrations were employed in the past as an injurious stimulus in BPD models, and indeed, still are by many groups; there has been a gradual shift in the degree of oxygen toxicity employed, with increased instances of oxygen concentrations below 80% O 2 becoming increasingly evident in recent published studies ( Bouch et al, 2016 , 2015 ; Ehrhardt et al, 2016 ; Maduekwe et al, 2015 ; Reyburn et al, 2016 ; Sozo et al, 2015 ; Wang et al, 2014 ; Yee et al, 2016 ). In some instances, the lack of model standardisation might have resulted in opposite findings when evaluating the same candidate therapeutic intervention ( Silva et al, 2015 ).…”
Section: Discussionmentioning
confidence: 99%
“…The effects of supplementing individual compounds, such as lycopene, merit much consideration prior to implementation. Clinical trials with other single small molecules, like vitamin E, vitamin C, or β-carotene have largely been disappointing [ 40 ], and likewise, laboratory experiments using single antioxidants have shown them to be largely ineffective in ameliorating hyperoxia-induced injury [ 3 , 41 ]. An imbalance between different antioxidants can potentially result in tissue damage [ 3 , 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Clinical trials with other single small molecules, like vitamin E, vitamin C, or β-carotene have largely been disappointing [ 40 ], and likewise, laboratory experiments using single antioxidants have shown them to be largely ineffective in ameliorating hyperoxia-induced injury [ 3 , 41 ]. An imbalance between different antioxidants can potentially result in tissue damage [ 3 , 42 ]. Antioxidant defense systems are multifaceted, thus supplementation with a single molecule, unless a deficiency is present, is likely to have little effect on the development of a disease or adverse outcome.…”
Section: Discussionmentioning
confidence: 99%
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