Impact of different biochemical markers in serum of patients with benign and malignant liver diseases

Zakhary, Nadia I.; El‐Merzabani, Mahmoud M.; El-Sawi, Nagwa M.; Saleh, Saleh M.; Moneer, Manar M.; Mohamad, Ragaa Hosny

doi:10.1016/j.jare.2010.08.001

Cited by 9 publications

(12 citation statements)

References 32 publications

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“…In the present study, HCC patients were more common in males than females; that number of males were more than females, these results are similar to Zakhary et al 2011 who reported that males represented 70.8% of all patients in HCC group, with 83.3% of patients over 50 years. In our study, we found that the mean value of AST, ALT , Bilirubin , INR and GGT were higher in HCC patients than that of the control group ,however albumin was lower in HCC group than that of the other group.…”

Section: P-valuesupporting

confidence: 91%

Study: The Correlation Between Homa-Ir and Hepatocellular Carcinoma Development in Hepatitis C Patients

Ramadan

2014

Al-Azhar Journal of Pharmaceutical Sciences

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ABSTRACT:Background: Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer worldwide which accounts for 80%-90% of primary liver cancer. It is characterized by a very poor prognosis. Outcome of HCC depends mainly on its early diagnosis. Serum α-fetoprotein (AFP) is the marker that has been widely used for screening and diagnosis of HCCs. However, development of false-negative or false-positive rates with (AFP) was as high as 30%-40% for patients with small HCCs. Insulin resistance (IR) is found to occur early in the course of Hepatitis C (HCV) infection, independent of BMI (body mass index), stage of liver disease and presence or absence of diabetes. Recently, it has been observed the synergistic effect of IR and viral hepatitis in HCC development among HCV infected patients. Therefore, this study was done to investigate the correlation between HOMA-IR and HCC patients. Methods: Clinical and biochemical characteristics were investigated for 50 HCC patients related HCV and 50 normal controls. HCC patients were diagnosed by ultrasound assessment, abdominal triphasic CT and serum AFP. Homeostasis model assessment of IR (HOMA-IR) was investigated to all 100 participants. Results: Obese patients in HCC group showed significantly higher frequency of high HOMA-IR when compared to non-obese patients (P=0.001). HOMA-IR value increases as tumor size of HCC increases.

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Section: P-valuesupporting

confidence: 91%

Study: The Correlation Between Homa-Ir and Hepatocellular Carcinoma Development in Hepatitis C Patients

Ramadan

2014

Al-Azhar Journal of Pharmaceutical Sciences

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“…The diagnosis of HCC could be very difficult in high-risk patients when these patients had low AFP level or tumors mimicking HCC. It has been estimated that up to 75% of patients with small HCC and 20% of patients with large HCC may have normal serum AFP level that could escape from HCC surveillance [ 37 , 38 ]; however, several investigators concluded that AFP fails as a reliable marker, mainly because it shows poor sensitivity and specificity [ 7 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…HCC surveillance with serum AFP level and ultrasonography has been recommended for patients with cirrhosis. Although the detection of serum AFP level is well established in the screening and diagnostic purpose for HCC, a major shortcoming is that serum AFP is insensitive for the early cancer detection [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Interleukin-6 and Interleukin-10 as Biomarkers for Hepatocellular Carcinoma in Egyptian Patients

Othman

Aref

Mohamed³

et al. 2013

ISRN Hepatology

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Interleukin-10 (IL-10) and interleukin-6 (IL-6) have been reported to be related to hepatocellular carcinoma (HCC) prognosis. This study aimed to investigate the clinical usefulness of serum levels of IL-6 and IL-10 as biomarkers for HCC among high-risk patients. Materials and Methods. 80 individuals were enrolled in this study; they were categorized into 4 groups: group 1 healthy individuals (NC) (n = 20), group 2 chronic hepatitis C virus (HCV) patients (n = 20), group 3 cirrhotic patients (LC) (n = 20), and HCC group (n = 20). Using ELISA technique serum levels of IL-6, IL-10, and alpha fetoprotein (AFP) were evaluated in all groups. Results. The mean serum levels of IL-6 were significantly higher in HCC than in LC, HCV, and NC groups (13.99 ± 1.80, 7.49 ± 0.43, 5.78 ± 0.74, and 2.57 ± 0.31), respectively (P < 0.05); also the serum levels of IL-10 were significantly higher in HCC compared with LC, HCV, and NC groups (13.69 ± 1.89, 7.37 ± 0.53, 5.18 ± 0.6, and 3.31 ± 0.42) (P < 0.05). We also found that the tumor size is correlated strongly with IL-6 and IL-10 levels (r = 0.925, P < 0.001; r = 0.821, P < 0.001), respectively. Conclusion. The combination of those markers may help to identify a group of HCC patients with low AFP.

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“…There is a move to younger age in the developing countries which may be accredited to the rise of both hepatitis B and or C infections at a younger generation. Old age is an independent risk factor for HCC, especially in areas where HCV infection is endemic [15]. El Zayadi and his colleagues [16] stated that the most predominant age group was (40-59 years).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Serum Heat Shock Protein 70 in Hepatocellular Carcinoma Patients

Elhammar¹,

Ibrahim

El-Naggar

et al. 2019

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Impact of different biochemical markers in serum of patients with benign and malignant liver diseases

Abstract: The only hope for effective treatment of liver cancer lies in early detection or screening for populations who are at high risk for developing liver cancer. This study was designed to study

Cited by 9 publications

References 32 publications

Study: The Correlation Between Homa-Ir and Hepatocellular Carcinoma Development in Hepatitis C Patients

Study: The Correlation Between Homa-Ir and Hepatocellular Carcinoma Development in Hepatitis C Patients

Serum Levels of Interleukin-6 and Interleukin-10 as Biomarkers for Hepatocellular Carcinoma in Egyptian Patients

Diagnostic Value of Serum Heat Shock Protein 70 in Hepatocellular Carcinoma Patients

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