Impact of Different e-Cigarette Generation and Models on Cognitive Performances, Craving and Gesture: A Randomized Cross-Over Trial (CogEcig)

Abstract

Introduction: Most electronic-cigarettes (e-cigarette) are designed to look like traditional cigarettes and simulate the visual, sensory, and behavioral aspects of smoking traditional cigarettes. This research aimed to explore whether different e-cigarette models and smokers' usual classic cigarettes can impact on cognitive performances, craving and gesture.Methods: The study is randomized cross-over trial designed to compare cognitive performances, craving, and gesture in subjects who used first generation electronic cigarettes, second generation electronic cigarettes with their usual cigarettes. (Trial registration: ClinicalTrials.gov number NCT01735487).Results: Cognitive performance was not affected by “group condition.” Within-group repeated measures analyses showed a significant time effect, indicating an increase of participants' current craving measure in group “usual classic cigarettes (group C),” “disposable cigalike electronic cigarette loaded with cartridges with 24 mg nicotine (group H), second generation electronic cigarette, personal vaporizer model Ego C, loaded with liquid nicotine 24 mg (group E). Measures of gesture not differ over the course of the experiment for all the products under investigationConclusion: All cognitive measures attention, executive function and working memory are not influenced by the different e-cigarette and gender showing that in general electronics cigarettes could become a strong support also from a cognitive point of view for those who decide to quit smoking. It seems that not only craving and other smoke withdrawal symptoms but also cognitive performance is not only linked to the presence of nicotine; this suggests that the reasons behind the dependence and the related difficulty to quit smoking needs to be looked into also other factors like the gesture.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT01735487.

The Impact of E-cigarette Usage on Cognitive Performance Level among University Students in Malaysia: A case-controlled study

“…This study's nding is similar to a randomized crossed-over control trial, which the researchers explored the effect of different e-cigarette containing 24 mg to 0 mg nicotine. This study demonstrated that there was no signi cant cognitive performance difference between these two different groups (13). It has also been shown that while low doses of nicotine exposure might improve cognitive functions, higher doses could impair cognitive functions.…”

Asociación entre el uso de cigarrillos electrónicos y cigarrillos convencionales en adolescentes españoles

“…El uso regular de cigarrillos electrónicos con contenido de nicotina conduce a una dependencia de la nicotina (Case et al, 2018;Hammond et al, 2021), y los fumadores cambian al tabaco para obtener más nicotina rápidamente (Grana, Benowitz y Glantz, 2014;O'Connell et al, 2019). El hecho de que incluso los cigarrillos electrónicos sin nicotina aumentaran el consumo posterior de cigarrillos convencionales puede explicarse porque ambos comparten el mismo mimetismo, es decir, movimientos de mano a boca, inhalación y exhalación de humo (Caponnetto et al, 2013(Caponnetto et al, , 2017Park et al, 2020).…”

The effect of e-cigarettes on cognitive function: a scoping review

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