Changes in vertical column concentration, size distribution, and surface concentration of aerosol associated with the lockdown imposed by the COVID-19 pandemic in 2020 over the Ahmedabad region in Gujarat State, India, were analyzed. The results are compared with changes over selected Indo-Gangetic Plain (IGP) regions. On 25 March 2020, the prime minister of India declared a complete lockdown throughout the country and later lifted restrictions in a phased manner. Aerosol optical depth (AOD) over the Ahmedabad region on 29 March dropped to as low as 0.11, and in the first two weeks of lockdown, the weekly average AOD was only 0.18. On almost all days of the lockdown period, AOD over the Ahmedabad region was lower than the decadal mean. It was found that the Ahmedabad region responded differently to lockdown conditions compared to the IGP regions. During the first lockdown phase, AOD decreased by about 29% compared to the pre-lockdown period over the Ahmedabad region. However, the average reduction over the IGP was much more, about 50%. The average Angstrom exponent (AE) of 0.96 during the pre-lockdown period over the Ahmedabad region increased phase-wise to 1.36 during the L3 lockdown phase, indicating dominance of fine-mode particles during the lockdown period. It suggests a reduction in anthropogenically produced coarse-mode particles, typically dust produced by vehicular movement, construction, and industrial activities. However, on the other hand, over the IGP region, the high dominance of fine-mode particles during the pre-lockdown period had changed to a high dominance of coarse-mode particles, especially over the Delhi region. This indicates a reduction in anthropogenically produced fine-mode particles, which are mainly generated by fossil and biofuels/biomass combustion, over the IGP region by lockdown conditions. Within a few days of lockdown, PM2.5 was reduced by 64% and 76% over the Ahmedabad and Delhi regions, respectively. The lockdown imposed by the pandemic provided an excellent opportunity to ascertain background aerosol conditions in the atmosphere.