Impact of donor bacteremia on outcome in organ transplant recipients

Singh, Nina

doi:10.1053/jlts.2002.0080975

Cited by 26 publications

(19 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been estimated that at least 5% of donors have positive blood cultures prior to organ procurement (1). Studies have shown that transmission of infection from bacteremic donors to recipients is uncommon and, in general, not associated with poor outcomes (2,3). However, most published reports come from single center studies that may have failed to detect differences in outcomes due to lack of statistical power.…”

mentioning

confidence: 97%

Donor positive blood culture is associated with delayed graft function in kidney transplant recipients: a propensity score analysis of the UNOS database

Huamán

Vilchez

Mei

et al. 2016

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 97%

Donor positive blood culture is associated with delayed graft function in kidney transplant recipients: a propensity score analysis of the UNOS database

Huamán

Vilchez

Mei

et al. 2016

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…However, transmission can occur despite the adoption of defined screening and prevention strategies, and may result in increased morbidity and mortality (3)(4)(5). Organs from deceased donors with severe infections caused by susceptible bacteria have been procured and successfully transplanted with no evidence of transmission of infection, increase in rejection or influence on graft survival (6)(7)(8)(9). More recently, reports of patients admitted to the intensive care unit (ICU) and exposed to multidrug-resistant (MDR) bacteria are available and, therefore, potential organ donors can be exposed to these organisms (3,5).…”

Section: Introductionmentioning

confidence: 99%

Outcome of Transplantation Using Organs From Donors Infected or Colonized With Carbapenem-Resistant Gram-Negative Bacteria

Mularoni

Bertani

Vizzini

et al. 2015

American Journal of Transplantation

115

116

View full text Add to dashboard Cite

Donor-derived infections due to multidrug-resistant bacteria are a growing problem in solid organ transplantation, and optimal management options are not clear. In a 2-year period, 30/214 (14%) recipients received an organ from 18/170 (10.5%) deceased donors with infection or colonization caused by a carbapenemresistant gram-negative bacteria that was unknown at the time of transplantation. Among them, 14/30 recipients (47%) received a transplant from a donor with bacteremia or with infection/colonization of the transplanted organ and were considered at high risk of donor-derived infection transmission. The remaining 16/30 (53%) recipients received an organ from a nonbacteremic donor with colonization of a nontransplanted organ and were considered at low risk of infection transmission. Proven transmission occurred in 4 of the 14 high-risk recipients because donor infection was either not recognized, underestimated, or not communicated. These recipients received late, short or inappropriate posttransplant antibiotic therapy. Transmission did not occur in high-risk recipients who received appropriate and prompt antibiotic therapy for at least 7 days. The safe use of organs from donors with multidrug-resistant bacteria requires intra-and interinstitutional communication to allow appropriate management and prompt treatment of recipients in order to avoid transmission of infection.

show abstract

“…The most frequent cause of bacterial endocarditis is gram-positive cocci, mainly streptococci and staphylococci (13,14). The virulence of these germs is not identical and in particular the pathogens responsible for the endocarditis in the donors that we present, coagulasenegative Staphylococcus sensitive to methicillin and Streptococcus viridans, are not very virulent, in relative terms, and the documented risk of transmission of infection due to gram-positive bacteria with the grafts is low (15,16). The antibiotic treatment for endocarditis due to these bacteria tends to be effective: cloxacillin and aminoglycosides against staphylococci sensitive to methicillin and b-lactams and aminoglycosides against Streptococcus viridans (14).…”

Section: Discussionmentioning

confidence: 88%

Successful Liver and Kidney Transplantation From Cadaveric Donors With Left-Sided Bacterial Endocarditis

Caballero

López-Navidad

Perea

et al. 2005

American Journal of Transplantation

View full text Add to dashboard Cite

Bacterial infections are frequent in cadaveric organ donors and can be transmitted to the transplantation recipient, which could have devastating consequences for the recipients if adequate preventive measures are not adopted. Infection by the bacteria responsible for the endocarditis in the respective donors was not transmitted to any of the recipients. Six of the seven recipients were alive with normal-functioning grafts after between 13 and 24 months' follow-up. Transplantectomy was performed on one kidney recipient due to thrombosis of the renal vein of the graft not related to the endocarditis.Liver and kidney transplantation from donors dying from bacterial endocarditis can be performed without causing the transmission of infection to the recipient or the dysfunction of the graft.

show abstract

Impact of donor bacteremia on outcome in organ transplant recipients

Cited by 26 publications

References 6 publications

Donor positive blood culture is associated with delayed graft function in kidney transplant recipients: a propensity score analysis of the UNOS database

Donor positive blood culture is associated with delayed graft function in kidney transplant recipients: a propensity score analysis of the UNOS database

Outcome of Transplantation Using Organs From Donors Infected or Colonized With Carbapenem-Resistant Gram-Negative Bacteria

Successful Liver and Kidney Transplantation From Cadaveric Donors With Left-Sided Bacterial Endocarditis

Contact Info

Product

Resources

About