Impact of Donor–Recipient Race Matching on Survival After Lung Transplantation: Analysis of Over 11,000 Patients

Allen, Jeremiah G.; Weiss, Eric S.; Merlo, Christian A.; Baumgartner, William A.; Conte, John V.; Shah, Ashish S.

doi:10.1016/j.healun.2009.06.012

Cited by 33 publications

(27 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another explanation might be a difference between the donor and the recipient ethnicity as it was suggested in earlier studies that race matching resulted in an improvement in long-term survival. 33 However, we were unable to retrieve data regarding the donor ethnicity in this study and therefore could not determine its influence on BOS onset.…”

Section: Discussionmentioning

confidence: 98%

Lung transplantation in cystic fibrosis patients in Israel: The importance of ethnicity and nutritional status

Levine

Prais

Raviv

et al. 2017

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Lung transplantation in cystic fibrosis patients in Israel: The importance of ethnicity and nutritional status

Levine

Prais

Raviv

et al. 2017

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…The higher number of SNVs in race non-concordant transplant donor and recipient compared to raceconcordant transplants may be associated with poorer outcomes. (10,(47)(48)(49). Greater HLA mismatch in race non-concordant transplants is a potential contributor (10,50).…”

Section: Discussionmentioning

confidence: 99%

Donor-derived mitochondrial DNA variant peptides elicit allo-specific immune response in transplant patients

Marishta

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

BACKGROUND: Mitochondrial DNA (mtDNA) nonsynonymous single nucleotide variants (SNVs) between transplant donor stem cells and recipient trigger alloimmune responses and transplant rejection. Whether mt SNVs trigger alloimmune responses in solid-organ transplantation remains unknown, particularly in the background of immunodominant human leukocyte antigens mismatches. This study characterizes mtDNA SNVs and tests if donor-derived mitochondrial peptides trigger alloimmune responses in solid-organ transplantation. METHODS: To count and compare SNVs between donor and recipient (D-R) lung transplant pairs (n = 163), mtDNA was isolated from pre-transplant D-R blood and sequenced. The number of SNVs was compared for D-R demographic groups. We identified nonsynonymous SNVs, constructed 20mer peptides with donor-or recipient-derived amino acid sequences, and used ELISpot assay to test allospecific immune response by interferon gamma (IFNγ) release. To test if similar phenomena occur in other solid-organ transplants, we repeated the analyses in 19 heart transplant D-R pairs. RESULTS: We identified a median of 39 mtDNA SNVs (IQR= 32 -53) per D-R lung transplant pair, of which a median of 6 (IQR = 4 -9) SNVs were nonsynonymous. SNVs were predominantly located at MT-CYB, MT-ATP6, and MT-ND3 genes. The number of SNVs was higher in D-R race non-concordant pairs than in race-concordant pairs, p = 0.015. Donor-derived mt peptides triggered a 19.8-fold higher IFNγ release compared to recipient-derived peptide, p<0.001. Similar findings were observed in heart transplant patients. CONCLUSIONS: Donor-derived mitochondrial peptides trigger allo-specific immune responses after solid-organ transplantation.

show abstract

“…As previous research regarding the effect of gender on survival after LTx is conflicted, our findings do not resolve the controversy on the influence of this factor. The association between black donor race and increased mortality after LTx has been previously reported and was substantiated by our analysis.…”

Section: Discussionmentioning

confidence: 99%

Transfusion with packed red blood cells while awaiting lung transplantation is associated with reduced survival after lung transplantation

Hayes

Tumin

Yates

et al. 2016

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

Impact of Donor–Recipient Race Matching on Survival After Lung Transplantation: Analysis of Over 11,000 Patients

Cited by 33 publications

References 26 publications

Lung transplantation in cystic fibrosis patients in Israel: The importance of ethnicity and nutritional status

Lung transplantation in cystic fibrosis patients in Israel: The importance of ethnicity and nutritional status

Donor-derived mitochondrial DNA variant peptides elicit allo-specific immune response in transplant patients

Transfusion with packed red blood cells while awaiting lung transplantation is associated with reduced survival after lung transplantation

Contact Info

Product

Resources

About