Impact of Donor Smoking History on Post Heart Transplant Outcomes: A Propensity Matched Analysis of the ISHLT Registry

Hussain, Zeeshan; Yu, Mingxi; Wozniak, Amy; Kim, D.; Krepostman, Nicolas; Liebo, Max; Raichlin, Eugenia; Heroux, Alain; Joyce, Cara; Basha, Haseeb Ilias

doi:10.1016/j.healun.2020.01.1212

Cited by 2 publications

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“…Although the number of donors with a history of smoking has consistently decreased from 40% in 1995 to 15% in 2018 [3], organs from donor who smoked are associated with a 3% lower 1-year survival following heart transplantation as well as a reduced 5-year survival [82].…”

Section: Tobaccomentioning

confidence: 99%

Management of long-term cardiovascular risk factors post organ transplant

Fuente-Mancera

Forado-Bentar

Farrero

2021

Current Opinion in Organ Transplantation

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Purpose of reviewCardiovascular disease is one of the leading causes of death in solid organ transplant (SOT) recipients. Early identification of cardiovascular risk factors and their adequate management in this population is key for prevention and improved outcomes. Recent findingsApproximately 80% of SOT present one or more cardiovascular risk factors, with increasing prevalence with time posttransplantation. They are due to the interplay of pretransplant conditions and metabolic consequences of immunosuppressive agents, mainly corticosteroids and calcineurin inhibitors. Among the pharmacological management strategies, statins have shown an important protective effect in SOT. SummaryStrict surveillance of cardiovascular risk factors is recommended in SOT due to their high prevalence and prognostic implications. Further studies on the best managements strategies in this population are needed.

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Section: Tobaccomentioning

confidence: 99%

Management of long-term cardiovascular risk factors post organ transplant

Fuente-Mancera

Forado-Bentar

Farrero

2021

Current Opinion in Organ Transplantation

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“…Five-year follow-up results of 18 randomized trials demonstrated that smoking was an important predictor of adverse outcomes after percutaneous coronary intervention (PCI) with stent implantation [14] . In heart transplant, donor smoking was related to the increased rate of mortality and graft failure [15] . Therefore, smoking might promote unfavourable prognoses in cardiac BS by increasing in ammatory reactions.…”

Section: Discussionmentioning

confidence: 99%

New insight into therapeutic strategy and prognostic predictors in patients with cardiac Behçet's Syndrome: from the Shanghai Behçet's Syndrome database

Bao

Hou

Cai

et al. 2022

Preprint

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Background Cardiac Behçet’s syndrome (cardiac BS) is rare but lethal. And the influencing factors of prognoses in cardiac BS are not clear. This study was conducted to summarize the features of cardiac BS and find the predictors of unfavourable prognoses for cardiac BS patients. Methods Sixty-six cardiac BS patients were included from 1467 BS patients in the Shanghai Behçet’s syndrome database. The median follow-up duration was 4.0 (2.0–7.0) years. The unfavourable prognosis was defined as a compound event containing all-cause death and rehospitalization related to worsened cardiac lesions or postoperative complications. Logistic regression analyses were performed to evaluate the predictors of unfavourable prognoses. Results In this study, the mortality rate of cardiac BS patients was 10.61% (7/66), and 22 (33.33%) patients experienced two or more surgeries. Ninety-six cases were collected from 66 cardiac BS patients. The effective rates of postoperative biological agents and Janus kinases (JAK) inhibitors in cardiac BS patients were 88.89% (16/18) and 81.25% (13/16) respectively. Former smoking, valve replacement or repairment and poor compliance were found to be the independent risk factors of unfavourable prognoses; preoperative immunosuppressive therapies and postoperative immunosuppressive therapies were independent protective factors for unfavourable prognoses in total cardiac BS. In 65 cases of cardiac BS after aortic valve surgeries, former smoking was an independent risk factor for unfavourable prognoses. Bentall procedure, postoperative traditional DMARDs, postoperative JAK inhibitors or biological agents were independent protective factors for unfavourable prognoses in cardiac BS patients after aortic valve surgeries. Conclusion Both preoperative immunosuppressive therapies and postoperative immunosuppressive therapies are necessary for cardiac BS patients. Bentall procedure is recommended to be performed in BS patients with severe AR. Besides biological agents, JAK inhibitors can be used in cardiac BS patients after aortic valve surgeries for promoting favourable outcomes.

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Impact of Donor Smoking History on Post Heart Transplant Outcomes: A Propensity Matched Analysis of the ISHLT Registry

Cited by 2 publications

References 0 publications

Management of long-term cardiovascular risk factors post organ transplant

Management of long-term cardiovascular risk factors post organ transplant

New insight into therapeutic strategy and prognostic predictors in patients with cardiac Behçet's Syndrome: from the Shanghai Behçet's Syndrome database

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