Impact of double filtration plasmapheresis on adhesion molecules levels in patients with stable coronary heart disease after coronary stenting

Тишко, В. В.; Соколов, А. А.; Bel'skih, A. N.; Ivanov, A. M.; Meshkova, M. E.; Skorinova, Tatyana S.

doi:10.1016/j.atherosclerosissup.2017.05.024

Cited by 10 publications

(9 citation statements)

References 27 publications

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“…We hypothesized that the endothelial damage was greater after PTA with selective stent positioning than after vein graft implantation and continued, even if this observation is difficult to explain, during the postoperative period. Similarly, ICAM-1, which is poorly detected in a normal endothelium but is expressed by a damaged endothelium, triggering the leukocyte adhesion stage and its trans-endothelial migration, [21][22][23] had a significantly higher plasma level in patients undergoing endovascular procedures. Our findings are compatible with the role of these molecules in promoting the beginning and maintenance of the restenosis process.…”

Section: Discussionmentioning

confidence: 99%

Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing

Sapienza

Mingoli

Borrelli

et al. 2019

International Wound Journal

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Prodromal signs of a non-healing wound after revascularisation, which might be strictly linked with impending failure of vascular reconstructions, are associated with an inflammatory response mediated by several circulating adhesion molecules, extracellular endopeptidases, and cytokines. The aim of our study was to investigate the role of selected plasma biomarkers in the prediction of both wound healing and failure of infrapopliteal vein graft or percutaneous trans-luminal angioplasty (PTA) with selective stent positioning of the superficial femoral artery (SFA) in a population affected with critical limb ischaemia. A total of 68 patients who underwent either surgical or endovascular revascularisation of the inferior limb with autologous saphenous vein infrapopliteal bypass or PTA and selective stenting of the SFA were enrolled in our study. Patients were divided into two groups according to treatment: 41 patients were included in Group 1 (open surgery) and 27 in Group 2 (endovascular procedure). Plasma and blood samples were collected on the morning of surgery and every 6 months thereafter for up to 2 years of follow-up or until an occlusion occurred of either the vein bypass graft or the vessel treated endovascularly. Fifteen age-matched healthy male volunteers were considered a reference for biological parameters. Vascular cell adhesion molecule 1 [VCAM-1]/CD106, inter-cellular adhesion molecule-1 [ICAM-1]/CD54), interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α), and metalloproteinases (MMP)-2 and -9 plasma levels were measured with enzyme-linked immunosorbent assay (ELISA) kits. The mean observed time to heal of 54 wounds was 13 ± 4 months, with no statistically significant differences among the groups. The healing failure of the remaining wounds was strictly related to an unsuccessful open (n = 12) or endovascular (n = 8) treatment. The 2-year primary patency rate was 65% (SE = .09) in Group 1 and 52% (SE = .1) in Group 2. When compared with mean concentration values of Group 1, VCAM-1 and ICAM-1 were always significantly higher during follow-up in patients of Group 2 (P < .05). Furthermore, in the same group, IL-6 and tumour necrosis factor alpha (TNF-α) were found to be significantly higher at 6-and 12-month (P < .05) when compared with surgically treated patients. Cox regression analysis showed that

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Section: Discussionmentioning

confidence: 99%

Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing

Sapienza

Mingoli

Borrelli

et al. 2019

International Wound Journal

View full text Add to dashboard Cite

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“…Patients with T2DM have a high risk for vascular restenosis following endovascular interventional therapy (4,25,26). Imbalanced caloric intake is the major cause of T2dM, and previous data have indicated that excessive plasma FFA levels induced by a high fat intake are responsible for this pathological change (27). The up regulation of FFAs is a more sensitive indicator of excessive calorie intake than other blood lipid indices, including AST, ALT, and LdL-c levels.…”

Section: Discussionmentioning

confidence: 99%

Upregulated 14‑3‑3β aggravates restenosis by promoting cell migration following vascular injury in diabetic rats with elevated levels of free fatty acids

et al. 2018

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Mono‑unsaturated free fatty acids (FFAs) can serve as a predictive indicator of vascular restenosis following interventional therapy, particularly in individuals with high‑fat diet‑induced type 2 diabetes. However, the pathogenic mechanism remains to be fully elucidated. In the present study, the levels of tyrosine 3‑monooxygenase/tryptophan 5‑monooxygenase activation protein β (YWHAB; also known as 14‑3‑3β), in vascular smooth muscle cells (VSMCs) treated with different concentrations of oleic acid (OA) were examined by reverse transcription‑quantitative polymerase chain reaction and western blot analyses. The migration of VSMCs was examined using wound‑healing and Transwell migration assays. The protein distribution of B‑cell lymphoma 2 (BCL‑2)‑associated death promoter (BAD) in VSMCs treated with OA was examined by immunofluorescence and western blot analyses. In in vivo experiments, the carotid artery morphology of rats in different groups was assessed at 14 days post‑injury by non-invasive ultrasonographic imaging and confirmed by histological staining. The expression of YWHAB was upregulated by OA in a concentration‑dependent manner in VSMCs. In the in vivo experiments, carotid stenosis was more serious among high‑FFA diabetic rats. However, silencing of YWHAB significantly alleviated carotid neointimal hyperplasia among the diabetic rats with elevated FFA levels. In addition, YWHAB silencing alleviated the migration of OA‑treated VSMCs and increased translocation of the BAD protein from the cytoplasm to the mitochondria. In conclusion, the results showed that FFA‑induced upregulation of YWHAB was involved in neointimal hyperplasia by enhancing the migration of VSMCs following carotid artery injury. The inhibition of YWHAB may serve as a novel potential pharmacological target for preventing vascular restenosis following interventional therapy in diabetic individuals with high FFA levels.

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“…Earlier Heparin-induced Extracorporeal LDL Precipitation (HELP) has been proved to be capable to reduce lipid and the risks of CVD in patients with familial hypercholesterolemia, however, high costs of consumable and treatment prevented its further large-scale clinic usages. Instead, double ltration plasmapheresis (DFPP) has recently replaced HELP in the treatment of familial hypercholesterolemia, hyperlipidemia-leaded severe acute pancreatitis, and coronary artery disease after coronary artery stenosis [15][16][17][18]. DFPP owns the advantages: simplicity of operator, safety for patients, low price (7000 RMB, equal to 1000 US dollars/each session, can be covered by Medicare), short treat time (3-4 hours) and without plasma or albumin replace.…”

Section: Introductionmentioning

confidence: 99%

Plasma Purification is Associated With Reduced Inflammation Factors and Down-regulation of Lipid Metabolic and ER Stress Proteins in Patients With Hyperlipidemia

Zhang

Deng

et al. 2020

Preprint

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Background Hyperlipidemia is a strong risk factor for arteriosclerosis and cardiovascular disease (CVD). Lipid-lowering therapy using drugs often results in many side effects. The aim of our study is to investigate the potential effects of non-drug therapy by double filtration plasmapheresis (DFPP) on lipid metabolic, endoplasmic reticulum (ER) stress and apoptosis related proteins in peripheral blood mononuclear cells (PBMC) before and after lipid clear out in patients with hyperlipidemia. MethodsLipid metabolic [CD36, propotein convertase subtilisin/kexin type 9 (PCSK9) and LDL receptor], ER stress (GRP78, CHOP, ATF4, EIF2a) and apoptosis related (Bcl-2, BAX, and Caspase-3) proteins were assayed by western blot, reactive oxygen species (ROS) measured by flow cytometry (FCM) and serum inflammatory factors were detected by ELISA. Results35 patients with hyperlipidemia were selected into this study. Compared with pre-DFPP, most of lipid metabolic parameters as cholesterol, triglyceride, LDL, lipoprotein a [Lp(a)] and small dense LDL cholesterol (sdLDL) reduced. DFPP process was associated with the down-regulation of lipid metabolic, ER stress and apoptosis proteins, also resulted in the decrease in ROS and serum inflammatory factors release. Conclusion DFPP owns the capacity of lipid-lowering, also can regulate lipid metabolic, ER stress and apoptosis related proteins in PBMC and reduce inflammatory factors in patients with hyperlipidemia (ClinicalTrials.gov number, NCT03491956). Footnote: Xiao Meng Zhang and Hao Deng contribute equally to this paper.

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Impact of double filtration plasmapheresis on adhesion molecules levels in patients with stable coronary heart disease after coronary stenting

Cited by 10 publications

References 27 publications

Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing

Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing

Upregulated 14‑3‑3β aggravates restenosis by promoting cell migration following vascular injury in diabetic rats with elevated levels of free fatty acids

Plasma Purification is Associated With Reduced Inflammation Factors and Down-regulation of Lipid Metabolic and ER Stress Proteins in Patients With Hyperlipidemia

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