Impact of dry eye disease and treatment on quality of life

Friedman, Neil J.

doi:10.1097/icu.0b013e32833a8c15

Cited by 206 publications

(153 citation statements)

References 47 publications

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“…However, it often requires frequent application and turns out only symptomatic relief. 22 Recently, two novel agents-Diquafosol and Rebamipide-with different mechanisms have entered dry eye treatment clinical trials, which bought out promising results. Diquafosol is a P2Y 2 purinergic receptor agonist which can stimulate both fluid secretion from conjunctival epithelial cells and mucin secretion from conjunctival goblet cells directly on the ocular surface independently of lacrimal gland.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study

et al. 2015

Eye

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study

et al. 2015

Eye

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“…The economic burden on the USA may amount to $55 billion USD per year [10,11]. Furthermore, it inflicts a huge impact on the patients' quality of life functional capacity and work productivity [12,13]. Symptoms, the driver of dry eye morbidity, significantly impair physical and mental functioning, and the impact of moderate-to-severe dry eye symptoms is almost equivalent to that of severe migraine [14].…”

Section: Dry Eye As a Clinical Problemmentioning

confidence: 99%

From Volume to Value: Prospects and Pitfalls in Organising Integrated Dry Eye Practice Units

Goh¹,

Korne²,

Tong³

2017

J Clin Exp Ophthalmol

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With the advent of aging populations, chronic multifactorial diseases will dominate and strain existing models of health care. A model of healthcare delivery that emphasizes seamless, integrated, team-based care and remuneration for patient outcomes, have proven advantageous in diseases like diabetes mellitus, compared to systems based on isolated medical services. It is, however, unclear whether major chronic ophthalmic diseases including dry eye are also suitable for this model. Multiple co-morbidities such as depression, anxiety, postmenopausal mood swings, sleep disorders, and chronic neuropathic pain in dry eye greatly and unexpectedly increase its healthcare burden, and also produce high levels of patient and physician frustration. Many patients benefit from counseling, social support, and psychological management, but are frustrated by multiple referrals and inefficiency in care coordination. With the new model, patients may have a seamless transition between care settings, better experience and improved outcomes, and likely attain added value per unit cost.Keywords: Eye diseases; Health policy; Practice guidelines as topic; Primary health care; Quality of health care Rethinking Care for Chronic DiseasesThe trend of medical sub-specialization with the development and proliferation of organ-based or medical technique-based healthcare centers has clearly benefited many generations of people in developed and even developing countries [1]. The advantages of providing highend care are mainly in single, acute problems requiring specialized skills. However, incurable and disabling chronic multi-organ diseases are increasing, due to aging of communities and partly, success of specialized disciplines in management of treatable maladies. We define chronic disease as by WONCA International Classification Committee: a health condition that is long in duration-often with long latency and protracted course, multi-factorial in aetiology, no definite cure, changes gradually over time, heterogeneous in susceptibility" [2], including the lived experience of coping with health disruption and impact on psychological and social function [3].In chronic diseases with multiple comorbidities, health-care disciplines should be integrated and centered on the patient. The "Esther network" [4] and Ed Wagner's chronic disease model [5] are examples of integration across the entire continuum of care, including self and community care, which also cater to the bio psychosocial needs of a person [6]. A study involving 113,452 unique patients evaluated the integration of primary healthcare family practice, internal medicine and geriatric practices, and found superior outcomes in terms of depression screening rates and increased adherence to care, with less emergency visits/admissions [7].The traditional model of healthcare, pivoted around specialized tertiary centers ( Figure 1A), is not optimized for chronic disease care. Traditional healthcare models are largely 'serviced-based' , whereby patients are typically charged for each i...

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“…As alleviation of dry eye symptoms is of primary importance in dry eye treatment, identification of dry eye symptoms can be regarded as important as objective dry eye tests are (Bandeen-Roche et al, 1997;Lemp, 1995;Nichols et al, 2000). More recently, the impact of dry eye on quality of life parameters has been suggested as a more valuable tool for assessing the burden of disease as well as response to treatment (Friedman, 2010). Currently, the majority of clinicians probe into the patient's symptomatology regularly and the clinical tests most routinely used to evaluate severity of dry eye are tear break up time and corneal staining (Smith et al, 2008).…”

Section: Dry Eye Diagnosismentioning

confidence: 99%

“…In the United States alone, approximately 7-10 million Americans require artificial tear preparations, with consumers spending over $100 million/year (Lee et al, 2002). In moderate and severe cases, dry eye can impair the ability of patients to perform activities of daily living, impact work productivity, and influence mood and confidence (Friedman, 2010). Obviously, a high proportion of cataract patients who are candidates for cataract surgery have dry eye; furthermore, there are overwhelming evidences suggesting aggravation or Cataract Surgery 340 initiation of dry eye following cataract surgery (Cohen, 1982;Gharaee et al, 2009;Hardten, 2008;Insler et al, 1985;Jones and Maguire, 1992;Khanal et al, 2008;Ram et al, 2002;Ram et al, 1998;Roberts and Elie, 2007).…”

Section: Introductionmentioning

confidence: 99%

Cataract Surgery and Dry Eye

Daneshvar¹

2013

Cataract Surgery

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Impact of dry eye disease and treatment on quality of life

Cited by 206 publications

References 47 publications

Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study

Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study

From Volume to Value: Prospects and Pitfalls in Organising Integrated Dry Eye Practice Units

Cataract Surgery and Dry Eye

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