Impact of dysphagia on quality of life after treatment of head-and-neck cancer

Nguyen, Nam P.; Frank, Cheryl; Moltz, Candace C.; Vos, Paul; Smith, Harold H.; Karlsson, Ulf; Dutta, Suresh; Midyett, Allan; Barloon, Jessica; Sallah, Sabah

doi:10.1016/j.ijrobp.2004.06.017

Cited by 293 publications

(247 citation statements)

References 34 publications

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“…After CRT (on average, 19 weeks), seven patients (64%) aspirated and six of them had no cough reXex in response to material entering the airway. In the study by Nguyen et al [64] (N = 63), three patients presented trace aspiration and seven severe aspiration at diagnosis (17% in total). Following treatment, 31 patients (49%) aspirated.…”

Section: Aspirationmentioning

confidence: 95%

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review

Molen

Rossum

Burkhead

et al. 2008

Eur Arch Otorhinolaryngol

110

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Organ preservation with radiotherapy and concomitant chemotherapy has become an accepted treatment modality in advanced head and neck cancer. Unfortunately, organ preservation is not synonymous with function preservation. The aim of this review was to systematically assess the eVects of the disease and chemoradiotherapy (CRT) on functions such as swallowing, mouth opening, nutrition, pain and quality of life in patients with head and neck cancer. Another aim was to search for (evidence-based) techniques or strategies known to alleviate or rehabilitate the loss of function(s) associated with CRT. Two databases were searched (time period, January 1997 to August 2007) for the terms head and neck cancer, chemotherapy or cisplatin and radiotherapy, and the functional outcomes swallowing, trismus, nutrition, pain and quality of life or a variation of those words. In total, 15 relevant articles were identiWed that met the inclusion criteria. The majority of the studies that met the criteria focused on the outcomes swallowing, quality of life, and nutrition. Two studies reported on the outcome pain, but no paper reported on the outcome trismus. Only two papers mentioned rehabilitation options, but speciWc information was lacking. Further long-term prospective research is essential, not only to determine the function impairment caused by the tumor and CRT, but also to assess the eVects of known and newly developed rehabilitation measures. Therefore, in September 2006, the Netherlands Cancer Institute started a randomised clinical trial (RCT): Prevention of trismus, swallowing and speech problems in patients treated with chemoradiotherapy for advanced head and neck cancer. This systematic review was carried out to collect the baseline information for the future outcomes of this RCT.

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Section: Aspirationmentioning

confidence: 95%

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review

Molen

Rossum

Burkhead

et al. 2008

Eur Arch Otorhinolaryngol

110

View full text Add to dashboard Cite

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“…As a consequence, in more recent literature there has been increased consideration of the functional outcomes and changes to quality of life (QoL) associated with dysphagia in the HNC population (Llewellyn, Weinman, McGurk, & Humphris, 2008;Lovell, Wong, Loh, Ngo, & Wilson, 2005;Nguyen et al, 2005). Whilst such research has furthered our understanding of the impact of dysphagia following HNC management, the majority of studies to date have applied quantitative methods to measure the extent of functional change (Barringer, Hutcheson, Sturgis, Kies, & Lewin, 2009;Cartmill, Cornwell, Ward, Davidson, & Porceddu, 2011a;Cartmill et al, 2012;Jensen et al, 2007) or change in QoL (Lovell et al, 2005;Maurer et al, 2011;Nguyen et al, 2005). The value of taking a quantitative approach has been to confirm that a problem exists (Llewellyn et al, 2008;Lovell et al, 2005;Murry, Madasu, Martin, & Robbins, 1998;Nguyen et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Whilst such research has furthered our understanding of the impact of dysphagia following HNC management, the majority of studies to date have applied quantitative methods to measure the extent of functional change (Barringer, Hutcheson, Sturgis, Kies, & Lewin, 2009;Cartmill, Cornwell, Ward, Davidson, & Porceddu, 2011a;Cartmill et al, 2012;Jensen et al, 2007) or change in QoL (Lovell et al, 2005;Maurer et al, 2011;Nguyen et al, 2005). The value of taking a quantitative approach has been to confirm that a problem exists (Llewellyn et al, 2008;Lovell et al, 2005;Murry, Madasu, Martin, & Robbins, 1998;Nguyen et al, 2005). However, such studies have provided little understanding of the key factors that influence or impact on the daily life of people with dysphagia.…”

Section: Introductionmentioning

confidence: 99%

The lived experience of dysphagia following non-surgical treatment for head and neck cancer

Nund

Ward

Scarinci

et al. 2013

International Journal of Speech-Language Pathology

100

102

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“…Whilst acute toxicities, including oedema, mucositis, pain and altered/thickened salivary flow, impair the swallowing mechanism in the short-term [1][2][3][4], radiation-induced tissue fibrosis and chronic oxidative stress perpetuate impairment to the deglutition musculature long after treatment has been completed [5][6][7]. These long-term swallowing complications can contribute to significant survivorship burden for HNC patients [8][9][10], resulting in detrimental impacts on psychosocial aspects of and participation in everyday life [11,12] and ultimately reduced quality of life [13,14].…”

Section: Introductionmentioning

confidence: 99%

Physiological Changes to the Swallowing Mechanism Following (Chemo)radiotherapy for Head and Neck Cancer: A Systematic Review

et al. 2013

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Emerging research suggests that preventative swallowing rehabilitation, undertaken pre-or during (chemo)radiotherapy ([C]RT), can significantly improve early swallowing outcomes for head and neck cancer (HNC) patients. However, these treatment protocols are highly variable. Determining specific physiological swallowing parameters which are most likely to be impacted post-(C)RT would assist in refining clear targets for preventative rehabilitation.Therefore, this systematic review (1) examined the frequency and prevalence of physiological swallowing deficits observed post-(C)RT for HNC, and (2) determined the patterns of prevalence of these key physiological deficits over time post-treatment. Online databases were searched for relevant papers published between January 1998 and March 2013. In total, 153 papers were identified and appraised for methodological quality and suitability based on exclusionary criteria. Ultimately, nineteen publications met the study's inclusion criteria.Collation of reported prevalence of physiological swallowing deficits revealed reduced laryngeal excursion, base of tongue (BOT) dysfunction, reduced pharyngeal contraction and impaired epiglottic movement as most frequently reported. BOT dysfunction and impaired epiglottic movement showed a collective prevalence of over 75% in the majority of patient cohorts, whilst reduced laryngeal elevation and pharyngeal contraction had a prevalence of over 50%. Sub-analysis suggested a trend that the prevalence of key deficits is dynamic although persistent over time. These findings can be used by clinicians to inform preventative intervention, and support the use of specific, evidence-based therapy tasks explicitly selected to target the highly prevalent deficits post-(C)RT for HNC.

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Impact of dysphagia on quality of life after treatment of head-and-neck cancer

Cited by 293 publications

References 34 publications

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review

The lived experience of dysphagia following non-surgical treatment for head and neck cancer

Physiological Changes to the Swallowing Mechanism Following (Chemo)radiotherapy for Head and Neck Cancer: A Systematic Review

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