Impact of early- and late-onset preeclampsia on features of placental and newborn vascular health

Herzog, Emilie M.; Eggink, Alex J.; Reijnierse, Anniek; Kerkhof, Martina A.M.; Krijger, Ronald R. de; Roks, Anton J.M.; Reiss, Irwin; Nigg, Alex L.; Eilers, Paul H.C.; Steegers, Eric A.P.; Steegers‐Theunissen, Régine P.M.

doi:10.1016/j.placenta.2016.11.014

Cited by 60 publications

(47 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only the lumen cross-sectional area of the umbilical arteries differed between the IUGR and control group. Our finding of non-significantly decreased arterial vessel wall thickness conforms to the published literature [29, 30]. …”

Section: Discussionsupporting

confidence: 93%

Maternal Hematological Parameters and Placental and Umbilical Cord Histopathology in Intrauterine Growth Restriction

et al. 2019

View full text Add to dashboard Cite

Objective: To investigate the placental and umbilical cord histopathology in intrauterine growth restriction (IUGR) and their relation to second-trimester maternal hematological parameters. Materials and Methods: Patients were selected for the IUGR group based on estimated fetal weight below the 10th percentile. Patients were recruited into the control group randomly. Patients were followed up with ultrasound, and blood samples were taken between the 20th and 24th gestational weeks. After delivery and formalin fixation, weight and volume of the placenta were recorded and histologic samples were processed. Results: Maternal platelet count strongly correlates with placental weight (r = 0.766). On the other hand, neonatal weight correlates with placental volume (r = 0.572) rather than with placental weight (r = 0.469). Umbilical arterial lumen cross-sectional area correlates with birth weight (r = 0.338). Conclusions: Maternal hematological parameters do not seem to affect neonatal outcome. Our main findings are the correlation of maternal platelet count with placental weight, the correlation of placental volume with birth weight being stronger than the correlation of placental weight with birth weight, and the correlation of umbilical artery lumen cross-sectional area with neonatal weight. Mild histopathologic alterations might occur in normal pregnancies; however, sufficient fetal nutrition can be maintained. This compensatory function of the placenta seems to be insufficient when two or more pathologies are present, which is characteristic for IUGR.

show abstract

Section: Discussionsupporting

confidence: 93%

Maternal Hematological Parameters and Placental and Umbilical Cord Histopathology in Intrauterine Growth Restriction

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Patients with preeclampsia have increased maternal morbidity and mortality rates. (2, 3) Treatment of preeclampsia is limited to symptomatic control and/or early termination of pregnancy. Despite decades of research, the pathogenesis underlying preeclampsia remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development

Feng

et al. 2017

ATVB

View full text Add to dashboard Cite

Objective ADAMTS13 is primarily synthesized in liver. The biosynthesis and its physiological role in placenta are not known. Approach and Results We employed real time polymerase chain reaction (PCR), immunohistochemistry, and Western blotting analyses, as well as proteolytic cleavage of FRETS-VWF73 to determine ADAMTS13 expression in placenta and trophoblasts obtained from individuals with normal pregnancy and patients with severe preeclampsia. We also determined the role of ADAMTS13 in extravillous trophoblasts using a 3-(4,5-Dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay, wound scratch assay, transwell migration assay, tube formation assay, and tissue outgrowth assays. We demonstrated that full-length and proteolytically active ADAMTS13 was expressed in normal human placenta, primarily in the trophoblasts and villous core fetal vessel endothelium during pregnancy. Placental expression of ADAMTS13 mRNA, protein, and proteolytic activity was at the highest levels during the first trimester and significantly reduced at the term of gestation. Additionally, significantly reduced levels of placental ADAMTS13 expression was detected under hypoxic conditions and in patients with preeclampsia. In addition, recombinant ADAMTS13 protease stimulated proliferation, migration, invasion, and network formation of trophoblastic cells in culture. Finally, knockdown of ADAMTS13 expression attenuated the ability of tube formation in HTR-8/SVNEO cells and the extravillous trophoblast outgrowth in placental explants. Conclusions Our results demonstrate for the first time the expression of ADAMTS13 mRNA and protein in normal and abnormal placental tissues and its role in promoting angiogenesis and trophoblastic cell development. The findings support the potential role of the ADAMTS13-von Willebrand factor pathway in normal pregnancy and pathogenesis of preeclampsia.

show abstract

“…In a previous retrospective cohort of 302 pregnancies in women with T1DM, there was a significant positive association between placental weight and the risk for light-for-dates infants, which was particularly evident in pregnancies featuring poor glycemic control during the first trimester (especially first-trimester HbA1c levels �8.5%), highlighting the importance of achieving good glycemic control during early pregnancy [45]. Compared with the findings in women without preeclampsia, earlyonset preeclampsia had significant associations with a lower weight, length, and width of the placenta independent of the duration of gestation and birth weight [46]. In pregnant women with DM and HDP, fetal growth might be determined by the balance between the increased blood glucose supply from the mother to their fetus via the heavier placenta according to the hyperglycemia-hyperinsulinemia theory [5] and the decreased blood glucose supply due to placental dysfunction in women with HDP according to the two-stage model for HDP [12].…”

Section: Discussionmentioning

confidence: 80%

Glycemic control and fetal growth of women with diabetes mellitus and subsequent hypertensive disorders of pregnancy

et al. 2020

View full text Add to dashboard Cite

Pregnant women with diabetes mellitus (DM) are at high risk for hypertensive disorder of pregnancy (HDP). Women with poor control DM sometimes have heavy-for-dates infants. However, women with HDP sometimes have light-for-dates infants. We aim to clarify the relationship between glycemic control and fetal growth in women with DM and/or subsequent HDP. Of 7893 women gave singleton birth at or after 22 gestational weeks, we enrolled 154 women with type 1 DM (T1DM) or type 2 DM (T2DM) whose infants did not have fetal abnormalities. Among women with T1DM or T2DM, characteristics of the three groups (with HDP, without HDP, and with chronic hypertension [CH]) were compared. No women with T1DM had CH, but 19 (17.4%) of 109 with T2DM did. HDP incidence was similar between women with T1DM (22.2%) and T2DM without CH (16.7%). Among women with T1DM, the incidences of fetal growth restriction (FGR) with and without HDP were similar. However, among women with T2DM without CH, this incidence was significantly higher among those with HDP (33.3%) than among those without HDP (5.3%), was significantly more common with HbA1c levels at first trimester � 7.2% (33.3%) than with those < 7.2% (5.6%), and significantly more numerous without pre-pregnancy therapies for DM (23.3%) than with them (3.3%). Among women with T2DM and HDP, those with FGR had smaller placenta SDs and higher insulin dosages at delivery than those without light-for-dates. In multivariate analysis, the presence of diabetic nephropathy was a predictor of T1DM and HDP (P = 0.0105), whereas HbA1c levels � 7.2% before pregnancy was a predictor of T2DM and HDP (P = 0.0009). Insulin dosage � 50U/day at delivery (P = 0.0297) and the presence of HDP (P = 0.0116) independently predicted T2DM, HDP, and FGR development. Insufficient pre-pregnancy treatment of DM increased the risk of HDP.

show abstract

Impact of early- and late-onset preeclampsia on features of placental and newborn vascular health

Cited by 60 publications

References 33 publications

Maternal Hematological Parameters and Placental and Umbilical Cord Histopathology in Intrauterine Growth Restriction

Maternal Hematological Parameters and Placental and Umbilical Cord Histopathology in Intrauterine Growth Restriction

Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development

Glycemic control and fetal growth of women with diabetes mellitus and subsequent hypertensive disorders of pregnancy

Contact Info

Product

Resources

About