Impact of early life adversities on human brain functioning: A coordinate-based meta-analysis

Kraaijenvanger, Eline J.; Pollok, Tania M.; Monninger, Maximilian; Kaiser, Anna; Brandeis, Daniel; Banaschewski, Tobias; Holz, Nathalie E.

doi:10.1016/j.neubiorev.2020.03.008

Cited by 54 publications

(33 citation statements)

References 144 publications

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“…However, amygdala hyperactivation has been found to be one of the core features of the pathophysiology of MDD ( Price and Drevets, 2010 ) and the normalized amygdala has been considered as a key component of symptom remission ( Sheline et al, 2001 ; Fu et al, 2004 ). Moreover, increased amygdala reactivity to sad face stimuli has been documented repeatedly both in depressed patients ( Dannlowski et al, 2007 ; Peluso et al, 2009 ; Victor et al, 2010 ) and in individuals who experienced childhood adversity ( Dannlowski et al, 2012 , 2013 ; Hein and Monk, 2017 ; Heany et al, 2018 ; Kraaijenvanger et al, 2020 ). Notably, negative findings also exist in the literature (e.g.…”

Section: Discussionmentioning

confidence: 98%

“…A large body of evidence indicates that the developing brain is particularly vulnerable to stressful childhood experiences. The repeated or sustained hyperactivation of the stress response system during brain development may alter the maturation of core aspects of socio-cognitive functions and often results in disrupted emotion regulation, altered reward processing, and cognitive impairments ( Shonkoff et al, 2009 ; Pechtel and Pizzagalli, 2011 ; Rokita et al, 2018 ; Kraaijenvanger et al, 2020 ). An increasing amount of neuroimaging studies document long-lasting alterations in the activity of limbic circuits which in turn modify the functioning of four key domains: emotion and memory processing, inhibitory control, and reward processing ( McCrory et al, 2017 ; Kraaijenvanger et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

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Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task

Nagy

Kürtös

Németh

et al. 2021

Neurobiology of Stress

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Importance and objectives Childhood adversity is a strong risk factor for the development of various psychopathologies including major depressive disorder (MDD). However, not all depressed patients experience early life trauma. Functional magnetic resonance imaging (fMRI) studies using facial emotion processing tasks have documented altered blood-oxygen-level-dependent (BOLD) responses in specific cortico-limbic networks both in MDD patients and in individuals with a history of childhood maltreatment (CM). Therefore, a history of maltreatment may represent a key modulating factor responsible for the altered processing of socio-affective stimuli. To test this hypothesis, we recruited MDD patients with and without of maltreatment history to study the long-term consequences of childhood trauma and examined the impact of CM on brain activity using a facial emotion recognition fMRI task. Methods MDD patients with childhood maltreatment (MDD + CM, n = 21), MDD patients without maltreatment (MDD, n = 19), and healthy controls ( n = 21) matched for age, sex and intelligence quotient underwent fMRI while performing a block design facial emotion matching task with images portraying negative emotions (fear, anger and sadness). The history of maltreatment was assessed with the 28-item Childhood Trauma Questionnaire. Results Both MDD and MDD + CM patients displayed impaired accuracy to recognize sad faces. Analysis of brain activity revealed that MDD + CM patients had significantly reduced negative BOLD signals in their right accumbens, subcallosal cortex, and anterior paracingulate gyrus compared to controls. Furthermore, MDD + CM patients had a significantly increased negative BOLD response in their right precentral and postcentral gyri compared to controls. We found little difference between MDD and MDD + CM patients, except that MDD + CM patients had reduced negative BOLD response in their anterior paracingulate gyrus relative to the MDD group. Conclusions Our present data provide evidence that depressed patients with a history of maltreatment are impaired in facial emotion recognition and that they display altered functioning of key reward-related fronto-striatal circuits during a facial emotion matching task.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task

Nagy

Kürtös

Németh

et al. 2021

Neurobiology of Stress

View full text Add to dashboard Cite

show abstract

“…In terms of functional alterations, the most consistent observation is the increased responsivity of the amygdala in individuals with a history of ACE. Amygdala hyperactivity in response to expressive faces, especially threatening faces, has consistently been found in both children and adults with a history of ACE (157,158). This finding is independent from psychiatric diagnosis, indicating that this hyperactivity may be inherent to the experience of adversity in itself (151,152).…”

Section: The Impact Of Adverse Childhood Events On Facial Expression mentioning

confidence: 91%

Facial Expression Processing Across the Autism–Psychosis Spectra: A Review of Neural Findings and Associations With Adverse Childhood Events

et al. 2020

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“…Critically, the above mentioned neurobiobehavioral markers have all been related to how well individuals adapt to adverse events. For instance, the amygdala has proven as key convergence site of social adversity (25) and is critically involved in stress adaptation (25–28). In addition, neuroticism is linked to elevated levels stress reactivity, heightened risk of mood disorders, and overestimation of potential health threats (29–31).…”

Section: Introductionmentioning

confidence: 99%

Real-time individual benefit from social interactions before and during the lockdown: The crucial role of personality, neurobiology and genes

Monninger

et al. 2021

Preprint

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Background: Social integration is a major resilience factor for staying healthy. However, the COVID-19-pandemic led to unprecedented restrictions in social life. The consequences of these social lockdowns on momentary well-being are yet not fully understood. Method: We investigated the individual affective benefit from social interactions in a longitudinal birth cohort study. We used two real-time, real-life ecological momentary assessments once before and once during the initial lockdown of the pandemic (N~6800 total observations) to determine the protective role of social interactions on well-being. Moreover, we used a multimethod approach combining the ecological assessment data with individual risk and resilience factors to analyze the moderating mechanisms of personality, neurobiology and genes. Results: Social contacts were linked to higher positive affect both during normal times and during the COVID-19 pandemic, highlighting the beneficial role of social embedding. Moreover, this relationship was moderated by amygdala volume, neuroticism and polygenic risk for schizophrenia. In detail, participants with a larger left amygdala volume and higher trait neuroticism exhibited an affective benefit from more social interactions prior to the pandemic. This pattern changed during the pandemic with participants with smaller amygdala volumes and lower neurotic traits showing a social affective gain during the pandemic. Moreover, participants with low genetic risk for schizophrenia showed an affective benefit from social interactions irrespective of the time point. Conclusion: Our results highlight the protective role of social integration on momentary well-being. Thereby, we offer new insights into how this relationship is differently affected by a person's neurobiology, personality, and genes under adverse circumstances.

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Impact of early life adversities on human brain functioning: A coordinate-based meta-analysis

Cited by 54 publications

References 144 publications

Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task

Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task

Facial Expression Processing Across the Autism–Psychosis Spectra: A Review of Neural Findings and Associations With Adverse Childhood Events

Real-time individual benefit from social interactions before and during the lockdown: The crucial role of personality, neurobiology and genes

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