Impact of early supplementation with low-dose aspirin on functional first trimester parameters in low-risk pregnancies

Zvâncă, Mona Elena; Boț, Mihaela; Radu, Dan; Radu, Nicoleta; Petca, Aida

doi:10.1080/14767058.2017.1387532

Cited by 13 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…UTIs are caused by different type of bacteria which invades the local environment, then multiply, thus causing the symptomatology. Gender prevalence of UTIs is well known higher in women due to particularly anatomic characteristics of the urinary tract such as shorter urethra, the proximity of the anus and sexual activity [5,48]. Some studies reveal that 1 of 3 women receive specific treatment for UTIs before 24 years and about 40% to 50% develop one UTI during lifetime which leads to high economic costs [12].…”

Section: Resultsmentioning

confidence: 99%

Antibiotic Resistance Profile of Common Uropathogens Implicated in Urinary Tract Infections in Romania

Petca¹

2019

FARMACIA

View full text Add to dashboard Cite

Urinary tract infections (UTIs), the second most common type, are a healthcare problem encountered in medical practice, a major cause of morbidity with a high socio-economic impact. The aim of this retrospective study was to identify the most common uropathogens, their susceptibility and resistance to conventional therapies. We analysed the urine samples from 3896 patients and we enrolled 916 cases. Bacterial isolation and antibiotic susceptibility were made using standard methods. From the Gram-negative, E. coli was the most common identified bacteria (42.9%) followed by Klebsiella (21.17%) and Pseudomonas aeruginosa (4.58%). Enterococcus was the most frequent Gram-positive bacteria (18.66%). E. coli strains showed to have an increased resistance to levofloxacin as same as Klebsiella and Enterococcus. The continuous dynamic of uropathogens in different areas and the increasing resistance to conventional antibiotic therapies is a major contemporary health problem. RezumatInfecțiile de tract urinar (ITU), a doua cauză frecventă de infecții, sunt o problemă des întâlnită în practica medicală, o cauză majoră de morbiditate, cu impact socio-economic puternic. Scopul acestui studiu restrospectiv este de a identifica cei mai frecvenți uropatogeni și de a determina rezistența acestora la tratamentele antibiotice clasice. Au fost analizate 3896 de pr obe dintre care au fost întregistrate 916 cazuri. Izolarea bacteriilor și sensibilitatea la antibiotic a fost realizată prin metode standard. Dintre bacteriile Gram-negative, E. coli a fost cea mai frecvent identificată bacterie (42,9%), urmată de Klebsiella (21,17%) și Pseudomonas aeruginosa (4,58%). Cea mai frecvent izolată bacterie Gram-pozitivă a fost enterococcul (18,66%). Atât E. coli cât și Klebsiella și enterococcul au prezentat rezistență crescută la levofloxacin. Dinamica permanentă a uropatogenilor în diferite regiuni teritoriale și rezistența în creștere la tratamentele antibiotice este o problemă de sănătate majoră a societății actuale pentru care sunt necesare raportări și actualizări permanente.

show abstract

Section: Resultsmentioning

confidence: 99%

Antibiotic Resistance Profile of Common Uropathogens Implicated in Urinary Tract Infections in Romania

Petca¹

2019

FARMACIA

View full text Add to dashboard Cite

show abstract

“…Aspirin has a good safety profile, with no increase in haemorrhagic complications [ 35 ]. It has been proven beneficial for high-risk women with a reduction of up to 80% (with good compliance) of pre-eclampsia development and has also been associated with improving functional placentation parameters even in low-risk pregnant patients when started in early pregnancy [ 36 , 37 ]. As for financial reasons, universal aspirin treatment was associated with the lowest costs compared to screening using biochemical and ultrasound markers, screening using patients’ characteristics and history, or not giving aspirin at all [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of CA-125 First-Trimester Values as a Potential Screening Marker for Pre-Eclampsia

2023

View full text Add to dashboard Cite

Background: Pre-eclampsia is a major public health issue. Current screening methods are based on maternal characteristics and medical history, but complex predictive models combining different clinical and biochemical markers have been proposed. However, although their accuracy is high, the implementation of these models in clinical practice is not always feasible, especially in low- and middle-resource settings. CA-125 is a tumoral marker, accessible and cheap, with proven potential as a severity marker in the third trimester of pregnancy in pre-eclamptic women. Assessment of its use as a first-trimester marker is necessary. Methods: This observational study involved fifty pregnant women between 11 and 14 weeks of pregnancy. Clinical and biochemical markers (PAPP-A), known for their value in pre-eclampsia screening, were recorded for every patient as well as first-trimester value of CA-125 and third-trimester data regarding blood pressure and pregnancy outcome. Results: No statistical correlation between CA-125 and first-trimester markers was observed except with PAPP-A, with which it exhibited a positive correlation. Additionally, no correlation was made between it and third-trimester blood pressure or pregnancy outcomes. Conclusions: CA-125 first-trimester values do not represent a valuable marker for pre-eclampsia screening. Further research on identifying an accessible and cheap marker to improve pre-eclampsia screening in low- and middle-income settings is needed.

show abstract

“…Low-dose aspirin is used to inhibit platelet aggregation and prevent pre-eclampsia. 17 Due to the similarity between the mechanisms of spontaneous PTL and pre-eclampsia, it has been suggested that lowdose aspirin may also be used to prevent spontaneous PTL. Some studies have performed secondary analyses of data on the effect of low-dose aspirin on the prevention of preeclampsia to evaluate the effect of low-dose aspirin on the prevention of PTL.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Low-dose Aspirin on the Prevention of Preterm Delivery in Women with a History of Spontaneous Preterm Delivery

Mirzamoradi,

Dehghani,

Azadi

et al. 2023

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

Objective Currently, uteroplacental vascular disorders are considered one of the main mechanisms of spontaneous preterm delivery (PTD). Low-dose aspirin is used to prevent pre-eclampsia, which has a similar mechanism; hence, the present study aimed to investigate the effect of low-dose aspirin on the prevention of PTD in women with a history of spontaneous PTD. Methods The present pilot randomized clinical trial was conducted on 54 pregnant women in the aspirin group (taking 80 mg daily until the 36th week and classic treatment) and 53 patients in the control group (only receiving classic treatment). Results Forty-three patients (40%) presented before 37 weeks due to symptoms of PTL. Preterm delivery (< 37 weeks) occurred in 28 patients (26%), and there was no significant difference between the aspirin and control groups (10 patients [19%] and 18 patients [34%], respectively; p = 0.069). The time of preterm delivery was early (< 34 weeks) in 6 patients (21%), and its cause was spontaneous labor in 23 patients (82%) which was not significantly different between the two groups (p > 0.05). Out of 40 patients with spontaneous labor, 25 patients (63%) had a PTD, which was significantly lower in the aspirin group than in the control group (9 patients [45%] versus 16 patients [80%], respectively; p = 0.022). Conclusion The findings of the present study demonstrated that despite the reduction in the incidence of PTD using low-dose aspirin, the reduction rate was not statistically significant. On the other hand, in patients with spontaneous labor prone to PTD, aspirin was effective in reducing the incidence of PTD.

show abstract

Impact of early supplementation with low-dose aspirin on functional first trimester parameters in low-risk pregnancies

Abstract: Even though the results are not always statistically significant, they demonstrate that placentation parameters improve with higher doses of aspirin started before 11 weeks.

Cited by 13 publications

References 11 publications

Antibiotic Resistance Profile of Common Uropathogens Implicated in Urinary Tract Infections in Romania

Antibiotic Resistance Profile of Common Uropathogens Implicated in Urinary Tract Infections in Romania

Assessment of CA-125 First-Trimester Values as a Potential Screening Marker for Pre-Eclampsia

Evaluation of the Effect of Low-dose Aspirin on the Prevention of Preterm Delivery in Women with a History of Spontaneous Preterm Delivery

Contact Info

Product

Resources

About