Problematic polypharmacy is an ongoing issue for older adults throughout Canada, and specifically among nursing home residents (Maher, Hanion, & Hajjar, 2013). Despite interventions that are currently in place in British Columbia (BC) to reduce the causes and outcomes of this issue, problematic polypharmacy continues to pose a risk for residents among BC nursing homes. This integrative review asks how nurse practitioners (NPs) can best promote a reduction in the causes and outcomes of problematic polypharmacy among residents in BC nursing homes.The background information of this project outlines the concept of problematic polypharmacy and the prevalence of contributing factors and outcomes. Nursing home demographics are also highlighted to demonstrate the risk this population faces to the causes and outcomes of problematic polypharmacy, and the subsequent effect this issue has on the health care system. Furthermore, the background provides an overview of the concept role overlap which exists between health care professionals in order to demonstrate how multiple health care professionals may share roles or parts of roles in reducing the causes and outcomes of problematic polypharmacy. Barriers faced by staff are also examined.Through a comprehensive review of the literature and critical appraisal, nine articles are found to address the research question. Key interventions that specifically demonstrate effectiveness in reducing causes and outcomes of problematic polypharmacy in the context of nursing homes emerged. These interventions are put forth as recommendations for NP practice and include: medication reviews while screening for inappropriate medications by using the Beers Criteria, computerized clinical decision support systems (CCDSS), and the Cockcroft Gault Score; assessing functional status for changes to assure instances of problematic 3 polypharmacy are not missed by using the Minimum Data Set -Activity of Daily Living (MDS-ADL) scale; education targeted for all staff members to detect, prevent, and manage problematic polypharmacy; multidisciplinary team meetings to facilitate a collaborative approach in reducing problematic polypharmacy and case conferences to provide resident-centered care.An important finding is that most interventions require participation from two or more health professionals, highlighting the concept of role overlap and the necessity of a multidisciplinary approach. In light of NP practice, this provides insight surrounding how NPs can influence and encourage other staff members to sustain their roles and overcome barriers for an ultimate reduction in the causes and outcomes of problematic polypharmacy with implications for practice, policy, education, and research.