Impact of effluent of Pulp &amp; Paper industry on the flora of river basin at Jaykaypur, Odisha, India and its ecological implications.

Tripathy, A.P.; Dixit, Prasanna Kumar; Panigrahi, A. K.

doi:10.1016/j.envres.2021.111769

Cited by 17 publications

(7 citation statements)

References 15 publications

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“…Although the content of Cd in water is strictly monitored all over the world, its concentrations still exceed the standard in many areas. The latest surveys revealed that the concentrations of Cd 2+ range from 0.1 to 0.3 μg/L in various water systems and can even reach 300 μg/L in polluted rivers [ 7 , 8 , 9 , 10 ]. Specifically, the concentration of Cd in groundwater around waste disposal sites in the United States is as high as 6000 μg/L and leachates from municipal solid waste landfills in the European Union can reach up to 2700 μg/L [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging

Liu

Tian

et al. 2022

IJMS

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Cadmium (Cd) is a toxic heavy metal and worldwide environmental pollutant which seriously threatens human health and ecosystems. It is easy to be adsorbed and deposited in organisms, exerting adverse effects on various organs including the brain. In a very recent study, making full use of a zebrafish model in both high-throughput behavioral tracking and live neuroimaging, we explored the potential developmental neurotoxicity of Cd2+ at environmentally relevant levels and identified multiple connections between Cd2+ exposure and neurodevelopmental disorders as well as microglia-mediated neuroinflammation, whereas the underlying neurotoxic mechanisms remained unclear. The canonical Wnt/β-catenin signaling pathway plays crucial roles in many biological processes including neurodevelopment, cell survival, and cell cycle regulation, as well as microglial activation, thereby potentially presenting one of the key targets of Cd2+ neurotoxicity. Therefore, in this follow-up study, we investigated the implication of the Wnt/β-catenin signaling pathway in Cd2+-induced developmental disorders and neuroinflammation and revealed that environmental Cd2+ exposure significantly affected the expression of key factors in the zebrafish Wnt/β-catenin signaling pathway. In addition, pharmacological intervention of this pathway via TWS119, which can increase the protein level of β-catenin and act as a classical activator of the Wnt signaling pathway, could significantly repress the Cd2+-induced cell cycle arrest and apoptosis, thereby attenuating the inhibitory effects of Cd2+ on the early development, behavior, and activity, as well as neurodevelopment of zebrafish larvae to a certain degree. Furthermore, activation and proliferation of microglia, as well as the altered expression profiles of genes associated with neuroimmune homeostasis triggered by Cd2+ exposure could also be significantly alleviated by the activation of the Wnt/β-catenin signaling pathway. Thus, this study provided novel insights into the cellular and molecular mechanisms of Cd2+ toxicity on the vertebrate central nervous system (CNS), which might be helpful in developing pharmacotherapies to mitigate the neurological disorders resulting from exposure to Cd2+ and many other environmental heavy metals.

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Section: Introductionmentioning

confidence: 99%

Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging

Liu

Tian

et al. 2022

IJMS

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“…Our studies in this environment on mothers and newborns revealed a disproportionate number of babies with low birth weight, decreased length and reduced head circumference (Ikeh-Tawari et al, 2013). Damaging effects of environmental chemicals on reproductive capacity of flora is also well known (Tripathy et al, 2022).…”

Section: The Contribution Of Environmental Pollution To Reproductive ...mentioning

confidence: 77%

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

et al. 2022

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There is current great international concern about the contribution of environmental pollution to the global burden of disease particularly in the developing, low- and medium-income countries. Industrial activities, urbanization, developmental projects as well as various increased anthropogenic activities involving the improper generation, management and disposal of pollutants have rendered today’s environment highly polluted with various pollutants. These pollutants include toxic metals (lead, cadmium, mercury, arsenic), polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pesticides and diesel exhaust particles most of which appear to be ubiquitous as well as have long-term environmental persistence with a wide range of toxicities such as oxidative stress among others. Oxidative stress, which may arise from increased production of damaging free radicals emanating from increased pollutant burden and depressed bioavailability of antioxidant defenses causes altered biochemical and physiological mechanisms and has been implicated in all known human pathologies most of which are chronic. Oxidative stress also affects both flora and fauna and plants are very important components of the terrestrial environment and significant contributors of nutrients for both man and animals. It is also remarkable that the aquatic environment in which sea animals and creatures are resident is also highly polluted, leading to aquatic stress that may affect the survival of the aquatic animals, sharing in the oxidative stress. These altered terrestrial and aquatic environments have an overarching effect on human health. Antioxidants neutralize the damaging free radicals thus, they play important protective roles in the onset, progression and severity of the unmitigated generation of pollutants that ultimately manifest as oxidative stress. Consequently, human health as well as that of aquatic and terrestrial organisms may be protected from environmental pollution by mitigating oxidative stress and employing the principles of nutritional medicine, essentially based on antioxidants derived mainly from plants, which serve as the panacea of the vicious state of environmental pollutants consequently, the health of the population. Understanding the total picture of oxidative stress and integrating the terrestrial and aquatic effects of environmental pollutants are central to sustainable health of the population and appear to require multi-sectoral collaborations from diverse disciplinary perspectives; basically the environmental, agricultural and health sectors.

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“…The accumulation of metals in plants is influenced by various factors, including metal species, plant species, the genetic makeup of the plant species, the bioavailability of metals, and the prevailing climatic conditions in the cultivation area, microbial diversity in the soil (Čásová et al, 2009;Bauddh et al, 2016;Saha et al, 2021;Ankit et al, 2022). Application of industrial effluent for irrigation of crops is known to affect several physiological systems in plants (Chowdhry et al, 2020;Tripathy et al, 2022). However, few responses are indicative of the fact that if effluents are diluted sufficiently, it can bring some benefit to crop physiology (Kumar et al, 2015).…”

Section: Translocation Factormentioning

confidence: 99%

Growth, Metal Accumulation Potential and Antioxidant Enzyme Responses of Ricinus communis L. Genotypes Exposed to Cement Industry Effluent

Bauddh,

Ankit,

Kumar

et al. 2023

IJPE

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The current study was carried out to delineate the effect of cement industry effluent on the two screened varieties of R. communis(Castor) viz. MSC-55 and Western-6. A number of analyses such as growth parameters, photosynthetic pigment, metal accumulationand antioxidant enzyme were performed on both the varieties. With respect to T0 (100% tap water), an increase of 86.84, 90.97 and80.15% was noticed in the fresh weight (FW) of roots of MSC-55 variety at 30, 60 and 90 DAS, respectively, when irrigated with T2 (50%effluent+50% tap water). The results obtained significantly differed between T0 and T2 and T0 and T4 (at p ≤ 0.05). MSC-55 variety wasobserved to contain an increased amount of total chlorophyll and carotenoids up to T2 concentration which declined at higher effluentconcentration i.e., T4 (100% effluent). Increased concentration of Cement Industry Effluent (CIE) enhanced the generation of someantioxidant compounds like Guaiacol peroxidase (GPX) and Ascorbate peroxidase (APX) in both the varieties up to certain treatmentconcentrations viz. MSC-55 and Western-6. As the effluent concentration increased in both the varieties, the amount of malondialdehyde(MDA) in the leaves and roots also rose. With increasing effluent concentrations, Catalase (CAT) and Superoxide dismutase (SOD)also increased. MSC-55 variety of R. communis was observed to have a strong antioxidant defence system against CIE and could berecommended for cultivation during metal-contaminated industrial effluent condition.

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Impact of effluent of Pulp & Paper industry on the flora of river basin at Jaykaypur, Odisha, India and its ecological implications.

Cited by 17 publications

References 15 publications

Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging

Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

Growth, Metal Accumulation Potential and Antioxidant Enzyme Responses of Ricinus communis L. Genotypes Exposed to Cement Industry Effluent

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